HitPredict

Interactor 1: ROA2 (P22626)
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
Gene: HNRNPA2B1

Interactor 2: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NOPS~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing and 1 others more... GO:0016363 - nuclear matrix
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 353 Hs			1 707
+	Hs
		162035 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38
+	Hs
		161948 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46
+	Hs
		162056 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		NONO_HUMAN (265-707): 1.49e-70: 239: 56.98
+	Hs
		516358 ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00		PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46
+	Hs
		609879 ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00		NONO_HUMAN (265-707): 1.49e-70: 239: 56.98
+	Hs
		162097 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96
+	Hs
		609971 ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00		PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96
+	Hs
		516495 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46
+	Hs
		516339 PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95		PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46
+	Hs
		516689 PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95		PABP3_HUMAN (287-700): 9.1e-69: 239: 16.88
+	Hs
		516511 HNRPD_HUMAN (22-191): 3.34e-37: 138: 41.77		PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46
+	Hs
		1031404 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96
+	Hs
		516608 PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95		PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96
+	Hs
		201707 MSI1H_HUMAN (3-341): 3.78e-60: 199: 28.77		RBM4B_HUMAN (298-436): 1.27e-40: 154: 27.97
+	Dm
		822846 RB87F_DROME (100-199): 6.5e-21: 94.4: 27.00		NONA_DROME (208-658): 1.4e-64: 229: 35.05
+	Hs
		474021 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		PAB4L_HUMAN (251-516): 5.21e-46: 169: 14.20
+	Hs
		516635 PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95		PABP5_HUMAN (244-545): 3.2e-43: 162: 15.34
+	Hs
		516674 PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95		RBM4_HUMAN (298-436): 1.19e-40: 154: 27.97
+	Hs
		1048209 HNRPD_HUMAN (22-191): 3.34e-37: 138: 41.77		RBM4_HUMAN (298-436): 1.19e-40: 154: 27.97