Protein: SIK2
Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)

Gene: SIK2
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q9H0K1

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

943659

SIK1
Serine/threonine-protein kinase SIK1

2

18

High-throughput

0.811

High

717991

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

11

Small-scale

0.737

High

935112

TERA
Transitional endoplasmic reticulum ATPase

4

6

Small-scale

0.697

High

775307

FUS
RNA-binding protein FUS

1

2

High-throughput

0.691

High

876992

KC1A
Casein kinase I isoform alpha

1

11

High-throughput

0.691

High

1417871

DUS16
Dual specificity protein phosphatase 16

1

4

High-throughput

0.691

High

971985

1433E
14-3-3 protein epsilon

3

20

Small-scale

0.667

High

1415074

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.656

High

691418

1433T
14-3-3 protein theta

3

20

Small-scale

0.656

High

1430176

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

5

7

Small-scale

0.650

High

1198346

CRTC2
CREB-regulated transcription coactivator 2

2

6

Small-scale

0.629

High

131077

TULP2
Tubby-related protein 2

2

1

High-throughput

0.628

High

171326

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

4

Small-scale

0.618

High

239334

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

4

Small-scale

0.618

High

272453

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.618

High

463219

YES
Tyrosine-protein kinase Yes

1

6

Small-scale

0.618

High

555754

ACTN1
Alpha-actinin-1

1

4

Small-scale

0.618

High

605807

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

16

High-throughput

0.618

High

666765

MYL9
Myosin regulatory light polypeptide 9

1

9

Small-scale

0.618

High

953093

ACTB
Actin, cytoplasmic 1

1

4

Small-scale

0.618

High

955568

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.618

High

958190

ARP3
Actin-related protein 3

1

3

Small-scale

0.618

High

958347

ARP2
Actin-related protein 2

1

5

Small-scale

0.618

High

1095454

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

18

Small-scale

0.618

High

1201052

ACTBL
Beta-actin-like protein 2

1

4

Small-scale

0.618

High

990715

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.611

High

1100363

TIF1B
Transcription intermediary factor 1-beta

2

5

Small-scale

0.611

High

1430175

HDAC5
Histone deacetylase 5

2

10

Small-scale

0.602

High

991098

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

3

7

Small-scale

0.578

High

718175

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

11

Small-scale

0.575

High

728619

AKT2
RAC-beta serine/threonine-protein kinase

1

14

Small-scale

0.575

High

1430166

SIK2
Serine/threonine-protein kinase SIK2

1

17

Small-scale

0.575

High

653735

PROZ
Vitamin K-dependent protein Z

2

1

High-throughput

0.574

High

952337

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.573

High

994369

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

9

Small-scale

0.571

High

1067702

EP300
Histone acetyltransferase p300

1

6

Small-scale

0.561

High

1248112

CRTC3
CREB-regulated transcription coactivator 3

1

5

Small-scale

0.561

High

1380153

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.561

High

966859

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

1049766

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

1414958

CP250
Centrosome-associated protein CEP250

1

9

Small-scale

0.551

High

682608

S100P
Protein S100-P

1

2

High-throughput

0.536

High

730227

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

916344

TXTP
Tricarboxylate transport protein, mitochondrial

1

6

High-throughput

0.536

High

931102

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.536

High

997124

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.536

High

1382380

SPSB4
SPRY domain-containing SOCS box protein 4

1

8

High-throughput

0.536

High

1430168

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1023880

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

2

7

High-throughput

0.520

High

415851

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.513

High

895045

EMD
Emerin

1

0

High-throughput

0.513

High

423128

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

706307

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

1128951

I13R2
Interleukin-13 receptor subunit alpha-2

1

2

High-throughput

0.489

High

1353758

SHRM3
Protein Shroom3

1

2

High-throughput

0.489

High

1430172

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

4

High-throughput

0.489

High

173340

XPO1
Exportin-1

1

7

High-throughput

0.479

High

179246

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

4

Small-scale

0.479

High

179399

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

Small-scale

0.479

High

187558

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.479

High

192747

ARPC5
Actin-related protein 2/3 complex subunit 5

1

1

Small-scale

0.479

High

222200

NCK2
Cytoplasmic protein NCK2

1

10

High-throughput

0.479

High

224794

ACTN4
Alpha-actinin-4

1

4

Small-scale

0.479

High

476029

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

1

Small-scale

0.479

High

637724

FLNA
Filamin-A

1

5

Small-scale

0.479

High

730878

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

761866

HSP74
Heat shock 70 kDa protein 4

1

6

Small-scale

0.479

High

773012

MYH9
Myosin-9

1

11

Small-scale

0.479

High

773274

MYH10
Myosin-10

1

11

Small-scale

0.479

High

776855

MYH11
Myosin-11

1

11

Small-scale

0.479

High

786840

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

9

Small-scale

0.479

High

862977

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

2

Small-scale

0.479

High

937595

CAD13
Cadherin-13

1

4

Small-scale

0.479

High

967960

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

9

Small-scale

0.479

High

968441

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

9

Small-scale

0.479

High

991704

DYL1
Dynein light chain 1, cytoplasmic

1

1

Small-scale

0.479

High

1109569

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

Small-scale

0.479

High

1124717

SRC8
Src substrate cortactin

1

5

Small-scale

0.479

High

1277781

MYH14
Myosin-14

1

11

Small-scale

0.479

High

1367881

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

3

Small-scale

0.479

High

1400478

SMG1
Serine/threonine-protein kinase SMG1

1

5

Small-scale

0.479

High

1409688

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

1

Small-scale

0.479

High

1430167

YTDC2
3'-5' RNA helicase YTHDC2

1

3

Small-scale

0.479

High

1430171

XPO7
Exportin-7

1

6

High-throughput

0.479

High

1430173

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.479

High

179561

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.458

High

569216

CD59
CD59 glycoprotein

1

0

Small-scale

0.458

High

580693

AMPN
Aminopeptidase N

1

0

Small-scale

0.458

High

583337

FOLR1
Folate receptor alpha

1

0

Small-scale

0.458

High

948470

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

Small-scale

0.458

High

1010368

BASP1
Brain acid soluble protein 1

1

0

Small-scale

0.458

High

1094260

ACACA
Acetyl-CoA carboxylase 1

1

6

Small-scale

0.445

High

176544

GRRE1
Granule associated Rac and RHOG effector protein 1

1

3

High-throughput

0.437

High

464209

TPM2
Tropomyosin beta chain

1

8

Small-scale

0.437

High

472250

MYL3
Myosin light chain 3

1

9

Small-scale

0.437

High

483391

CLCB
Clathrin light chain B

1

2

Small-scale

0.437

High

572333

CBPM
Carboxypeptidase M

1

1

Small-scale

0.437

High

952645

MYL6
Myosin light polypeptide 6

1

9

Small-scale

0.437

High

1052103

CALD1
Caldesmon

1

14

Small-scale

0.437

High

1400331

FMNL2
Formin-like protein 2

1

2

Small-scale

0.437

High

1430170

LIMA1
LIM domain and actin-binding protein 1

1

2

Small-scale

0.437

High

1430174

COR1C
Coronin-1C

1

6

Small-scale

0.437

High

699848

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.426

High

388800

C1QC
Complement C1q subcomponent subunit C

1

2

High-throughput

0.407

High

1155039

ADIPO
Adiponectin

1

2

High-throughput

0.407

High

1226733

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

7

High-throughput

0.407

High

347313

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

1390349

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

426036

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

0

Small-scale

0.249

Low

1430169

ENAM
Enamelin

1

0

Small-scale

0.249

Low

388294

GLPA
Glycophorin-A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025