Protein: HTRA4
Serine protease HTRA4 (EC 3.4.21.-) (High-temperature requirement factor A4)

Gene: HTRA4
Organism: Homo sapiens
Interactions: 188
UniProt ID: P83105

Gene Ontology (top 5):
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0006508 - proteolysis
GO:0012501 - programmed cell death

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1013283

HTRA4
Serine protease HTRA4

3

17

Small-scale

0.827

High

366576

CFAB
Complement factor B

1

2

High-throughput

0.691

High

528392

TGFB3
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

1

6

High-throughput

0.691

High

1013284

HTRA3
Serine protease HTRA3

1

17

Small-scale

0.691

High

1013317

HTRA1
Serine protease HTRA1

1

17

Small-scale

0.691

High

1013285

XIAP
E3 ubiquitin-protein ligase XIAP

3

15

Small-scale

0.632

High

1013287

OTUD4
OTU domain-containing protein 4

2

0

High-throughput

0.602

High

936903

CASP7
Caspase-7

1

2

High-throughput

0.579

High

340740

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

2

1

High-throughput

0.574

High

1013340

WDR26
WD repeat-containing protein 26

2

1

High-throughput

0.574

High

445162

S10A6
Protein S100-A6

1

9

High-throughput

0.554

High

936937

CASP9
Caspase-9

1

2

High-throughput

0.554

High

610620

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.545

High

276457

PDCD6
Programmed cell death protein 6

1

2

High-throughput

0.536

High

444953

S10A9
Protein S100-A9

1

9

High-throughput

0.536

High

457077

CAN1
Calpain-1 catalytic subunit

1

2

High-throughput

0.536

High

457364

TBB5
Tubulin beta chain

1

4

High-throughput

0.536

High

605992

CAN2
Calpain-2 catalytic subunit

1

2

High-throughput

0.536

High

613332

VINC
Vinculin

1

1

High-throughput

0.536

High

682475

S100P
Protein S100-P

1

9

High-throughput

0.536

High

686800

S10A4
Protein S100-A4

1

9

High-throughput

0.536

High

724557

S10A7
Protein S100-A7

1

9

High-throughput

0.536

High

786069

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.536

High

1013289

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

2

High-throughput

0.536

High

1013290

DNJC3
DnaJ homolog subfamily C member 3

1

2

High-throughput

0.536

High

1013325

S10AD
Protein S100-A13

1

9

High-throughput

0.536

High

1013343

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

High-throughput

0.536

High

1013345

DD19A
ATP-dependent RNA helicase DDX19A

1

2

High-throughput

0.536

High

1013360

HYOU1
Hypoxia up-regulated protein 1

1

2

High-throughput

0.536

High

128204

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.513

High

162341

PDCD5
Programmed cell death protein 5

1

0

High-throughput

0.513

High

192710

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.513

High

224690

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.513

High

413615

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

489036

LKHA4
Leukotriene A-4 hydrolase

1

0

High-throughput

0.513

High

954788

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.513

High

1013328

CPPED
Serine/threonine-protein phosphatase CPPED1

1

0

High-throughput

0.513

High

1013355

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.513

High

186643

HMGB3
High mobility group protein B3

1

2

High-throughput

0.489

High

215416

TPD54
Tumor protein D54

1

1

High-throughput

0.489

High

297570

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

High-throughput

0.489

High

298354

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.489

High

334745

IPO7
Importin-7

1

1

High-throughput

0.489

High

343577

OXSR1
Serine/threonine-protein kinase OSR1

1

2

High-throughput

0.489

High

354663

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.489

High

360406

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.489

High

365753

KAD1
Adenylate kinase isoenzyme 1

1

1

High-throughput

0.489

High

443302

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.489

High

447736

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.489

High

482884

TPM1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.489

High

611832

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.489

High

627954

ANXA7
Annexin A7

1

3

High-throughput

0.489

High

651277

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.489

High

687214

HMGB2
High mobility group protein B2

1

2

High-throughput

0.489

High

691704

MK03
Mitogen-activated protein kinase 3

1

2

High-throughput

0.489

High

700869

PSB4
Proteasome subunit beta type-4

1

1

High-throughput

0.489

High

713761

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

1

High-throughput

0.489

High

729027

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

4

High-throughput

0.489

High

755687

MCM4
DNA replication licensing factor MCM4

