HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: Q6ICN0 (Q6ICN0)
GRB2 protein
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 217
+	Hs
		610338 CBL_HUMAN (1-906): 0: 917: 100.00		GRB2_HUMAN (1-217): 2.49e-74: 225: 99.54
+	Hs
		610276 CBL_HUMAN (1-906): 0: 917: 100.00		CSK_HUMAN (2-139): 3.84e-24: 100: 36.24
+	Hs
		557607 CBL_HUMAN (1-906): 0: 917: 100.00		NCK1_HUMAN (5-145): 7.2e-23: 96.7: 33.14
+	Hs
		337348 CBL_HUMAN (1-906): 0: 917: 100.00		ABL1_HUMAN (4-139): 4.44e-22: 95.5: 35.46
+	Hs
		610281 CBL_HUMAN (1-906): 0: 917: 100.00		ABL2_HUMAN (4-139): 9.89e-22: 94.7: 34.04
+	Hs
		69201 CBL_HUMAN (1-906): 0: 917: 100.00		A9UF07_HUMAN (4-139): 1.63e-21: 94: 35.46
+	Hs
		548639 CBL_HUMAN (1-906): 0: 917: 100.00		VAV_HUMAN (3-60): 5.24e-16: 78: 43.10
+	Hs
		610517 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN2_HUMAN (2-64): 2.11e-15: 76.5: 34.92
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (90-215): 2.19e-15: 76.1: 19.38
+	Hs
		610540 CBL_HUMAN (1-906): 0: 917: 100.00		CD2AP_HUMAN (158-216): 6.19e-15: 75: 30.00
+	Hs
		442780 CBL_HUMAN (1-906): 0: 917: 100.00		HCK_HUMAN (116-215): 6.52e-14: 71.9: 19.61
+	Hs
		454799 CBL_HUMAN (1-906): 0: 917: 100.00		FGR_HUMAN (161-215): 9.02e-14: 71.5: 33.33
+	Hs
		433254 CBL_HUMAN (1-906): 0: 917: 100.00		YES_HUMAN (76-215): 1.22e-13: 71.1: 16.89
+	Hs
		522778 CBL_HUMAN (1-906): 0: 917: 100.00		SRC_HUMAN (75-215): 5.97e-13: 68.8: 16.78
+	Hs
		610415 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN1_HUMAN (124-216): 9.69e-13: 68.4: 20.43
+	Mm
		337618 CBL_MOUSE (1-906): 0: 888: 91.59		ABL1_MOUSE (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		610308 CBL_HUMAN (1-906): 0: 917: 100.00		VAV2_HUMAN (3-56): 3.52e-11: 63.8: 38.18
+	Hs
		275173 CBL_HUMAN (1-906): 0: 917: 100.00		GRAP2_HUMAN (3-55): 6.91e-11: 62.5: 39.62
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (120-215): 4.69e-10: 60.3: 20.41
+	Mm
		292681 CBL_MOUSE (1-906): 0: 888: 91.59		GRAP2_MOUSE (3-55): 1.2e-10: 61.5: 37.74