Protein: NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)

Gene: NFAC2, NFATC2
Organism: Homo sapiens
Interactions: 199
UniProt ID: Q13469

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

429836

JUN
Transcription factor Jun

3

20

Small-scale

0.865

High

1106325

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

3

16

Small-scale

0.857

High

340883

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

3

18

Small-scale

0.827

High

593100

CREB1
Cyclic AMP-responsive element-binding protein 1

2

4

High-throughput

0.789

High

613024

EGR1
Early growth response protein 1

3

7

Small-scale

0.640

High

1106347

I2BP2
Interferon regulatory factor 2-binding protein 2

2

5

Small-scale

0.631

High

370656

FOS
Protein c-Fos

1

20

High-throughput

0.618

High

603646

JUNB
Transcription factor JunB

1

20

High-throughput

0.618

High

605078

JUND
Transcription factor JunD

1

20

High-throughput

0.618

High

605254

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

20

High-throughput

0.618

High

738977

ELF1
ETS-related transcription factor Elf-1

1

15

Small-scale

0.618

High

832983

ETV6
Transcription factor ETV6

1

12

High-throughput

0.618

High

1017415

FOXK1
Forkhead box protein K1

1

12

High-throughput

0.618

High

1106333

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

17

High-throughput

0.618

High

1106336

CEBPE
CCAAT/enhancer-binding protein epsilon

1

13

High-throughput

0.618

High

1106362

CBP
CREB-binding protein

2

20

Small-scale

0.602

High

1106335

IRF4
Interferon regulatory factor 4

2

20

Small-scale

0.601

High

1106349

VRK2
Serine/threonine-protein kinase VRK2

1

13

Small-scale

0.586

High

378084

TNFA
Tumor necrosis factor

2

15

Small-scale

0.584

High

853791

MK09
Mitogen-activated protein kinase 9

2

11

Small-scale

0.584

High

952412

IL2
Interleukin-2

2

6

Small-scale

0.584

High

1067281

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

396052

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1051222

KPCZ
Protein kinase C zeta type

1

12

Small-scale

0.561

High

1106331

MEF2D
Myocyte-specific enhancer factor 2D

1

1

Small-scale

0.561

High

1106341

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

Small-scale

0.554

High

474654

VIME
Vimentin

1

6

High-throughput

0.541

High

1106397

MED31
Mediator of RNA polymerase II transcription subunit 31

1

3

High-throughput

0.541

High

1062366

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

13

Small-scale

0.536

High

717797

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

5

Small-scale

0.536

High

862832

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

Small-scale

0.536

High

934067

XPO2
Exportin-2

1

13

Small-scale

0.536

High

1106366

TNPO1
Transportin-1

1

6

Small-scale

0.536

High

1106393

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

2

Small-scale

0.515

High

155937

SOCS3
Suppressor of cytokine signaling 3

1

11

Small-scale

0.501

High

1106326

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.501

High

1106337

TAF9
Transcription initiation factor TFIID subunit 9

1

1

Small-scale

0.501

High

130457

SPT5H
Transcription elongation factor SPT5

1

13

High-throughput

0.479

High

154684

ARI1A
AT-rich interactive domain-containing protein 1A

1

14

High-throughput

0.479

High

163098

CHK1
Serine/threonine-protein kinase Chk1

1

3

High-throughput

0.479

High

173700

BTAF1
TATA-binding protein-associated factor 172

1

15

High-throughput

0.479

High

180282

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.479

High

193338

MAFG
Transcription factor MafG

1

3

High-throughput

0.479

High

214422

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

3

High-throughput

0.479

High

216429

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

Small-scale

0.479

High

229431

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

1

High-throughput

0.479

High

243626

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

13

High-throughput

0.479

High

246581

KDM1A
Lysine-specific histone demethylase 1A

1

10

High-throughput

0.479

High

253403

MAFK
Transcription factor MafK

1

3

High-throughput

0.479

High

262514

MCE1
mRNA-capping enzyme

1

1

High-throughput

0.479

High

277679

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.479

High

288941

ERAL1
GTPase Era, mitochondrial

1

1

High-throughput

0.479

High

316841

MTA2
Metastasis-associated protein MTA2

1

5

High-throughput

0.479

High

331569

KIF4A
Chromosome-associated kinesin KIF4A

1

5

High-throughput

0.479

High

332991

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

6

High-throughput

0.479

High

348491

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

High-throughput

0.479

High

352132

MBD3
Methyl-CpG-binding domain protein 3

1

2

High-throughput

0.479

High

355207

ACL6A
Actin-like protein 6A

1

9

High-throughput

0.479

High

485119

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

Small-scale

0.479

High

487273

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

535023

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

537107

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

558108

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

559342

