HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: 1433Z (P63101)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2)
Gene: Ywhaz

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0007165 - signal transduction GO:0019901 - protein kinase binding GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 245
+	Mm
		610571 CBL_MOUSE (1-913): 0: 923: 100.00		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Mm
		610576 CBL_MOUSE (1-913): 0: 923: 100.00		1433T_MOUSE (1-245): 8.98e-140: 393: 79.59
+	Hs
		610341 CBL_HUMAN (1-913): 0: 894: 91.05		1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59
+	Hs
		610330 CBL_HUMAN (1-913): 0: 894: 91.05		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		610234 CBL_HUMAN (1-913): 0: 894: 91.05		1433T_HUMAN (1-245): 2.6e-140: 395: 80.00
+	Hs
		610254 CBL_HUMAN (1-913): 0: 894: 91.05		1433B_HUMAN (1-242): 9.01e-140: 393: 88.02
+	Mm
		610638 CBL_MOUSE (1-913): 0: 923: 100.00		1433B_MOUSE (1-242): 1.98e-128: 364: 86.78
+	Mm
		610568 CBL_MOUSE (1-913): 0: 923: 100.00		1433G_MOUSE (1-240): 8.4e-109: 315: 74.59
+	Mm
		610578 CBL_MOUSE (1-913): 0: 923: 100.00		1433F_MOUSE (2-240): 5.1e-108: 313: 74.07
+	Hs
		610327 CBL_HUMAN (1-913): 0: 894: 91.05		1433G_HUMAN (1-240): 8.4e-109: 315: 74.59
+	Hs
		610365 CBL_HUMAN (1-913): 0: 894: 91.05		1433F_HUMAN (2-240): 5.21e-108: 313: 74.49
+	Hs
		610255 CBL_HUMAN (1-913): 0: 894: 91.05		1433S_HUMAN (1-237): 2.52e-103: 301: 71.55
+	Ce
		1093846 Q6ABG8_CAEEL (41-510): 0: 675: 47.63		14332_CAEEL (3-241): 6.3e-139: 391: 81.17
+	Ce
		1090465 Q19019_CAEEL (49-575): 0: 650: 41.89		14332_CAEEL (3-241): 6.3e-139: 391: 81.17
+	Hs
		297824 K0754_HUMAN (544-913): 1.34e-28: 126: 15.54		1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59
+	Hs
		297821 K0754_HUMAN (544-913): 1.34e-28: 126: 15.54		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		297815 K0754_HUMAN (544-913): 1.34e-28: 126: 15.54		1433B_HUMAN (1-242): 9.01e-140: 393: 88.02
+	Hs
		646827 ZO1_HUMAN (435-850): 6.77e-22: 104: 14.39		1433T_HUMAN (1-245): 2.6e-140: 395: 80.00
+	Hs
		683290 ZO1_HUMAN (435-850): 6.77e-22: 104: 14.39		1433B_HUMAN (1-242): 9.01e-140: 393: 88.02
+	Hs
		683987 ZO1_HUMAN (435-850): 6.77e-22: 104: 14.39		1433S_HUMAN (1-237): 2.52e-103: 301: 71.55