Protein: TCPA
T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha)

Gene: TCPA, TCP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 159
UniProt ID: P12612

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005832 - chaperonin-containing T-complex
GO:0005886 - plasma membrane
GO:0006457 - protein folding
GO:0016887 - ATP hydrolysis activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

553994

TCPG
T-complex protein 1 subunit gamma

6

16

Small-scale

0.925

High

553993

TCPB
T-complex protein 1 subunit beta

3

17

Small-scale

0.857

High

554035

ACT
Actin

3

19

Small-scale

0.830

High

553996

TCPZ
T-complex protein 1 subunit zeta

3

18

Small-scale

0.827

High

554037

2ABA
Protein phosphatase PP2A regulatory subunit B

3

20

High-throughput

0.770

High

553995

TCPD
T-complex protein 1 subunit delta

2

17

Small-scale

0.754

High

554005

TCPE
T-complex protein 1 subunit epsilon

2

19

Small-scale

0.754

High

554011

TCPH
T-complex protein 1 subunit eta

2

16

Small-scale

0.754

High

554021

TCPQ
T-complex protein 1 subunit theta

2

17

Small-scale

0.754

High

553981

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

2

20

High-throughput

0.726

High

553979

CAF4
CCR4-associated factor 4

2

20

High-throughput

0.705

High

553972

DCA13
Protein SOF1

2

20

High-throughput

0.694

High

553940

GBB
Guanine nucleotide-binding protein subunit beta

1

20

High-throughput

0.691

High

554074

CMR1
DNA damage-binding protein CMR1

2

20

High-throughput

0.675

High

553942

PWP1
Periodic tryptophan protein 1

1

20

High-throughput

0.618

High

554008

COPB2
Coatomer subunit beta'

