Protein: MCM2
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2)

Gene: MCM2
Organism: Saccharomyces cerevisiae S288C
Interactions: 174
UniProt ID: P29469

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0004386 - helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

712951

MCM4
DNA replication licensing factor MCM4

24

20

Small-scale

0.991

High

713045

CDC45
Cell division control protein 45

22

15

Small-scale

0.990

High

664416

MCM3
DNA replication licensing factor MCM3

16

20

Small-scale

0.985

High

713011

MCM6
DNA replication licensing factor MCM6

13

20

Small-scale

0.980

High

712948

MCM5
Minichromosome maintenance protein 5

14

20

Small-scale

0.979

High

713004

CDT1
Cell division cycle protein CDT1

10

3

Small-scale

0.976

High

713032

SLD5
DNA replication complex GINS protein SLD5

11

15

Small-scale

0.970

High

713063

PSF1
DNA replication complex GINS protein PSF1

9

11

Small-scale

0.964

High

712975

MCM7
DNA replication licensing factor MCM7

8

20

Small-scale

0.961

High

712995

PSF2
DNA replication complex GINS protein PSF2

7

8

Small-scale

0.954

High

713022

H3
Histone H3

6

20

Small-scale

0.950

High

381926

H4
Histone H4

6

8

Small-scale

0.933

High

713007

ORC5
Origin recognition complex subunit 5

4

6

Small-scale

0.901

High

381001

H2B1
Histone H2B.1

4

20

Small-scale

0.893

High

713052

PSF3
DNA replication complex GINS protein PSF3

4

9

Small-scale

0.882

High

642018

DPOE
DNA polymerase epsilon catalytic subunit A

3

11

Small-scale

0.847

High

419377

H2A1
Histone H2A.1

3

20

Small-scale

0.834

High

713018

ORC1
Origin recognition complex subunit 1

2

20

Small-scale

0.817

High

419637

H2A2
Histone H2A.2

3

20

Small-scale

0.817

High

712947

MCM2
DNA replication licensing factor MCM2

2

20

Small-scale

0.800

High

440909

CDC7
Cell division control protein 7

14

20

Small-scale

0.762

High

712953

MCM10
Minichromosome maintenance protein 10

11

13

Small-scale

0.761

High

712952

DBF4
DDK kinase regulatory subunit DBF4

7

3

Small-scale

0.749

High

713020

ORC4
Origin recognition complex subunit 4

1

20

Small-scale

0.734

High

713012

SLD3
DNA replication regulator SLD3

6

3

Small-scale

0.728

High

381438

H2B2
Histone H2B.2

1

20

Small-scale

0.724

High

479254

CDC6
Cell division control protein 6

5

20

Small-scale

0.722

High

677662

MRC1
Mediator of replication checkpoint protein 1

4

3

Small-scale

0.686

High

713046

DIA2
Protein DIA2

3

3

Small-scale

0.679

High

713025

CTF4
DNA polymerase alpha-binding protein

4

6

Small-scale

0.676

High

647717

RFA1
Replication factor A protein 1

4

7

Small-scale

0.676

High

713037

CSM3
Chromosome segregation in meiosis protein 3

4

3

Small-scale

0.676

High

712963

SLD2
DNA replication regulator SLD2

3

3

Small-scale

0.670

High

712960

ORC2
Origin recognition complex subunit 2

3

9

Small-scale

0.670

High

561294

DPOLA
DNA polymerase alpha catalytic subunit A

3

11

Small-scale

0.646

High

713014

TOF1
Topoisomerase 1-associated factor 1

3

8

Small-scale

0.640

High

713036

POB3
FACT complex subunit POB3

4

7

Small-scale

0.629

High

713002

DPB11
DNA replication regulator DPB11

2

5

Small-scale

0.624

High

712968

CENPA
Histone H3-like centromeric protein CSE4

1

20

High-throughput

0.618

High

712957

SPT16
FACT complex subunit SPT16

4

5

Small-scale

0.617

High

712982

ORC6
Origin recognition complex subunit 6

2

0

Small-scale

0.606

High

713019

ORC3
Origin recognition complex subunit 3

2

0

Small-scale

0.602

High

713024

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

2

0

High-throughput

0.595

High

712954

ASF1
Histone chaperone ASF1

1

9

High-throughput

0.575

High

713066

H2AZ
Histone H2A.Z

1

20

High-throughput

0.575

High

488928

SWI6
Regulatory protein SWI6

2

8

High-throughput

0.571

High

526112

HSP72
Heat shock protein SSA2

2

15

High-throughput

0.571

High

544076

SSB1
Ribosome-associated molecular chaperone SSB1

2

16

High-throughput

0.571

High

712994

ATAD2
ATPase histone chaperone YTA7

2

6

High-throughput

0.571

High

712991

SSB2
Ribosome-associated molecular chaperone SSB2

2

16

High-throughput

0.552

High

713003

DPOD3
DNA polymerase delta subunit 3

1

0

Small-scale

0.537

High

523280

