HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: K2C6C (P48668)
Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)
Gene: KRT6C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 564
+	Hs
		517738 CBL_HUMAN (1-906): 0: 917: 100.00		K2C3_HUMAN (135-479): 5.47e-178: 518: 79.83
+	Hs
		380560 CBL_HUMAN (1-906): 0: 917: 100.00		K2C1_HUMAN (128-494): 2.73e-165: 486: 73.57
+	Hs
		610513 CBL_HUMAN (1-906): 0: 917: 100.00		KRT84_HUMAN (1-546): 3.99e-106: 332: 51.37
+	Hs
		380445 CBL_HUMAN (1-906): 0: 917: 100.00		K2C6B_HUMAN (1-499): 1.95e-90: 290: 99.00
+	Hs
		359466 CBL_HUMAN (1-906): 0: 917: 100.00		K2C6A_HUMAN (1-499): 5.37e-86: 279: 98.40
+	Hs
		531534 CBL_HUMAN (1-906): 0: 917: 100.00		K2C5_HUMAN (3-486): 5.94e-85: 277: 77.35
+	Hs
		610433 CBL_HUMAN (1-906): 0: 917: 100.00		K2C79_HUMAN (30-555): 5.08e-82: 267: 61.25
+	Hs
		203197 SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22		K2C8_HUMAN (135-511): 4.68e-165: 479: 68.70
+	Hs
		409194 ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25		K2C8_HUMAN (135-511): 4.68e-165: 479: 68.70
+	Hs
		580149 ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25		K2C4_HUMAN (1-495): 6.17e-73: 243: 63.84