1

15

High-throughput

0.618

High

554010

PFS2
Polyadenylation factor subunit 2

1

20

High-throughput

0.618

High

554064

RAD28
Radiation-sensitive protein 28

1

20

High-throughput

0.618

High

554045

PLP1
Phosducin-like protein 1

1

14

High-throughput

0.618

High

554051

CORO
Coronin-like protein

1

20

High-throughput

0.595

High

553941

PP11
Serine/threonine-protein phosphatase PP1-1

3

20

High-throughput

0.593

High

553947

SIS1
Protein SIS1

2

3

High-throughput

0.584

High

554063

PLP2
Phosducin-like protein 2

2

17

Small-scale

0.584

High

554067

RIO1
Serine/threonine-protein kinase RIO1

2

5

High-throughput

0.584

High

554023

PFD3
Prefoldin subunit 3

1

3

Small-scale

0.575

High

554034

PFD4
Prefoldin subunit 4

1

2

Small-scale

0.575

High

554048

PFD5
Prefoldin subunit 5

1

2

Small-scale

0.575

High

392114

HSP82
ATP-dependent molecular chaperone HSP82

2

13

High-throughput

0.571

High

554018

YPP1
Cargo-transport protein YPP1

2

0

High-throughput

0.563

High

553952

CDC20
APC/C activator protein CDC20

2

20

Small-scale

0.558

High

554069

WTM1
Transcriptional modulator WTM1

2

2

High-throughput

0.558

High

485994

TBA1
Tubulin alpha-1 chain

1

20

High-throughput

0.553

High

486392

TBA3
Tubulin alpha-3 chain

1

20

High-throughput

0.553

High

553980

GBLP
Small ribosomal subunit protein RACK1

1

20

Small-scale

0.553

High

553987

ARP1
Centractin

1

20

High-throughput

0.553

High

554020

MDV1
Mitochondrial division protein 1

1

20

High-throughput

0.553

High

554025

PFD6
Prefoldin subunit 6

1

0

Small-scale

0.546

High

364283

CDK1
Cyclin-dependent kinase 1

1

12

High-throughput

0.536

High

441011

KAPA
cAMP-dependent protein kinase type 1

1

20

High-throughput

0.536

High

553961

KNS1
Dual specificity protein kinase KNS1

1

10

High-throughput

0.536

High

553964

IME2
Meiosis induction protein kinase IME2/SME1

1

12

High-throughput

0.536

High

553965

RAD24
Checkpoint protein RAD24

1

2

High-throughput

0.536

High

553973

SIP2
SNF1 protein kinase subunit beta-2

1

3

High-throughput

0.536

High

554006

DSN1
Kinetochore-associated protein DSN1

2

2

High-throughput

0.533

High

554022

HGH1
Protein HGH1

2

2

Small-scale

0.533

High

553946

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

2

20

High-throughput

0.521

High

553988

RPN1
26S proteasome regulatory subunit RPN1

2

5

High-throughput

0.521

High

554036

H3
Histone H3

2

6

High-throughput

0.521

High

554009

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

0

High-throughput

0.513

High

554061

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.513

High

553960

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

20

High-throughput

0.489

High

553990

SPT8
SAGA complex subunit SPT8

1

2

High-throughput

0.489

High

554032

BRE5
UBP3-associated protein BRE5

1

6

High-throughput

0.489

High

554038

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

6

High-throughput

0.489

High

553937

HSC82
ATP-dependent molecular chaperone HSC82

1

13

High-throughput

0.479

High

553938

VATB
V-type proton ATPase subunit B

1

10

High-throughput

0.479

High

553944

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.479

High

553950

CDC48
Cell division control protein 48

1

8

High-throughput

0.479

High

553951

SPB4
ATP-dependent rRNA helicase SPB4

1

5

High-throughput

0.479

High

553958

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

553962

HOG1
Mitogen-activated protein kinase HOG1

1

13

High-throughput

0.479

High

553969

PRS6A
26S proteasome regulatory subunit 6A

1

18

High-throughput

0.479

High

554024

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.479

High

554044

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.479

High

554046

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.479

High

554071

DBP10
ATP-dependent RNA helicase DBP10

1

9

High-throughput

0.479

High

554073

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.479

High

554076

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

517858

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.457

High

553968

PRP40
Pre-mRNA-processing protein PRP40

1

1

High-throughput

0.457

High

553963

RPD3
Histone deacetylase RPD3

1

20

Small-scale

0.457

High

453330

CARA
Carbamoyl phosphate synthase arginine-specific small chain

1

1

High-throughput

0.445

High

460302

SYV
Valine--tRNA ligase, mitochondrial

1

2

High-throughput

0.445

High

522874

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

543618

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

553939

VATA
V-type proton ATPase catalytic subunit A

1

16

High-throughput

0.445

High

553975

DHR2
Probable ATP-dependent RNA helicase DHR2

1

1

High-throughput

0.445

High

554000

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

554002

RIO2
Serine/threonine-protein kinase RIO2

1

5

High-throughput

0.445

High

554003

ATAD2
ATPase histone chaperone YTA7

1

12

High-throughput

0.445

High

554029

INO80
Chromatin-remodeling ATPase INO80

1

3

High-throughput

0.445

High

554047

KU80
ATP-dependent DNA helicase II subunit 2

1

3

High-throughput

0.445

High

554054

SUB2
ATP-dependent RNA helicase SUB2

1

10

High-throughput

0.445

High

554072

GDIR
Rho GDP-dissociation inhibitor

1

1

High-throughput

0.445

High

434759

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.437

High

435724

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

553936

