HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: UBC12 (P61081)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
Gene: UBE2M

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	23290524, 16735510
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cbl_N~UQ_con, UBA~UQ_con, UQ_con~zf-C3HC4
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 183
+	Hs
		610305 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		610333 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D2_HUMAN (30-173): 3.54e-75: 223: 32.19
+	Hs
		610481 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E2_HUMAN (5-173): 1.08e-73: 222: 28.66
+	Hs
		610323 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51
+	Hs
		610307 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E1_HUMAN (5-173): 1.45e-72: 218: 28.07
+	Hs
		610469 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E3_HUMAN (5-173): 2.2e-72: 218: 26.90
+	Hs
		919717 CBLB_HUMAN (23-901): 0: 793: 46.65		UB2D2_HUMAN (30-173): 3.54e-75: 223: 32.19
+	Mm
		895981 CBLB_MOUSE (23-901): 0: 791: 45.98		UB2D1_MOUSE (30-173): 2.47e-75: 224: 30.14
+	Hs
		849487 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14
+	Hs
		919905 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D2_HUMAN (30-173): 3.54e-75: 223: 32.19
+	Hs
		895953 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51