Protein: NFKB2
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]

Gene: NFKB2
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q00653

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002268 - follicular dendritic cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

626179

NFKB1
Nuclear factor NF-kappa-B p105 subunit

15

19

Small-scale

0.984

High

1026701

TF65
Transcription factor p65

15

17

Small-scale

0.982

High

1026698

RELB
Transcription factor RelB

14

17

Small-scale

0.981

High

1026702

REL
Proto-oncogene c-Rel

10

17

Small-scale

0.974

High

1026792

FBW1A
F-box/WD repeat-containing protein 1A

8

20

Small-scale

0.968

High

683439

IKBA
NF-kappa-B inhibitor alpha

7

19

Small-scale

0.966

High

1026763

M3K14
Mitogen-activated protein kinase kinase kinase 14

8

20

Small-scale

0.963

High

1026783

FBW1B
F-box/WD repeat-containing protein 11

7

20

Small-scale

0.961

High

634918

BCL3
B-cell lymphoma 3 protein

7

19

Small-scale

0.959

High

1026755

FBXW7
F-box/WD repeat-containing protein 7

7

20

Small-scale

0.952

High

1026726

IKBB
NF-kappa-B inhibitor beta

5

18

High-throughput

0.919

High

177846

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

5

20

Small-scale

0.909

High

127778

IKBE
NF-kappa-B inhibitor epsilon

3

19

Small-scale

0.860

High

1026696

NFKB2
Nuclear factor NF-kappa-B p100 subunit

3

19

Small-scale

0.839

High

1026748

IKBD
NF-kappa-B inhibitor delta

2

18

High-throughput

0.811

High

1026759

ASB2
Ankyrin repeat and SOCS box protein 2

2

14

High-throughput

0.811

High

834740

M3K8
Mitogen-activated protein kinase kinase kinase 8

2

15

High-throughput

0.802

High

1026749

IASPP
RelA-associated inhibitor

2

20

Small-scale

0.789

High

413634

P53
Cellular tumor antigen p53

2

11

Small-scale

0.754

High

1026773

IKBZ
NF-kappa-B inhibitor zeta

1

18

High-throughput

0.698

High

158429

RFXK
DNA-binding protein RFXANK

1

17

High-throughput

0.691

High

1026715

BIRC2
Baculoviral IAP repeat-containing protein 2

1

14

Small-scale

0.691

High

1026780

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

20

High-throughput

0.675

High

1026776

DEFI6
Differentially expressed in FDCP 6 homolog

3

20

High-throughput

0.667

High

141425

DDX3X
ATP-dependent RNA helicase DDX3X

1

3

High-throughput

0.665

High

1026794

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.665

High

1026721

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

20

Small-scale

0.653

High

577425

ETS1
Protein C-ets-1

1

11

Small-scale

0.646

High

578293

ETS2
Protein C-ets-2

1

12

Small-scale

0.646

High

488213

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

3

High-throughput

0.628

High

1026784

PADI3
Protein-arginine deiminase type-3

2

2

High-throughput

0.628

High

1026786

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

3

High-throughput

0.618

High

167870

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

High-throughput

0.618

High

408023

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.618

High

457369

TBB5
Tubulin beta chain

1

20

High-throughput

0.618

High

487198

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.618

High

549120

CDK4
Cyclin-dependent kinase 4

1

8

Small-scale

0.618

High

658116

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.618

High

830573

CCNF
Cyclin-F

1

8

High-throughput

0.618

High

891116

GSK3A
Glycogen synthase kinase-3 alpha

1

13

High-throughput

0.618

High

891456

GSK3B
Glycogen synthase kinase-3 beta

1

14

High-throughput

0.618

High

934471

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.618

High

968684

PRS4
26S proteasome regulatory subunit 4

1

3

High-throughput

0.618

High

968880

PRS8
26S proteasome regulatory subunit 8

1

5

High-throughput

0.618

High

975378

PRS10
26S proteasome regulatory subunit 10B

1

5

High-throughput

0.618

High

992137

SKP1
S-phase kinase-associated protein 1

1

5

High-throughput

0.618

High

1008090

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.618

High

1025322

CDK6
Cyclin-dependent kinase 6

1

8

Small-scale

0.618

High

1026705

DHX9
ATP-dependent RNA helicase A

1

4

High-throughput

0.618

High

1026713

SKP2
S-phase kinase-associated protein 2

1

6

Small-scale

0.618

High

1026717

CUL3
Cullin-3

1

20

High-throughput

0.618

High

1026718

CUL4A
Cullin-4A

1

20

High-throughput

0.618

High

1026719

CUL4B
Cullin-4B

1

20

High-throughput

0.618

High

1026735

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1026736

TBA1A
Tubulin alpha-1A chain

1

20

High-throughput

0.618

High

1026770

