HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: UBS3B (Q8BGG7)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: Ubash3b

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	UBA~UBA
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 638
+	Hs
		610459 CBL_HUMAN (1-913): 0: 894: 91.05		UBS3B_HUMAN (1-638): 0: 1043: 97.65
+	Mm
		610596 CBL_MOUSE (1-913): 0: 923: 100.00		UBS3A_MOUSE (1-632): 0: 959: 45.66
+	Hs
		610317 CBL_HUMAN (1-913): 0: 894: 91.05		UBS3A_HUMAN (1-632): 0: 951: 42.92
+	Hs
		883333 CBLB_HUMAN (23-908): 0: 799: 45.92		UBS3A_HUMAN (1-632): 0: 951: 42.92
+	Mm
		610598 CBL_MOUSE (1-913): 0: 923: 100.00		GRB2_MOUSE (145-308): 1.8e-45: 162: 21.56
+	Hs
		610338 CBL_HUMAN (1-913): 0: 894: 91.05		GRB2_HUMAN (145-308): 7.25e-46: 163: 21.56
+	Hs
		610437 CBL_HUMAN (1-913): 0: 894: 91.05		Q6ICN0_HUMAN (145-308): 6.96e-45: 161: 21.56
+	Mm
		610595 CBL_MOUSE (1-913): 0: 923: 100.00		SRBS2_MOUSE (219-306): 1.44e-22: 105: 26.80
+	Mm
		610630 CBL_MOUSE (1-913): 0: 923: 100.00		SH3K1_MOUSE (211-350): 4.44e-21: 99.9: 23.24
+	Mm
		610640 CBL_MOUSE (1-913): 0: 923: 100.00		GRAP_MOUSE (145-306): 3.65e-22: 97.2: 18.56
+	Mm
		610608 CBL_MOUSE (1-913): 0: 923: 100.00		SRBS1_MOUSE (247-306): 4.85e-19: 94.1: 40.00
+	Rn
		88774 D3ZV15_RAT (1-877): 0: 852: 96.24		GRB2_RAT (145-308): 7.25e-46: 163: 21.56
+	Hs
		47590 CBL_HUMAN (1-913): 0: 894: 91.05		A0A8V8TNS8_HUMAN (210-364): 4.36e-28: 119: 22.93
+	Hs
		610472 CBL_HUMAN (1-913): 0: 894: 91.05		SH3K1_HUMAN (210-364): 4.94e-27: 118: 22.93
+	Hs
		235473 CBL_HUMAN (1-913): 0: 894: 91.05		VINEX_HUMAN (218-306): 4.67e-23: 106: 26.97
+	Hs
		298949 CBL_HUMAN (1-913): 0: 894: 91.05		SRBS2_HUMAN (219-306): 1.06e-22: 105: 26.80
+	Hs
		610501 CBL_HUMAN (1-913): 0: 894: 91.05		SRBS1_HUMAN (247-306): 1.23e-18: 92.5: 40.00
+	Mm
		82735 B9EKI5_MOUSE (23-908): 0: 816: 47.71		GRB2_MOUSE (145-308): 1.8e-45: 162: 21.56
+	Hs
		235501 CBLB_HUMAN (23-908): 0: 799: 45.92		VINEX_HUMAN (218-306): 4.67e-23: 106: 26.97
+	Hs
		298976 CBLB_HUMAN (23-908): 0: 799: 45.92		SRBS2_HUMAN (219-306): 1.06e-22: 105: 26.80