HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: ITSN1 (Q9Z0R4)
Intersectin-1 (EH and SH3 domains protein 1)
Gene: ITSN1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	16914641, 21712076, 17875942
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 1714
+	Hs
		610415 CBL_HUMAN (1-913): 0: 894: 91.05		ITSN1_HUMAN (1-1714): 0: 873: 93.96
+	Hs
		1027606 CBLB_HUMAN (23-908): 0: 799: 45.92		ITSN1_HUMAN (1-1714): 0: 873: 93.96
+	Mm
		610657 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN2_MOUSE (1-1713): 0: 708: 53.82
+	Hs
		610517 CBL_HUMAN (1-913): 0: 894: 91.05		ITSN2_HUMAN (1-1713): 0: 728: 55.54
+	Hs
		1027627 CBLB_HUMAN (23-908): 0: 799: 45.92		ITSN2_HUMAN (1-1713): 0: 728: 55.54
+	Mm
		1112081 CBLB_MOUSE (23-908): 0: 798: 46.14		ITSN2_MOUSE (1-1713): 0: 708: 53.82
+	Hs
		610397 CBL_HUMAN (1-913): 0: 894: 91.05		ARHG7_HUMAN (1040-1637): 1.34e-77: 277: 15.16
+	Hs
		506515 CBL_HUMAN (1-913): 0: 894: 91.05		BCR_HUMAN (720-1675): 2.18e-71: 265: 13.00
+	Hs
		610308 CBL_HUMAN (1-913): 0: 894: 91.05		VAV2_HUMAN (1161-1623): 3.76e-68: 250: 16.81
+	Hs
		1027604 CBLB_HUMAN (23-908): 0: 799: 45.92		ARHG7_HUMAN (1040-1637): 1.34e-77: 277: 15.16
+	Mm
		82736 B9EKI5_MOUSE (23-908): 0: 816: 47.71		VAV2_MOUSE (1161-1634): 7.02e-66: 243: 16.03
+	Hs
		855791 CBLB_HUMAN (23-908): 0: 799: 45.92		VAV2_HUMAN (1161-1623): 3.76e-68: 250: 16.81
+	Mm
		610601 CBL_MOUSE (1-913): 0: 923: 100.00		EP15R_MOUSE (430-622): 2.43e-14: 80.8: 15.54
+	Hs
		610518 CBL_HUMAN (1-913): 0: 894: 91.05		ARHGC_HUMAN (1204-1555): 6.23e-19: 96.3: 29.21
+	Hs
		610520 CBL_HUMAN (1-913): 0: 894: 91.05		EP15R_HUMAN (500-746): 3.14e-15: 83.6: 9.72
+	Mm
		1112055 CBLB_MOUSE (23-908): 0: 798: 46.14		EP15R_MOUSE (430-622): 2.43e-14: 80.8: 15.54
+	Dm
		112567 O46034_DROME (45-457): 0: 756: 70.29		M9ND00_DROME (699-1245): 8.92e-12: 72.4: 13.69
+	Hs
		257713 ANR17_HUMAN (449-911): 1.89e-09: 64.2: 8.33		ITSN2_HUMAN (1-1713): 0: 728: 55.54
+	Ce
		136804 UNC89_CAEEL (418-812): 4.65e-15: 82.7: 9.81		VAV_CAEEL (1171-1632): 2.88e-73: 268: 16.73
+	Hs
		990858 ZO1_HUMAN (435-850): 6.77e-22: 104: 14.39		SH319_HUMAN (967-1211): 1.59e-09: 65.1: 24.35