TBB6
Tubulin beta-6 chain

1

20

High-throughput

0.618

High

1026771

TBB2B
Tubulin beta-2B chain

1

20

High-throughput

0.618

High

1026775

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

10

High-throughput

0.618

High

1026778

DDX21
Nucleolar RNA helicase 2

1

7

High-throughput

0.618

High

1026782

TBK1
Serine/threonine-protein kinase TBK1

1

20

High-throughput

0.618

High

127933

PSD11
26S proteasome non-ATPase regulatory subunit 11

2

3

Small-scale

0.608

High

552942

PIP
Prolactin-inducible protein

2

4

High-throughput

0.601

High

1026746

TNIP2
TNFAIP3-interacting protein 2

2

5

High-throughput

0.601

High

553170

KCRB
Creatine kinase B-type

1

0

High-throughput

0.586

High

371779

MYC
Myc proto-oncogene protein

2

18

High-throughput

0.584

High

1026779

DDX28
Probable ATP-dependent RNA helicase DDX28

1

5

High-throughput

0.575

High

1026750

ESR2
Estrogen receptor beta

2

20

High-throughput

0.571

High

128975

MEN1
Menin

1

3

Small-scale

0.561

High

1026764

T22D3
TSC22 domain family protein 3

1

4

Small-scale

0.561

High

1026709

EPS8
Epidermal growth factor receptor kinase substrate 8

1

10

High-throughput

0.555

High

163280

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

8

Small-scale

0.553

High

1026733

FBX42
F-box only protein 42

1

5

High-throughput

0.553

High

1026734

KLC3
Kinesin light chain 3

1

3

High-throughput

0.536

High

1026737

COMD2
COMM domain-containing protein 2

1

3

Small-scale

0.536

High

1026743

COMD1
COMM domain-containing protein 1

1

5

Small-scale

0.536

High

1026745

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

13

High-throughput

0.536

High

1026756

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1026766

NPAS1
Neuronal PAS domain-containing protein 1

1

8

High-throughput

0.536

High

1026791

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

2

High-throughput

0.536

High

175009

SC16A
Protein transport protein Sec16A

1

5

High-throughput

0.515

High

827743

STAT3
Signal transducer and activator of transcription 3

1

10

Small-scale

0.515

High

973142

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.515

High

984379

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.515

High

1026699

RL6
Large ribosomal subunit protein eL6

1

2

High-throughput

0.515

High

1026710

TRAF1
TNF receptor-associated factor 1

1

3

Small-scale

0.515

High

787541

TNR3
Tumor necrosis factor receptor superfamily member 3

1

8

Small-scale

0.514

High

182971

NKRF
NF-kappa-B-repressing factor

1

3

Small-scale

0.501

High

403985

GCR
Glucocorticoid receptor

1

20

Small-scale

0.501

High

464910

SP1
Transcription factor Sp1

1

15

Small-scale

0.501

High

1026752

REQU
Zinc finger protein ubi-d4

1

18

Small-scale

0.501

High

1026760

TCPQM
T-complex protein 1 subunit theta-like 2

1

10

High-throughput

0.489

High

172706

XPO1
Exportin-1

1

20

High-throughput

0.479

High

210920

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

High-throughput

0.479

High

241415

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.479

High

252962

PDE8A
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

1

6

Small-scale

0.479

High

288391

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

13

High-throughput

0.479

High

346960

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.479

High

348467

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

High-throughput

0.479

High

428368

RLA2
Large ribosomal subunit protein P2

1

2

High-throughput

0.479

High

460500

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

6

High-throughput

0.479

High

461366

HS90A
Heat shock protein HSP 90-alpha

1

14

High-throughput

0.479

High

462359

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

6

High-throughput

0.479

High

468271

HS90B
Heat shock protein HSP 90-beta

1

14

High-throughput

0.479

High

482437

F16P1
Fructose-1,6-bisphosphatase 1

1

3

High-throughput

0.479

High

507162

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

12

High-throughput

0.479

High

507846

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

Small-scale

0.479

High

534939

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

536980

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

543489

VDR
Vitamin D3 receptor

1

20

Small-scale

0.479

High

550235

PABP1
Polyadenylate-binding protein 1

1

8

High-throughput

0.479

High

559311

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.479

High

566134

K1C10
Keratin, type I cytoskeletal 10

1

3

High-throughput

0.479

High

587623

DESP
Desmoplakin