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

553943

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

6

High-throughput

0.437

High

553948

SGF29
SAGA complex subunit SGF29

1

1

Small-scale

0.437

High

553949

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

553957

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

553959

EF2
Elongation factor 2

1

6

High-throughput

0.437

High

553966

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

553967

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

553976

CENPA
Histone H3-like centromeric protein CSE4

1

6

High-throughput

0.437

High

553983

MAP2
Methionine aminopeptidase 2

1

5

High-throughput

0.437

High

553984

ATG8
Autophagy-related protein 8

1

16

High-throughput

0.437

High

553989

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

17

Small-scale

0.437

High

553997

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

553999

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.437

High

554001

VID27
Vacuolar import and degradation protein 27

1

2

High-throughput

0.437

High

554012

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

554014

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

8

High-throughput

0.437

High

554030

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

554039

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

554041

BUL2
Ubiquitin ligase-binding protein BUL2

1

3

Small-scale

0.437

High

554043

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.437

High

554049

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.437

High

554057

SGO1
Shugoshin

1

2

High-throughput

0.437

High

554058

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.437

High

554059

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

553991

ATU2
Copper-transporting ATPase

1

0

High-throughput

0.426

High

554027

ACS2
Acetyl-coenzyme A synthetase 2

1

0

High-throughput

0.426

High

554052

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

High-throughput

0.426

High

381827

H4
Histone H4

1

1

High-throughput

0.407

High

394164

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

430757

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

4

High-throughput

0.407

High

438371

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

3

High-throughput

0.407

High

458992

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

8

High-throughput

0.407

High

553956

HIBCH
Small ribosomal subunit protein mS47

1

2

High-throughput

0.407

High

553970

MED9
Mediator of RNA polymerase II transcription subunit 9

1

1

High-throughput

0.407

High

554007

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.407

High

554015

SAD1
Pre-mRNA-splicing factor SAD1

1

6

High-throughput

0.407

High

554016

LSB3
LAS seventeen-binding protein 3

1

4

High-throughput

0.407

High

554028

HOS2
Probable histone deacetylase HOS2

1

20

High-throughput

0.407

High

554031

RT102
Regulator of Ty1 transposition protein 102

1

1

High-throughput

0.407

High

554033

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.407

High

554053

CDC73
Cell division control protein 73

1

4

High-throughput

0.407

High

554055

RLP24
Ribosome biogenesis protein RLP24

1

1

High-throughput

0.407

High

554060

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.407

High

554070

RPN6
26S proteasome regulatory subunit RPN6

1

1

High-throughput

0.407

High

554075

SET6
Potential protein lysine methyltransferase SET6

1

2

High-throughput

0.407

High

553992

POP2
Poly(A) ribonuclease POP2

2

0

High-throughput

0.307

High

554056

YL030
Putative uncharacterized protein YLR030W

1

0

High-throughput

0.282

High

553955

YJU2
Splicing factor YJU2

1

0

High-throughput

0.279

Low

553982

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.279

Low

554040

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.265

Low

554065

HUA2
Protein HUA2

1

0

High-throughput

0.265

Low

553945

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.261

Low

554013

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.261

Low

553974

CENPC
Inner kinetochore subunit MIF2

1

0

High-throughput

0.251

Low

553978

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

554026

NUP84
Nucleoporin NUP84

1

0

High-throughput

0.249

Low

554077

HPH1
Protein HPH1

1

0

High-throughput

0.238

Low

553953

RFA3
Replication factor A protein 3

1

0

High-throughput

0.232

Low

553954

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.232

Low

553971

MFT1
THO complex subunit MFT1

1

0

High-throughput

0.232

Low

553977

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.232

Low

553985

CS111
F-box protein COS111

1

0

High-throughput

0.232

Low

553986

DPH7
Diphthine methyltransferase

1

0

High-throughput

0.232

Low

553998

NOC2
Nucleolar complex protein 2

1

0

High-throughput

0.232

Low

554004

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.232

Low

554017

STU2
Protein STU2

1

0

High-throughput

0.232

Low

554019

YJS1
UPF0508 protein YJL181W

1

0

High-throughput

0.232

Low

554042

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.232

Low

554050

LSM6
LSM complex subunit LSM6

1

0

High-throughput

0.232

Low

554062

DDC1
DNA damage checkpoint protein 1

1

0

High-throughput

0.232

Low

554066

RFM1
Repression factor of MSEs protein 1

1

0

High-throughput

0.232

Low

554068

DAD1
DASH complex subunit DAD1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025