HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	25527291, 27425610, 30097011, 36563856
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1058 Hs			1 147
+	Hs
		607026 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		607050 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		607039 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		607136 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		607129 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		607028 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		607023 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2A_HUMAN (2-144): 4.45e-71: 211: 41.26
+	Hs
		607054 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (2-144): 2.02e-70: 210: 39.86
+	Hs
		607042 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Dm
		715098 Q8T0L3_DROME (36-1057): 0: 1108: 59.75		UBE2N_DROME (4-147): 2.18e-71: 212: 49.31
+	Sp
		293848 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (1-147): 1.16e-80: 236: 83.67
+	Sc
		549788 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (3-147): 9.94e-80: 233: 80.69
+	Hs
		48104 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		48107 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		48106 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Sp
		251976 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC1_SCHPO (4-146): 1.02e-45: 149: 47.22
+	Hs
		782203 UBA7_HUMAN (41-1057): 0: 1006: 46.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Sp
		293851 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC14_SCHPO (6-146): 7.65e-43: 140: 45.78
+	Sc
		600919 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC1_YEAST (4-146): 8.4e-43: 142: 46.90
+	Hs
		1282360 SAE2_HUMAN (60-451): 2.55e-88: 299: 17.08		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34