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.479

High

565889

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

588625

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

600296

ZNF24
Zinc finger protein 24

1

3

High-throughput

0.479

High

610647

TCPA
T-complex protein 1 subunit alpha

1

7

High-throughput

0.479

High

622803

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

8

High-throughput

0.479

High

651795

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

4

High-throughput

0.479

High

670075

NFYB
Nuclear transcription factor Y subunit beta

1

1

High-throughput

0.479

High

690978

1433T
14-3-3 protein theta

1

18

High-throughput

0.479

High

695382

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

697522

PYR1
Multifunctional protein CAD

1

5

High-throughput

0.479

High

727790

DNJA1
DnaJ homolog subfamily A member 1

1

6

High-throughput

0.479

High

729805

1433B
14-3-3 protein beta/alpha

1

18

High-throughput

0.479

High

769716

RFC4
Replication factor C subunit 4

1

6

High-throughput

0.479

High

769848

RFC2
Replication factor C subunit 2

1

6

High-throughput

0.479

High

775661

DEK
Protein DEK

1

1

High-throughput

0.479

High

801302

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

829072

RFC5
Replication factor C subunit 5

1

6

High-throughput

0.479

High

829206

RFC3
Replication factor C subunit 3

1

6

High-throughput

0.479

High

851761

NKX21
Homeobox protein Nkx-2.1

1

7

High-throughput

0.479

High

853249

CBX5
Chromobox protein homolog 5

1

8

High-throughput

0.479

High

853675

MK08
Mitogen-activated protein kinase 8

1

11

Small-scale

0.479

High

877103

KC1D
Casein kinase I isoform delta

1

10

High-throughput

0.479

High

888037

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.479

High

890469

RBP2
E3 SUMO-protein ligase RanBP2

1

4

High-throughput

0.479

High

891518

GSK3B
Glycogen synthase kinase-3 beta

1

10

High-throughput

0.479

High

892559

DNLI3
DNA ligase 3

1

1

High-throughput

0.479

High

893606

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

894724

EMD
Emerin

1

1

High-throughput

0.479

High

903351

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

13

High-throughput

0.479

High

913766

ZN131
Zinc finger protein 131

1

2

High-throughput

0.479

High

919935

PLK1
Serine/threonine-protein kinase PLK1

1

8

High-throughput

0.479

High

926657

HIRA
Protein HIRA

1

2

High-throughput

0.479

High

943715

PRD15
PR domain zinc finger protein 15

1

1

High-throughput

0.479

High

964607

DCAF7
DDB1- and CUL4-associated factor 7

1

4

High-throughput

0.479

High

966277

1433G
14-3-3 protein gamma

1

18

High-throughput

0.479

High

967710

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.479

High

971487

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

981815

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

990186

1433Z
14-3-3 protein zeta/delta

1

18

High-throughput

0.479

High

1008132

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.479

High

1014091

CBX1
Chromobox protein homolog 1

1

8

High-throughput

0.479

High

1024026

TFAM
Transcription factor A, mitochondrial

1

12

High-throughput

0.479

High

1029825

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

1032751

SATB1
DNA-binding protein SATB1

1

1

High-throughput

0.479

High

1048496

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1050283

CSTF1
Cleavage stimulation factor subunit 1

1

5

High-throughput

0.479

High

1050838

EGR4
Early growth response protein 4

1

9

Small-scale

0.479

High

1065177

SSRP1
FACT complex subunit SSRP1

1

12

High-throughput

0.479

High

1088828

TP53B
TP53-binding protein 1

1

7

High-throughput

0.479

High

1094757

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.479

High

1097275

CBX3
Chromobox protein homolog 3

1

8

High-throughput

0.479

High

1102526

MTA1
Metastasis-associated protein MTA1

1

5

High-throughput

0.479

High

1103146

CTBP1
C-terminal-binding protein 1

1

8

High-throughput

0.479

High

1104566

IKZF1
DNA-binding protein Ikaros

1

6

High-throughput

0.479

High

1106327

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

1106328

TF2H2
General transcription factor IIH subunit 2

1

1

High-throughput

0.479

High

1106329

NFYC
Nuclear transcription factor Y subunit gamma

1

4

High-throughput

0.479

High

1106330

HLTF
Helicase-like transcription factor

1

17

High-throughput

0.479

High

1106332

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

6

High-throughput

0.479

High

1106334

IMB1
Importin subunit beta-1

1

5

Small-scale

0.479

High

1106338

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

1106339

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

8

High-throughput

0.479

High

1106340

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

High-throughput

0.479

High

1106342

BEND3
BEN domain-containing protein 3

1

1

High-throughput

0.479

High

1106343

T2H2L
General transcription factor IIH subunit 2-like protein

1

1

High-throughput

0.479

High

1106344

TBA1A
Tubulin alpha-1A chain

1

17

Small-scale

0.479

High

1106345

SPT6H
Transcription elongation factor SPT6

1

2

High-throughput

0.479

High

1106346

POGZ
Pogo transposable element with ZNF domain

1

3

