HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28724758
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030971 - receptor tyrosine kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 630
+	Hs
		610247 CBL_HUMAN (1-906): 0: 917: 100.00		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Mm
		610582 CBL_MOUSE (1-906): 0: 888: 91.59		SHC1_MOUSE (26-620): 4.38e-150: 447: 46.55
+	Rn
		88777 D3ZV15_RAT (1-883): 0: 833: 89.00		SHC1_RAT (148-620): 1.16e-130: 394: 49.38
+	Hs
		561381 CBL_HUMAN (1-906): 0: 917: 100.00		FER_HUMAN (341-629): 8.51e-51: 190: 19.52
+	Hs
		145972 CBL_HUMAN (1-906): 0: 917: 100.00		SH2B2_HUMAN (339-622): 5.86e-49: 182: 19.80
+	Hs
		522778 CBL_HUMAN (1-906): 0: 917: 100.00		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		433254 CBL_HUMAN (1-906): 0: 917: 100.00		YES_HUMAN (367-628): 2.22e-43: 165: 16.12
+	Hs
		208994 CBL_HUMAN (1-906): 0: 917: 100.00		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Hs
		557607 CBL_HUMAN (1-906): 0: 917: 100.00		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Mm
		403415 CBL_MOUSE (1-906): 0: 888: 91.59		SRC_MOUSE (385-628): 1.58e-45: 171: 15.59
+	Mm
		610649 CBL_MOUSE (1-906): 0: 888: 91.59		SH2B2_MOUSE (340-618): 1.18e-39: 155: 17.75
+	Mm
		610633 CBL_MOUSE (1-906): 0: 888: 91.59		NCK1_MOUSE (425-615): 6.64e-40: 151: 17.35
+	Hs
		610238 CBL_HUMAN (1-906): 0: 917: 100.00		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		610338 CBL_HUMAN (1-906): 0: 917: 100.00		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48
+	Hs
		610437 CBL_HUMAN (1-906): 0: 917: 100.00		Q6ICN0_HUMAN (520-616): 5.11e-14: 73.4: 30.48
+	Mm
		610546 CBL_MOUSE (1-906): 0: 888: 91.59		P85A_MOUSE (506-622): 3.58e-20: 97.1: 24.19
+	Mm
		140057 CBL_MOUSE (1-906): 0: 888: 91.59		P85B_MOUSE (511-618): 1.17e-13: 76.1: 27.83
+	Mm
		610598 CBL_MOUSE (1-906): 0: 888: 91.59		GRB2_MOUSE (520-614): 1.23e-13: 72.2: 30.30
+	Rn
		88780 D3ZV15_RAT (1-883): 0: 833: 89.00		P85A_RAT (506-622): 2.61e-20: 97.5: 24.19
+	Rn
		88774 D3ZV15_RAT (1-883): 0: 833: 89.00		GRB2_RAT (520-616): 5.11e-14: 73.4: 30.48