HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: LASP1 (Q14847)
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Gene: LASP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 261
+	Hs
		609599 FGFR3_HUMAN (10-806): 0: 819: 100.00		DBNL_HUMAN (59-261): 2.02e-25: 105: 23.65
+	Hs
		609616 FGFR3_HUMAN (10-806): 0: 819: 100.00		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		1072630 EPHA7_HUMAN (1-782): 0: 626: 21.22		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		665684 EPHB2_HUMAN (1-788): 0: 624: 19.15		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		872731 EPHA4_HUMAN (1-781): 0: 622: 20.78		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		562635 EPHA4_HUMAN (1-781): 0: 622: 20.78		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Hs
		1081652 NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Mm
		452188 CSF1R_MOUSE (5-764): 1.87e-167: 511: 27.49		PLCG2_MOUSE (17-261): 7.01e-22: 96.9: 13.88
+	Hs
		1081582 NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59		SH3G1_HUMAN (48-261): 6.99e-24: 100: 18.81
+	Hs
		499228 KIT_HUMAN (19-794): 1.17e-165: 506: 24.62		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Hs
		562650 NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Rn
		499163 NTRK2_RAT (135-756): 1.07e-160: 489: 24.74		PLCG1_RAT (14-261): 1.2e-21: 96.1: 16.94
+	Hs
		384821 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		ARHG7_HUMAN (43-261): 1.37e-25: 107: 14.16
+	Hs
		385685 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		DBNL_HUMAN (59-261): 2.02e-25: 105: 23.65
+	Hs
		385734 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		384833 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		385463 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		SRBS1_HUMAN (149-259): 7.54e-13: 69.9: 31.30
+	Hs
		434313 RET_HUMAN (453-801): 9.71e-98: 330: 48.63		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		434276 RET_HUMAN (453-801): 9.71e-98: 330: 48.63		SH3G2_HUMAN (47-261): 5.88e-23: 98: 18.14
+	Mm
		913887 PTK7_MOUSE (160-362): 3.3e-16: 85.6: 17.96		ABI2_MOUSE (36-261): 1.51e-21: 94.9: 18.14