High-throughput

0.479

High

1106348

TLK2
Serine/threonine-protein kinase tousled-like 2

1

11

High-throughput

0.479

High

1106350

P66A
Transcriptional repressor p66-alpha

1

2

High-throughput

0.479

High

1106351

I2BP1
Interferon regulatory factor 2-binding protein 1

1

2

High-throughput

0.479

High

1106352

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

1

Small-scale

0.479

High

1106353

RPTOR
Regulatory-associated protein of mTOR

1

10

High-throughput

0.479

High

1106355

SCAI
Protein SCAI

1

1

High-throughput

0.479

High

1106356

WDR48
WD repeat-containing protein 48

1

9

High-throughput

0.479

High

1106357

SMRC2
SWI/SNF complex subunit SMARCC2

1

20

High-throughput

0.479

High

1106359

P66B
Transcriptional repressor p66-beta

1

2

High-throughput

0.479

High

1106360

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.479

High

1106361

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

1106363

RAD50
DNA repair protein RAD50

1

9

High-throughput

0.479

High

1106364

SMRC1
SWI/SNF complex subunit SMARCC1

1

13

High-throughput

0.479

High

1106365

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

8

High-throughput

0.479

High

1106367

IRF7
Interferon regulatory factor 7

1

20

Small-scale

0.479

High

1106368

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

11

High-throughput

0.479

High

1106369

MCRS1
Microspherule protein 1

1

1

High-throughput

0.479

High

1106370

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

6

High-throughput

0.479

High

1106371

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

16

High-throughput

0.479

High

1106372

CIC
Protein capicua homolog

1

16

High-throughput

0.479

High

1106373

RANB9
Ran-binding protein 9

1

11

High-throughput

0.479

High

1106374

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

11

High-throughput

0.479

High

1106375

HTF4
Transcription factor 12

1

2

High-throughput

0.479

High

1106376

KIF2C
Kinesin-like protein KIF2C

1

7

High-throughput

0.479

High

1106377

BC11B
B-cell lymphoma/leukemia 11B

1

2

High-throughput

0.479

High

1106378

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.479

High

1106379

WDR26
WD repeat-containing protein 26

1

9

High-throughput

0.479

High

1106383

VAPA
Vesicle-associated membrane protein-associated protein A

1

6

High-throughput

0.479

High

1106385

ZMYM2
Zinc finger MYM-type protein 2

1

3

High-throughput

0.479

High

1106386

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1106387

HERC5
E3 ISG15--protein ligase HERC5

1

5

Small-scale

0.479

High

1106388

LEF1
Lymphoid enhancer-binding factor 1

1

9

High-throughput

0.479

High

1106389

TLK1
Serine/threonine-protein kinase tousled-like 1

1

7

High-throughput

0.479

High

1106390

RCOR1
REST corepressor 1

1

9

High-throughput

0.479

High

1106392

IKZF2
Zinc finger protein Helios

1

6

High-throughput

0.479

High

1106394

ZN148
Zinc finger protein 148

1

5

High-throughput

0.479

High

1106395

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

1106396

PDIP2
Polymerase delta-interacting protein 2

1

2

High-throughput

0.479

High

1106398

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.479

High

1106400

CABIN
Calcineurin-binding protein cabin-1

1

13

High-throughput

0.479

High

715437

CD40L
CD40 ligand

1

15

Small-scale

0.470

High

277171

ZN217
Zinc finger protein 217

1

0

High-throughput

0.458

High

442698

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.458

High

483568

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.458

High

617695

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.458

High

768117

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

892858

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.458

High

926082

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.458

High

984102

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

Small-scale

0.458

High

1031991

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1066290

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.458

High

1106358

ZN384
Zinc finger protein 384

1

0

High-throughput

0.458

High

1106380

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1106391

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.458

High

1106399

TF3C5
General transcription factor 3C polypeptide 5

1

0

High-throughput

0.458

High

281947

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.437

High

569307

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

1

3

High-throughput

0.437

High

829376

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

4

High-throughput

0.437

High

880435

CX3C1
CX3C chemokine receptor 1

1

8

Small-scale

0.437

High

882658

EFTU
Elongation factor Tu, mitochondrial

1

8

High-throughput

0.437

High

932860

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

1

High-throughput

0.437

High

1106354

LRC47
Leucine-rich repeat-containing protein 47

1

4

High-throughput

0.437

High

724059

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.249

Low

1106381

RM17
Large ribosomal subunit protein bL17m

1

0

High-throughput

0.249

Low

1106382

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.249

Low

1106384

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025