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.536

High

712950

CGS5
S-phase entry cyclin-5

1

6

High-throughput

0.536

High

713000

ECO1
N-acetyltransferase ECO1

1

6

Small-scale

0.527

High

713057

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.515

High

713060

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.515

High

560591

KIN1
Serine/threonine protein kinase KIN1

1

4

High-throughput

0.508

High

560658

KIN2
Serine/threonine-protein kinase KIN2

1

4

High-throughput

0.508

High

712992

PSA6
Proteasome subunit alpha type-6

1

3

High-throughput

0.508

High

574650

KSS1
Mitogen-activated protein kinase KSS1

1

12

High-throughput

0.501

High

599334

FUS3
Mitogen-activated protein kinase FUS3

1

10

High-throughput

0.501

High

602353

PHO85
Cyclin-dependent protein kinase PHO85

1

11

High-throughput

0.501

High

642343

MCK1
Protein kinase MCK1

1

7

High-throughput

0.501

High

712958

IME2
Meiosis induction protein kinase IME2/SME1

1

15

Small-scale

0.501

High

713053

YP150
Putative serine/threonine-protein kinase YPL150W

1

3

High-throughput

0.501

High

713030

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

1

0

High-throughput

0.486

High

713056

POC4
Proteasome chaperone 4

1

0

High-throughput

0.486

High

712984

RT107
Regulator of Ty1 transposition protein 107

1

4

Small-scale

0.481

High

712986

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

3

Small-scale

0.481

High

712996

CSM2
Chromosome segregation in meiosis protein 2

1

3

Small-scale

0.481

High

713058

PSY3
Platinum sensitivity protein 3

1

3

Small-scale

0.481

High

358143

ADH1
Alcohol dehydrogenase 1

1

2

High-throughput

0.479

High

364965

KPYK1
Pyruvate kinase 1

1

5

High-throughput

0.479

High

434899

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

439275

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.479

High

441759

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

521112

PRI1
DNA primase small subunit

1

1

Small-scale

0.479

High

556994

AAKG
5'-AMP-activated protein kinase subunit gamma

1

5

High-throughput

0.479

High

569543

GCY1
Glycerol 2-dehydrogenase

1

1

High-throughput

0.479

High

597402

EF3A
Elongation factor 3A

1

8

High-throughput

0.479

High

598973

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

4

High-throughput

0.479

High

646637

VPS15
Serine/threonine-protein kinase VPS15

1

5

High-throughput

0.479

High

649537

CHL1
ATP-dependent DNA helicase CHL1

1

1

Small-scale

0.479

High

656384

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.479

High

661145

SPT6
Transcription elongation factor SPT6

1

1

Small-scale

0.479

High

689315

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

694494

SPT5
Transcription elongation factor SPT5

1

1

Small-scale

0.479

High

706411

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

712964

BMH2
Protein BMH2

1

2

Small-scale

0.479

High

712967

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

712974

DPOA2
DNA polymerase alpha subunit B

1

2

Small-scale

0.479

High

712981

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

8

Small-scale

0.479

High

712993

RFC4
Replication factor C subunit 4

1

2

High-throughput

0.479

High

712997

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

713001

CTK2
CTD kinase subunit beta

1

7

High-throughput

0.479

High

713006

CTF18
Chromosome transmission fidelity protein 18

1

3

Small-scale

0.479

High

713009

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

713010

UFD1
Ubiquitin fusion degradation protein 1

1

3

Small-scale

0.479

High

713013

HST2
NAD-dependent protein deacetylase HST2

1

12

High-throughput

0.479

High

713015

IPI3
Pre-rRNA-processing protein IPI3

1

3

Small-scale

0.479

High

713035

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

713040

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

713043

NOC3
Nucleolar complex-associated protein 3

1

1

Small-scale

0.479

High

713048

PMG2
Phosphoglycerate mutase 2

1

2

High-throughput

0.479

High

713055

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

713061

DBP10
ATP-dependent RNA helicase DBP10

1

10

High-throughput

0.479

High

713062

YPR1
Aldehyde reductase YPR1

1

1

High-throughput

0.479

High

713065

GLT1
Glutamate synthase [NADH]