1

1

High-throughput

0.489

High

772742

MYH9
Myosin-9

1

2

High-throughput

0.489

High

786539

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.489

High

807368

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.489

High

890302

NU153
Nuclear pore complex protein Nup153

1

4

High-throughput

0.489

High

897738

CDK9
Cyclin-dependent kinase 9

1

7

High-throughput

0.489

High

899685

ANX11
Annexin A11

1

3

High-throughput

0.489

High

899833

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.489

High

901183

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.489

High

909533

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

High-throughput

0.489

High

937212

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.489

High

938047

TPD52
Tumor protein D52

1

1

High-throughput

0.489

High

938702

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

4

High-throughput

0.489

High

946400

MTPN
Myotrophin

1

1

High-throughput

0.489

High

958083

ARP3
Actin-related protein 3

1

4

High-throughput

0.489

High

967664

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.489

High

968254

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.489

High

968682

PRS4
26S proteasome regulatory subunit 4

1

1

High-throughput

0.489

High

968878

PRS8
26S proteasome regulatory subunit 8

1

1

High-throughput

0.489

High

985126

RL10A
Large ribosomal subunit protein uL1

1

1

High-throughput

0.489

High

994177

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

4

High-throughput

0.489

High

996657

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.489

High

1005659

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

2

High-throughput

0.489

High

1013292

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

6

High-throughput

0.489

High

1013293

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.489

High

1013294

DX39B
Spliceosome RNA helicase DDX39B

1

3

High-throughput

0.489

High

1013297

MCM6
DNA replication licensing factor MCM6

1

1

High-throughput

0.489

High

1013299

SF3B4
Splicing factor 3B subunit 4

1

2

High-throughput

0.489

High

1013300

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

2

High-throughput

0.489

High

1013301

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

3

High-throughput

0.489

High

1013303

TAF2
Transcription initiation factor TFIID subunit 2

1

1

High-throughput

0.489

High

1013304

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

High-throughput

0.489

High

1013306

TAOK1
Serine/threonine-protein kinase TAO1

1

2

High-throughput

0.489

High

1013307

MYH14
Myosin-14

1

2

High-throughput

0.489

High

1013308

S1A7A
Protein S100-A7A

1

9

High-throughput

0.489

High

1013312

ZN444
Zinc finger protein 444

1

6

High-throughput

0.489

High

1013313

RN169
E3 ubiquitin-protein ligase RNF169

1

1

High-throughput

0.489

High

1013321

S10AG
Protein S100-A16

1

9

High-throughput

0.489

High

1013322

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

1

High-throughput

0.489

High

1013326

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

3

High-throughput

0.489

High

1013327

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.489

High

1013332

KIFC1
Kinesin-like protein KIFC1

1

1

High-throughput

0.489

High

1013337

PABP3
Polyadenylate-binding protein 3

1

1

High-throughput

0.489

High

1013342

S10AE
Protein S100-A14

1

9

High-throughput

0.489

High

1013346

RBM28
RNA-binding protein 28

1

1

High-throughput

0.489

High

1013347

CDK12
Cyclin-dependent kinase 12

1

5

High-throughput

0.489

High

1013349

SPAST
Spastin

1

3

High-throughput

0.489

High

1013356

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

2

High-throughput

0.489

High

1013357

CD11A
Cyclin-dependent kinase 11A

1

4

High-throughput

0.489

High

1013361

RN114
E3 ubiquitin-protein ligase RNF114

1

4

High-throughput

0.489

High

778050

VGFR2
Vascular endothelial growth factor receptor 2

1

4

Small-scale

0.445

High

942552

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

952741

ACTB
Actin, cytoplasmic 1

1

4

High-throughput

0.437

High

749762

CADH5
Cadherin-5

1

1

Small-scale

0.407

High

1013318

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.328

High

1013319

TTC28
Tetratricopeptide repeat protein 28

2

0

High-throughput

0.328

High

1013339

WDCP
WD repeat and coiled-coil-containing protein

2

0

High-throughput

0.328

High

128569

ATOX1
Copper transport protein ATOX1

1

0

High-throughput

0.279

Low

129714

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.279

Low

134008

IPO5
Importin-5

1

0

High-throughput

0.279

Low

179336

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.279

Low

181088

AXIN1
Axin-1

1

0

High-throughput