1

20

High-throughput

0.479

High

600792

HSP76
Heat shock 70 kDa protein 6

1

20

High-throughput

0.479

High

608862

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

2

High-throughput

0.479

High

612605

RL7
Large ribosomal subunit protein uL30

1

3

High-throughput

0.479

High

620298

NUCL
Nucleolin

1

7

High-throughput

0.479

High

639222

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

15

Small-scale

0.479

High

655154

SFPQ
Splicing factor, proline- and glutamine-rich

1

13

High-throughput

0.479

High

664712

CCND1
G1/S-specific cyclin-D1

1

5

Small-scale

0.479

High

681340

PSA3
Proteasome subunit alpha type-3

1

8

High-throughput

0.479

High

686103

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.479

High

697498

PYR1
Multifunctional protein CAD

1

3

High-throughput

0.479

High

701134

PSB5
Proteasome subunit beta type-5

1

11

High-throughput

0.479

High

717774

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

6

High-throughput

0.479

High

718104

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

6

High-throughput

0.479

High

727766

DNJA1
DnaJ homolog subfamily A member 1

1

10

High-throughput

0.479

High

729228

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

14

High-throughput

0.479

High

754802

H2B1B
Histone H2B type 1-B

1

3

High-throughput

0.479

High

761371

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.479

High

772746

MYH9
Myosin-9

1

4

High-throughput

0.479

High

801269

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

808024

CDN1A
Cyclin-dependent kinase inhibitor 1

1

5

Small-scale

0.479

High

834425

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

840682

RS27
Small ribosomal subunit protein eS27

1

3

High-throughput

0.479

High

846243

MATR3
Matrin-3

1

4

High-throughput

0.479

High

860488

RS5
Small ribosomal subunit protein uS7

1

2

High-throughput

0.479

High

860711

RS10
Small ribosomal subunit protein eS10

1

5

High-throughput

0.479

High

862806

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

13

High-throughput

0.479

High

881152

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

881884

TCPG
T-complex protein 1 subunit gamma

1

9

High-throughput

0.479

High

903317

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

11

High-throughput

0.479

High

906501

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

5

High-throughput

0.479

High

910461

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

10

High-throughput

0.479

High

926455

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

935844

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

2

High-throughput

0.479

High

940222

SYMC
Methionine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

941398

CTBP2
C-terminal-binding protein 2

1

6

High-throughput

0.479

High

944451

GEMI4
Gem-associated protein 4

1

1

High-throughput

0.479

High

945774

EPIPL
Epiplakin

1

20

High-throughput

0.479

High

954791

PSA6
Proteasome subunit alpha type-6

1

9

High-throughput

0.479

High

958933

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.479

High

959740

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

969577

RS15A
Small ribosomal subunit protein uS8

1

1

High-throughput

0.479

High

969796

RS16
Small ribosomal subunit protein uS9

1

5

High-throughput

0.479

High

972364

RS14
Small ribosomal subunit protein uS11

1

3

High-throughput

0.479

High

972835

RS18
Small ribosomal subunit protein uS13

1

1

High-throughput

0.479

High

973399

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.479

High

975642

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.479

High

977201

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.479

High

985613

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.479

High

991292

SUMO1
Small ubiquitin-related modifier 1

1

5

Small-scale

0.479

High

993134

ACTG
Actin, cytoplasmic 2

1

15

High-throughput

0.479

High

1005842

GTF2I
General transcription factor II-I

1

1

High-throughput

0.479

High

1025978

CLH1
Clathrin heavy chain 1

1

8

High-throughput

0.479

High

1026697

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

13

High-throughput

0.479

High

1026703

EF1A2
Elongation factor 1-alpha 2

1

5

High-throughput

0.479

High

1026704

RL18
Large ribosomal subunit protein eL18

1

2

High-throughput

0.479

High

1026707

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.479

High

1026708

ILF2
Interleukin enhancer-binding factor 2

1

3

High-throughput

0.479

High

1026711

TRAF3
TNF receptor-associated factor 3

1

11

