Protein: ARHG1
Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)

Gene: ARHG1, ARHGEF1
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q92888

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0003723 - RNA binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

900765

RHOA
Transforming protein RhoA

6

20

Small-scale

0.944

High

1053420

GNA13
Guanine nucleotide-binding protein subunit alpha-13

5

20

Small-scale

0.922

High

915882

RHOB
Rho-related GTP-binding protein RhoB

4

20

Small-scale

0.883

High

436441

RHOC
Rho-related GTP-binding protein RhoC

2

20

High-throughput

0.811

High

974733

GNA12
Guanine nucleotide-binding protein subunit alpha-12

2

20

Small-scale

0.799

High

363248

FINC
Fibronectin

1

9

High-throughput

0.691

High

573039

PRS6A
26S proteasome regulatory subunit 6A

3

1

High-throughput

0.667

High

440945

PLEK
Pleckstrin

1

9

High-throughput

0.665

High

349544

RASH
GTPase HRas

1

15

Small-scale

0.647

High

919662

RAP1A
Ras-related protein Rap-1A

1

20

Small-scale

0.647

High

837637

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

Small-scale

0.618

High

882477

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

18

High-throughput

0.618

High

1171081

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1272182

ARHG1
Rho guanine nucleotide exchange factor 1

1

17

Small-scale

0.618

High

1272187

SH3K1
SH3 domain-containing kinase-binding protein 1

1

19

Small-scale

0.618

High

1272198

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1217127

CCNJL
Cyclin-J-like protein

2

5

High-throughput

0.611

High

832862

TSP3
Thrombospondin-3

3

3

High-throughput

0.609

High

228255

PRKN
E3 ubiquitin-protein ligase parkin

2

15

High-throughput

0.584

High

1230988

DOCK4
Dedicator of cytokinesis protein 4

2

3

High-throughput

0.584

High

231397

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

2

3

High-throughput

0.571

High

1163361

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

2

2

High-throughput

0.571

High

1272204

WBP11
WW domain-binding protein 11

2

5

High-throughput

0.571

High

976183

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

2

0

High-throughput

0.547

High

1272195

RM04
Large ribosomal subunit protein uL4m

2

0

High-throughput

0.547

High

1016090

SRBP2
Sterol regulatory element-binding protein 2

1

1

High-throughput

0.541

High

149901

RFXK
DNA-binding protein RFXANK

1

11

High-throughput

0.536

High

428345

TBB5
Tubulin beta chain

1

6

High-throughput

0.536

High

801283

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.536

High

864096

AP2S1
AP-2 complex subunit sigma

1

7

High-throughput

0.536

High

1039738

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1192004

MILR1
Allergin-1

1

3

High-throughput

0.536

High

1272186

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1272188

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.536

High

1272190

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.536

High

1272193

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

18

High-throughput

0.536

High

1272194

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

1272196

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

1272203

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

3

High-throughput

0.536

High

327199

TXD12
Thioredoxin domain-containing protein 12

2

2

High-throughput

0.521

High

627321

MCM3
DNA replication licensing factor MCM3

2

5

High-throughput

0.521

High

1272189

CLCC1
Chloride channel CLIC-like protein 1

2

1

High-throughput

0.521

High

1218871

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1253460

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.513

High

1272183

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.513

High

1272199

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

830440

KC1E
Casein kinase I isoform epsilon

1

15

High-throughput

0.508

High

135741

EST2
Cocaine esterase

1

4

High-throughput

0.489

High

566779

JUNB
Transcription factor JunB

1

1

High-throughput

0.489

High

975461

PPARD
Peroxisome proliferator-activated receptor delta

1

13

High-throughput

0.489

High

1100109

INF2
Inverted formin-2

1

4

High-throughput

0.489

High

1202775

WDR5B
WD repeat-containing protein 5B

1

13

High-throughput

0.489

High

1231191

KLH34
Kelch-like protein 34

1

7

High-throughput

0.489

High

163082

XPO1
Exportin-1

1

10

High-throughput

0.479

High

273191

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.479

High

314369

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

Small-scale

0.479

High

347496

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

385287

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

430292

PROF1
Profilin-1

1

5

High-throughput

0.479

High

555175

CD44
CD44 antigen

1

5

Small-scale

0.479

High

569933

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

607706

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.479

High

614405

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

6

High-throughput

0.479

High

787283

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

6

Small-scale

0.479

High

904947

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

911034

RS29
Small ribosomal subunit protein uS14

1

2

High-throughput

0.479

High

1021632

TAF10
Transcription initiation factor TFIID subunit 10

1

2

High-throughput

0.479

High

1036777

SQSTM
Sequestosome-1

1

6

High-throughput

0.479

High

1061194

NUMA1
Nuclear mitotic apparatus protein 1

1

15

High-throughput

0.479

High

1064553

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1137543

RIF1
Telomere-associated protein RIF1

1

12

High-throughput

0.479

High

1165813

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1239704

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1264153

DNJC9
DnaJ homolog subfamily C member 9

1

5

High-throughput

0.479

High

1272184

FBXW7
F-box/WD repeat-containing protein 7

1

12

High-throughput

0.479

High

1272185

LRC59
Leucine-rich repeat-containing protein 59

1

7

High-throughput

0.479

High

1272197

GAN
Gigaxonin

1

6

High-throughput

0.479

High

1272201

CTNL1
Alpha-catulin

1

6

Small-scale

0.479

High

1272202

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1086259

H31T
Histone H3.1t

1

2

High-throughput

0.470

High

1184245

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

371435

ANGI
Angiogenin

1

1

High-throughput

0.445

High

1108475

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

2

High-throughput

0.445

High

391072

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

553343

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

651857

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

721071

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

824245

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

975703

LMNB2
Lamin-B2

1

11

High-throughput

0.437

High

1188657

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

1218693

MGAP
MAX gene-associated protein

1

2

High-throughput

0.437

High

1272200

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

1

High-throughput

0.437

High

1272206

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

2

High-throughput

0.437

High

1133091

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

1

High-throughput

0.407

High

1038147

ATR
Serine/threonine-protein kinase ATR

1

4

Small-scale

0.373

High

551229

ITF2
Transcription factor 4

1

0

High-throughput

0.299

High

225016

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

1272191

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1272192

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

1272205

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024