0.279

Low

215295

TXNL1
Thioredoxin-like protein 1

1

0

High-throughput

0.279

Low

222468

PLRG1
Pleiotropic regulator 1

1

0

High-throughput

0.279

Low

252044

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.279

Low

252240

CCNT2
Cyclin-T2

1

0

High-throughput

0.279

Low

252518

SEP15
Selenoprotein F

1

0

High-throughput

0.279

Low

271152

COBL
Protein cordon-bleu

1

0

High-throughput

0.279

Low

271247

CPNE3
Copine-3

1

0

High-throughput

0.279

Low

288929

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.279

Low

289502

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

0

High-throughput

0.279

Low

357934

CYB5
Cytochrome b5

1

0

High-throughput

0.279

Low

476646

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.279

Low

576102

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.279

Low

643781

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.279

Low

716825

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.279

Low

717769

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.279

Low

776883

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.279

Low

859228

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.279

Low

859568

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.279

Low

868492

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.279

Low

887516

PSB3
Proteasome subunit beta type-3

1

0

High-throughput

0.279

Low

890449

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.279

Low

900769

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.279

Low

902415

DAP1
Death-associated protein 1

1

0

High-throughput

0.279

Low

913241

TF2AA
Transcription initiation factor IIA subunit 1

1

0

High-throughput

0.279

Low

937177

ADK
Adenosine kinase

1

0

High-throughput

0.279

Low

941133

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.279

Low

949337

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.279

Low

957708

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.279

Low

993886

TYB10
Thymosin beta-10

1

0

High-throughput

0.279

Low

1008577

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.279

Low

1011054

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.279

Low

1012804

RT09
Small ribosomal subunit protein uS9m

1

0

High-throughput

0.279

Low

1013286

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.279

Low

1013288

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.279

Low

1013291

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.279

Low

1013295

CAYP1
Calcyphosin

1

0

High-throughput

0.279

Low

1013296

SEPT6
Septin-6

1

0

High-throughput

0.279

Low

1013298

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.279

Low

1013302

CDC73
Parafibromin

1

0

High-throughput

0.279

Low

1013305

MARK2
Serine/threonine-protein kinase MARK2

1

0

High-throughput

0.279

Low

1013309

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.279

Low

1013310

DJC10
DnaJ homolog subfamily C member 10

1

0

High-throughput

0.279

Low

1013311

SELH
Selenoprotein H

1

0

High-throughput

0.279

Low

1013314

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.279

Low

1013315

SELM
Selenoprotein M

1

0

High-throughput

0.279

Low

1013316

NDRG1
Protein NDRG1

1

0

High-throughput

0.279

Low

1013320

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.279

Low

1013323

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.279

Low

1013324

NIBA2
Protein Niban 2

1

0

High-throughput

0.279

Low

1013329

PELO
Protein pelota homolog

1

0

High-throughput

0.279

Low

1013330

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.279

Low

1013331

PDC10
Programmed cell death protein 10

1

0

High-throughput

0.279

Low

1013333

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.279

Low

1013334

RM09
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.279

Low

1013335

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.279

Low

1013336

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.279

Low

1013338

GOLP3
Golgi phosphoprotein 3

1

0

High-throughput

0.279

Low

1013341

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.279

Low

1013344

SOSSC
SOSS complex subunit C

1

0

High-throughput

0.279

Low

1013348

RCC2
Protein RCC2

1

0

High-throughput

0.279

Low

1013350

PARP2
Poly [ADP-ribose] polymerase 2

1

0

High-throughput

0.279

Low

1013352

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.279

Low

1013353

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.279

Low

1013354

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.279

Low

1013359

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.279

Low

1013358

SYCY1
Syncytin-1

1

0

Small-scale

0.261

Low

1013351

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025