HitPredict

Interactor 1: NR4A1 (P22736)
Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)
Gene: NR4A1

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12082103
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 598 Hs			1 1424
+	Hs
		1025276 NR1H3_HUMAN (178-591): 7.99e-114: 348: 29.29		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		992458 PPARA_HUMAN (212-595): 3.12e-111: 342: 23.62		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		500511 THB_HUMAN (236-594): 2.38e-110: 340: 27.32		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		587212 RXRA_HUMAN (120-594): 4e-109: 337: 26.36		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		611451 NR4A1_HUMAN (1-598): 8.52e-140: 420: 100.00		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		611445 NR4A1_HUMAN (1-598): 8.52e-140: 420: 100.00		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		1085620 NR4A3_HUMAN (1-598): 3.91e-104: 329: 44.18		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		587195 RXRA_HUMAN (120-594): 4e-109: 337: 26.36		NPAS2_HUMAN (19-807): 7.51e-111: 372: 16.20
+	Hs
		611447 NR4A1_HUMAN (1-598): 8.52e-140: 420: 100.00		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		992420 PPARA_HUMAN (212-595): 3.12e-111: 342: 23.62		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		500487 THB_HUMAN (236-594): 2.38e-110: 340: 27.32		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		587173 RXRA_HUMAN (120-594): 4e-109: 337: 26.36		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		126103 RXRA_HUMAN (120-594): 4e-109: 337: 26.36		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		795598 NR4A2_HUMAN (1-598): 1.06e-112: 350: 51.05		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		1025256 NR1H3_HUMAN (178-591): 7.99e-114: 348: 29.29		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		992422 PPARA_HUMAN (212-595): 3.12e-111: 342: 23.62		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		500491 THB_HUMAN (236-594): 2.38e-110: 340: 27.32		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		181498 RXRA_HUMAN (120-594): 4e-109: 337: 26.36		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		587177 RXRA_HUMAN (120-594): 4e-109: 337: 26.36		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		437642 MCR_HUMAN (2-597): 2.28e-101: 331: 19.57		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53