HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SLAP2 (Q8R4L0)
Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2)
Gene: Sla2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12024036
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 259
+	Mm
		536206 CBL_MOUSE (1-913): 0: 923: 100.00		FGR_MOUSE (4-256): 1.79e-84: 263: 31.68
+	Mm
		610545 CBL_MOUSE (1-913): 0: 923: 100.00		LYN_MOUSE (4-256): 1.19e-83: 260: 32.05
+	Mm
		610554 CBL_MOUSE (1-913): 0: 923: 100.00		FYN_MOUSE (18-256): 6.79e-81: 254: 31.84
+	Mm
		435877 CBL_MOUSE (1-913): 0: 923: 100.00		HCK_MOUSE (3-255): 1.96e-79: 250: 31.82
+	Mm
		403415 CBL_MOUSE (1-913): 0: 923: 100.00		SRC_MOUSE (2-256): 1.03e-78: 248: 28.32
+	Mm
		411917 CBL_MOUSE (1-913): 0: 923: 100.00		LCK_MOUSE (3-255): 7.71e-78: 245: 31.40
+	Hs
		433577 CBL_HUMAN (1-913): 0: 894: 91.05		LYN_HUMAN (4-256): 1.31e-83: 260: 31.66
+	Hs
		442780 CBL_HUMAN (1-913): 0: 894: 91.05		HCK_HUMAN (3-255): 1.09e-81: 256: 31.32
+	Hs
		433254 CBL_HUMAN (1-913): 0: 894: 91.05		YES_HUMAN (33-259): 2.69e-81: 255: 33.62
+	Hs
		412013 CBL_HUMAN (1-913): 0: 894: 91.05		FYN_HUMAN (18-256): 6.79e-81: 254: 31.84
+	Hs
		454799 CBL_HUMAN (1-913): 0: 894: 91.05		FGR_HUMAN (33-256): 4.24e-80: 251: 32.17
+	Mm
		610586 CBL_MOUSE (1-913): 0: 923: 100.00		ITK_MOUSE (4-255): 1.38e-67: 221: 22.52
+	Hs
		411595 CBL_HUMAN (1-913): 0: 894: 91.05		LCK_HUMAN (22-255): 6.78e-78: 245: 32.22
+	Mm
		337618 CBL_MOUSE (1-913): 0: 923: 100.00		ABL1_MOUSE (9-256): 2.23e-61: 210: 24.02
+	Mm
		610600 CBL_MOUSE (1-913): 0: 923: 100.00		SLAP1_MOUSE (13-255): 1.2e-65: 207: 42.63
+	Mm
		610555 CBL_MOUSE (1-913): 0: 923: 100.00		CSK_MOUSE (24-255): 2.08e-58: 193: 25.00
+	Hs
		337348 CBL_HUMAN (1-913): 0: 894: 91.05		ABL1_HUMAN (9-256): 1.39e-61: 211: 24.02
+	Hs
		69201 CBL_HUMAN (1-913): 0: 894: 91.05		A9UF07_HUMAN (9-256): 5.17e-60: 206: 24.02
+	Mm
		292681 CBL_MOUSE (1-913): 0: 923: 100.00		GRAP2_MOUSE (36-175): 7.58e-14: 72: 34.29
+	Hs
		275173 CBL_HUMAN (1-913): 0: 894: 91.05		GRAP2_HUMAN (36-175): 4.97e-15: 75.1: 35.71