HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: PTPRJ (Q12913)
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
Gene: PTPRJ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	Cbl_N~fn3, Cbl_N2~fn3, Cbl_N3~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway GO:0042059 - negative regulation of epidermal growth factor receptor signaling pathway GO:0045296 - cadherin binding GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 1337
+	Mm
		420369 CBL_MOUSE (1-906): 0: 888: 91.59		PTPRC_MOUSE (245-1332): 1.86e-94: 334: 15.29
+	Hs
		610228 CBL_HUMAN (1-906): 0: 917: 100.00		PTPRG_HUMAN (757-1329): 3.11e-55: 213: 17.43
+	Hs
		610409 CBL_HUMAN (1-906): 0: 917: 100.00		PTPRK_HUMAN (25-498): 4.41e-30: 132: 12.10
+	Hs
		610227 CBL_HUMAN (1-906): 0: 917: 100.00		PTPRB_HUMAN (463-930): 1.38e-23: 111: 16.63
+	Hs
		610425 CBL_HUMAN (1-906): 0: 917: 100.00		PTPRO_HUMAN (46-453): 1.96e-21: 103: 14.92
+	Hs
		441178 CBL_HUMAN (1-906): 0: 917: 100.00		PTPRC_HUMAN (47-298): 3.49e-10: 67: 9.89