HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 1088
+	Hs
		665340 EPHA2_HUMAN (4-789): 0: 573: 19.58		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		607895 FGFR4_HUMAN (13-802): 0: 750: 100.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		507876 FGFR1_HUMAN (3-794): 0: 706: 54.76		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		507838 FGFR1_HUMAN (3-794): 0: 706: 54.76		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		607926 FGFR4_HUMAN (13-802): 0: 750: 100.00		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		607975 FGFR4_HUMAN (13-802): 0: 750: 100.00		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		601482 FGFR2_HUMAN (4-797): 0: 737: 56.44		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		601517 FGFR2_HUMAN (4-797): 0: 737: 56.44		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		665151 EPHA2_HUMAN (4-789): 0: 573: 19.58		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		609219 FGFR3_HUMAN (5-799): 0: 712: 61.07		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		507919 FGFR1_HUMAN (3-794): 0: 706: 54.76		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		508016 FGFR1_HUMAN (3-794): 0: 706: 54.76		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		568557 EPHA2_HUMAN (4-789): 0: 573: 19.58		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Rn
		979772 FGFR1_RAT (3-794): 0: 698: 54.27		KS6A1_RAT (519-977): 6.83e-81: 281: 19.87
+	Hs
		507982 FGFR1_HUMAN (3-794): 0: 706: 54.76		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		254442 FGFR1_HUMAN (3-794): 0: 706: 54.76		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90
+	Hs
		384267 NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53		KAPCB_HUMAN (638-1022): 1.92e-133: 410: 31.36
+	Hs
		665595 EPHB2_HUMAN (4-779): 0: 557: 17.27		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		384525 NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		254431 NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90