1

3

High-throughput

0.470

High

712956

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.464

High

531452

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.458

High

668250

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

674393

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

702298

MGLL
Monoglyceride lipase

1

0

High-throughput

0.458

High

712949

RIF1
Telomere length regulator protein RIF1

1

0

High-throughput

0.458

High

712965

THI80
Thiamine pyrophosphokinase

1

0

High-throughput

0.458

High

712970

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

712973

TBS1
Uncharacterized transcriptional regulatory protein TBS1

1

0

High-throughput

0.458

High

712976

TRM7
tRNA

1

0

High-throughput

0.458

High

712977

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.458

High

712979

NCB5R
NADH-cytochrome b5 reductase 1

1

0

High-throughput

0.458

High

712980

GIC1
GTPase-interacting component 1

1

0

High-throughput

0.458

High

712990

PHM8
Phosphate metabolism protein 8

1

0

High-throughput

0.458

High

712999

SERB
Phosphoserine phosphatase

1

0

High-throughput

0.458

High

713005

BUL1
Ubiquitin ligase-binding protein BUL1

1

0

High-throughput

0.458

High

713021

DOS2
Protein DOS2

1

0

High-throughput

0.458

High

713023

RAGAB
GTP-binding protein GTR1

1

0

High-throughput

0.458

High

713028

TFB3
RNA polymerase II transcription factor B subunit 3

1

0

High-throughput

0.458

High

713031

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.458

High

713039

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

713041

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

713049

TGS1
Trimethylguanosine synthase

1

0

High-throughput

0.458

High

713050

TSR3
18S rRNA aminocarboxypropyltransferase

1

0

High-throughput

0.458

High

713051

CMR3
Zinc finger protein CRM3

1

0

High-throughput

0.458

High

392366

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.445

High

448146

HAP2
Transcriptional activator HAP2

1

2

High-throughput

0.445

High

550032

RAP1
DNA-binding protein RAP1

1

2

High-throughput

0.445

High

645593

AFT1
Iron-regulated transcriptional activator AFT1

1

2

High-throughput

0.445

High

671502

SWI4
Regulatory protein SWI4

1

7

High-throughput

0.445

High

675781

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

712959

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.445

High

712962

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

712966

SPT10
Protein SPT10

1

3

High-throughput

0.445

High

712969

LHS1
Heat shock protein 70 homolog LHS1

1

16

High-throughput

0.445

High

712971

SET3
SET domain-containing protein 3

1

7

High-throughput

0.445

High

712983

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

9

High-throughput

0.445

High

712987

TCPG
T-complex protein 1 subunit gamma

1

6

High-throughput

0.445

High

712988

MBP1
Transcription factor MBP1

1

9

High-throughput

0.445

High

713016

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.445

High

713026

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

15

High-throughput

0.445

High

713029

GCN5
Histone acetyltransferase GCN5

1

17

High-throughput

0.445

High

713033

GIS1
Transcriptional activator/repressor GIS1

1

6

High-throughput

0.445

High

713038

SWR1
Helicase SWR1

1

5

High-throughput

0.445

High

713044

RSC58
Chromatin structure-remodeling complex protein RSC58

1

2

High-throughput

0.445

High

713064

CAF1A
Chromatin assembly factor 1 subunit A

1

6

High-throughput

0.445

High

367919

ENO2
Enolase 2

1

5

High-throughput

0.437

High

383571

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

409985

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

712972

OMA1
Mitochondrial metalloendopeptidase OMA1

1

1

High-throughput

0.437

High

712978

RGD1
RHO GTPase-activating protein RGD1

1

5

High-throughput

0.437

High

712998

BNI1
Protein BNI1

1

1

High-throughput

0.437

High

713017

MTQ1
Mitochondrial MRF1 N(5)-glutamine methyltransferase MTQ1

1

1

High-throughput

0.437

High

713059

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

585536

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.249

Low

712955

ATP11
Protein ATP11, mitochondrial

1

0

High-throughput

0.249

Low

712985

AIM46
Altered inheritance of mitochondria protein 46, mitochondrial

1

0

High-throughput

0.249

Low

712989

FIR1
Factor interacting with REF2

1

0

High-throughput

0.249

Low

713008

RL4P
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

713027

YD090
Uncharacterized membrane protein YDR090C

1

0

High-throughput

0.249

Low

713034

RT24
Small ribosomal subunit protein mS35

1

0

High-throughput

0.249

Low

713042

FMP45
SUR7 family protein FMP45

1

0

High-throughput

0.249

Low

713047

PGC1
Phosphatidylglycerol phospholipase C

1

0

High-throughput

0.249

Low

713054

RFM1
Repression factor of MSEs protein 1

1

0

High-throughput

0.249

Low

712961

LIPA
Lipoyl synthase, mitochondrial

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025