Protein: TMEDA
Endoplasmic reticulum vesicle protein 25

Gene: TMEDA, ERV25
Organism: Saccharomyces cerevisiae S288C
Interactions: 125
UniProt ID: P54837

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000324 - fungal-type vacuole
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

932633

ERP1
Protein ERP1

7

17

Small-scale

0.965

High

745381

EMP24
Endosomal protein P24B

6

18

Small-scale

0.953

High

805335

ERP5
Protein ERP5

5

19

Small-scale

0.924

High

813605

ERP2
Protein ERP2

5

18

Small-scale

0.922

High

918137

ERP6
Protein ERP6

4

19

Small-scale

0.888

High

932643

ERP4
Protein ERP4

3

19

Small-scale

0.850

High

932642

ERP3
Protein ERP3

2

19

Small-scale

0.789

High

932617

TMEDA
Endoplasmic reticulum vesicle protein 25

1

18

High-throughput

0.698

High

582504

SEC23
Protein transport protein SEC23

2

17

Small-scale

0.624

High

825236

SEC24
Protein transport protein SEC24

2

17

Small-scale

0.624

High

932629

SEC13
Protein transport protein SEC13

2

4

Small-scale

0.624

High

748499

SC61A
Protein transport protein SEC61

2

3

High-throughput

0.613

High

780361

MCD4
GPI ethanolamine phosphate transferase 1

2

1

High-throughput

0.613

High

802009

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

2

1

High-throughput

0.613

High

645116

EPT1
Choline/ethanolaminephosphotransferase 1

2

7

High-throughput

0.608

High

836079

COPB2
Coatomer subunit beta'

