HitPredict - High confidence protein-protein interactions

Interactor 1: EST1 (P23141)
Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)
Gene: CES1

Interactor 2: EST1 (P23141)
Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)
Gene: CES1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12679808
Identification Methods	x-ray crystallography
Interaction Type	association

Property	Details
Interacting Pfam domains	COesterase~COesterase
Common GO terms	GO:0004771 - sterol esterase activity GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005788 - endoplasmic reticulum lumen GO:0005811 - lipid droplet and 20 others more... GO:0005829 - cytosol GO:0006695 - cholesterol biosynthetic process GO:0008203 - cholesterol metabolic process GO:0009636 - response to toxic substance GO:0010875 - positive regulation of cholesterol efflux GO:0010887 - negative regulation of cholesterol storage GO:0016042 - lipid catabolic process GO:0030855 - epithelial cell differentiation GO:0042632 - cholesterol homeostasis GO:0043691 - reverse cholesterol transport GO:0047374 - methylumbelliferyl-acetate deacetylase activity GO:0051791 - medium-chain fatty acid metabolic process GO:0052689 - carboxylic ester hydrolase activity GO:0070857 - regulation of bile acid biosynthetic process GO:0071397 - cellular response to cholesterol GO:0071404 - cellular response to low-density lipoprotein particle stimulus GO:0090122 - cholesterol ester hydrolysis involved in cholesterol transport GO:0090205 - positive regulation of cholesterol metabolic process GO:0106435 - carboxylesterase activity GO:0120188 - regulation of bile acid secretion
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1	567
Hs

1	567

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Last updated: 15 Jul 2024