High-throughput

0.479

High

1026712

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.479

High

1026716

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

1026722

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.479

High

1026723

TNIP1
TNFAIP3-interacting protein 1

1

19

High-throughput

0.479

High

1026724

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1026725

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

1026727

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

Small-scale

0.479

High

1026728

FSCN1
Fascin

1

1

High-throughput

0.479

High

1026729

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

6

High-throughput

0.479

High

1026731

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.479

High

1026732

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1026741

CCAR2
Cell cycle and apoptosis regulator protein 2

1

3

High-throughput

0.479

High

1026751

TFG
Protein TFG

1

6

High-throughput

0.479

High

1026754

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

10

High-throughput

0.479

High

1026757

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

6

High-throughput

0.479

High

1026762

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.479

High

1026768

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.479

High

1026774

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

16

Small-scale

0.479

High

1026781

ZRAN1
Ubiquitin thioesterase ZRANB1

1

20

High-throughput

0.479

High

1026785

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

1

High-throughput

0.479

High

1026789

RUVB2
RuvB-like 2

1

10

High-throughput

0.479

High

1026790

RUVB1
RuvB-like 1

1

10

High-throughput

0.479

High

1026795

ZHX2
Zinc fingers and homeoboxes protein 2

1

4

Small-scale

0.479

High

1026753

GSLG1
Golgi apparatus protein 1

1

2

High-throughput

0.470

High

809593

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

822611

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

902450

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.458

High

969186

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.458

High

982622

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

1026744

RGS22
Regulator of G-protein signaling 22

1

0

High-throughput

0.458

High

1026767

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.458

High

1026769

GCP2
Gamma-tubulin complex component 2

1

0

High-throughput

0.458

High

273851

CNOT3
CCR4-NOT transcription complex subunit 3

1

7

High-throughput

0.445

High

330118

VENTX
Homeobox protein VENTX

1

13

High-throughput

0.445

High

395921

ESR1
Estrogen receptor

1

20

High-throughput

0.445

High

1026739

DND1
Dead end protein homolog 1

1

9

High-throughput

0.445

High

1026788

GAB2
GRB2-associated-binding protein 2

1

9

High-throughput

0.445

High

1026793

COMDA
COMM domain-containing protein 10

1

17

Small-scale

0.445

High

134279

RPOM
DNA-directed RNA polymerase, mitochondrial

1

1

High-throughput

0.437

High

238708

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

4

High-throughput

0.437

High

388514

CRP

1

1

Small-scale

0.437

High

420494

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.437

High

518777

IL8
Interleukin-8

1

15

Small-scale

0.437

High

829353

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

4

High-throughput

0.437

High

963050

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.437

High

1026706

LG3BP
Galectin-3-binding protein

1

5

High-throughput

0.437

High

1026730

ATD3B
ATPase family AAA domain-containing protein 3B

1

14

High-throughput

0.437

High

1026738

IFNL1
Interferon lambda-1

1

7

Small-scale

0.437

High

1026740

IFNL3
Interferon lambda-3

1

7

Small-scale

0.437

High

1026747

RLA0L
Putative ribosomal protein uL10-like

1

3

High-throughput

0.437

High

1026765

CCL19
C-C motif chemokine 19

1

20

Small-scale

0.437

High

1026772

RFIP5
Rab11 family-interacting protein 5

1

5

High-throughput

0.437

High

1026787

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.437

High

1026761

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

1026714

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1026742

TTC9C
Tetratricopeptide repeat protein 9C

1

4

High-throughput

0.407

High

1026777

ITM2C
Integral membrane protein 2C

1

3

High-throughput

0.407

High

1026720

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

1026700

UPAR
Urokinase plasminogen activator surface receptor

1

0

Small-scale

0.249

Low

1026758

BBC3B
Bcl-2-binding component 3, isoforms 3/4

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025