2

13

Small-scale

0.595

High

721699

GPI10
GPI mannosyltransferase 3

2

1

High-throughput

0.588

High

795487

ATG8
Autophagy-related protein 8

2

3

High-throughput

0.584

High

932639

ATG9
Autophagy-related protein 9

2

2

High-throughput

0.584

High

932630

ERV41
ER-derived vesicles protein ERV41

2

10

High-throughput

0.576

High

922102

COPA
Coatomer subunit alpha

2

13

Small-scale

0.571

High

932618

SED5
Integral membrane protein SED5

2

3

Small-scale

0.571

High

808387

SEC31
Protein transport protein SEC31

1

4

Small-scale

0.561

High

439536

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

2

High-throughput

0.541

High

528624

CP51
Lanosterol 14-alpha demethylase CYP51

1

2

High-throughput

0.541

High

536154

ARF1
ADP-ribosylation factor 1

1

11

High-throughput

0.541

High

609285

CPT1
Cholinephosphotransferase 1

1

7

High-throughput

0.541

High

636340

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.541

High

735354

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

6

High-throughput

0.541

High

754650

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

2

High-throughput

0.541

High

793251

BAP2
Leu/Val/Ile amino-acid permease

1

9

High-throughput

0.541

High

797027

PHO88
SRP-independent targeting protein 3

1

2

High-throughput

0.541

High

798662

SSH1
Sec sixty-one protein homolog

1

3

High-throughput

0.541

High

808692

SUR2
Sphingolipid C4-hydroxylase SUR2

1

6

High-throughput

0.541

High

823164

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

3

High-throughput

0.541

High

826143

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.541

High

827094

GST1
Glutathione S-transferase 1

1

1

High-throughput

0.541

High

849578

COS4
Protein COS4

1

2

High-throughput

0.541

High

849653

EMP47
Protein EMP47

1

1

High-throughput

0.541

High

916771

ERG25
C-4 methylsterol oxidase ERG25

1

6

High-throughput

0.541

High

918143

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

4

High-throughput

0.541

High

919791

ERV29
ER-derived vesicles protein ERV29

1

5

High-throughput

0.541

High

932187

ERG5
C-22 sterol desaturase ERG5

1

2

High-throughput

0.541

High

932621

SHR3
Secretory component protein SHR3

1

1

High-throughput

0.541

High

932622

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

1

High-throughput

0.541

High

932625

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

2

High-throughput

0.541

High

932626

GOT1
Protein transport protein GOT1

1

1

High-throughput

0.541

High

932627

PKR1
V-type ATPase assembly factor PKR1

1

1

High-throughput

0.541

High

932634

ORM2
Protein ORM2

1

1

High-throughput

0.541

High

932638

UIP4
ULP1-interacting protein 4

1

1

High-throughput

0.541

High

932641

RBD2
Rhomboid-type serine protease 2

1

2

High-throughput

0.541

High

932646

SEY1
Protein SEY1

1

1

High-throughput

0.541

High

790340

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.518

High

835929

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.518

High

932623

YDC1
Alkaline ceramidase YDC1

1

0

High-throughput

0.518

High

524827

HSP71
Heat shock protein SSA1

2

8

High-throughput

0.504

High

545887

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.504

High

865374

GEA1
ARF guanine-nucleotide exchange factor 1

1

4

Small-scale

0.501

High

794155

YB91
Probable metabolite transport protein YBR241C

1

5

High-throughput

0.494

High

800912

NCB5R
NADH-cytochrome b5 reductase 1

1

5

High-throughput

0.494

High

932636

VHS3
Phosphopantothenoylcysteine decarboxylase subunit VHS3

1

1

High-throughput

0.494

High

583762

SEC11
Signal peptidase complex catalytic subunit SEC11

1

0

High-throughput

0.493

High

932631

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.493

High

486506

TBA3
Tubulin alpha-3 chain

1

2

High-throughput

0.489

High

921091

PRS10
26S proteasome subunit RPT4

1

4

High-throughput

0.489

High

932619

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.489

High

577192

SEC63
Protein translocation protein SEC63

1

3

Small-scale

0.481

High

564758

ATC1
Calcium-transporting ATPase 1

1

5

High-throughput

0.479

High

610186

PDI
Protein disulfide-isomerase

1

5

High-throughput

0.479

High

613871

ERD2
ER lumen protein-retaining receptor

1

3

High-throughput

0.479

High

633565

SAR1
Small COPII coat GTPase SAR1

1

16

Small-scale

0.479

High

645267

GAS1
1,3-beta-glucanosyltransferase GAS1

1

2

Small-scale

0.479

High

646260

SEC22
Protein transport protein SEC22

1

5

High-throughput

0.479

High

646682

VPS15
Serine/threonine-protein kinase VPS15

1

2

High-throughput

0.479

High

649844

VPS34
Phosphatidylinositol 3-kinase VPS34

1

2

High-throughput

0.479

High

676866

RER1
Protein RER1

1

4

High-throughput

0.479

High

726110

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

5

Small-scale

0.479

High

735856

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

3

Small-scale

0.479

High

754411

SEC66
Translocation protein SEC66

1

1

High-throughput

0.479

High

754713

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

5

Small-scale

0.479

High

801701

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

2

Small-scale

0.479

High

813918

ERV46
ER-derived vesicles protein ERV46

1

10

High-throughput

0.479

High

818184

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

9

Small-scale

0.479

High

863820

ATG27
Autophagy-related protein 27

1

2

High-throughput

0.479

High

916561

YIP1
Protein transport protein YIP1

1

6

High-throughput

0.479

High

923040

ZRG17
Protein ZRG17

1

1

High-throughput

0.479

High

923817

YIF1
Protein transport protein YIF1

1

4

High-throughput

0.479

High

932624

BECN1
Vacuolar protein sorting-associated protein 30

1

2

High-throughput

0.479

High

382273

H4
Histone H4

1

1

High-throughput

0.470

High

932628

HMO1
High mobility group protein 1

1

2

High-throughput

0.470

High

932640

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.470

High

642446

MCK1
Protein kinase MCK1

1

3

High-throughput

0.457

High

932620

UBC7
Ubiquitin-conjugating enzyme E2 7

1

4

High-throughput

0.457

High

932632

DFG5
Mannan endo-1,6-alpha-mannosidase DFG5

1

1

High-throughput

0.457

High

794053

KTR3
Probable mannosyltransferase KTR3

1

2

Small-scale

0.445

High

803644

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.445

High

671005

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

707887

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

795143

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

932206

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.437

High

932635

ATG23
Autophagy-related protein 23

1

2

High-throughput

0.437

High

592428

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

792718

MNN2
Alpha-1,2-mannosyltransferase MNN2

1

0

Small-scale

0.426

High

836016

COPB
Coatomer subunit beta

1

7

Small-scale

0.408

High

850741

COPD
Coatomer subunit delta

1

5

Small-scale

0.408

High

394807

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

486283

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.407

High

531842

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.407

High

742166

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.407

High

750989

PRS7
26S proteasome regulatory subunit 7 homolog

1

4

High-throughput

0.407

High

755147

GCN1
eIF-2-alpha kinase activator GCN1

1

1

High-throughput

0.407

High

817924

IMB4
Importin subunit beta-4

1

1

High-throughput

0.407

High

825669

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.391

High

687071

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

0

High-throughput

0.282

High

932644

NOP56
Nucleolar protein 56

1

0

High-throughput

0.269

Low

932645

H2AZ
Histone H2A.Z

1

0

High-throughput

0.269

Low

558828

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

678527

TAH1
TPR repeat-containing protein associated with Hsp90

1

0

Small-scale

0.249

Low

918949

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

453738

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

737182

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.232

Low

750880

PRS6B
26S proteasome regulatory subunit 6B homolog

1

0

High-throughput

0.232

Low

801093

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.232

Low

932637

RPN8
26S proteasome regulatory subunit RPN8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025