Protein: KS6A2
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)

Gene: KS6A2, RPS6KA2
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q15349

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001556 - oocyte maturation
GO:0002035 - brain renin-angiotensin system
GO:0004674 - protein serine/threonine kinase activity
GO:0004711 - ribosomal protein S6 kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703602

MK01
Mitogen-activated protein kinase 1

11

20

Small-scale

0.979

High

691749

MK03
Mitogen-activated protein kinase 3

6

20

Small-scale

0.949

High

1146416

KS6A1
Ribosomal protein S6 kinase alpha-1

5

15

High-throughput

0.925

High

995051

CSK2B
Casein kinase II subunit beta

4

8

High-throughput

0.897

High

908114

KS6A3
Ribosomal protein S6 kinase alpha-3

4

15

High-throughput

0.892

High

1122234

SCRIB
Protein scribble homolog

3

7

Small-scale

0.883

High

1087396

GRSF1
G-rich sequence factor 1

3

12

High-throughput

0.861

High

440568

FYN
Tyrosine-protein kinase Fyn

2

20

High-throughput

0.811

High

641178

FGFR2
Fibroblast growth factor receptor 2

2

20

High-throughput

0.811

High

1085072

KIF1A
Kinesin-like protein KIF1A

2

3

High-throughput

0.789

High

1146415

KS6A2
Ribosomal protein S6 kinase alpha-2

2

15

Small-scale

0.768

High

1146499

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

4

High-throughput

0.692

High

184639

MK13
Mitogen-activated protein kinase 13

1

20

High-throughput

0.691

High

541502

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.691

High

837225

ACTY
Beta-centractin

1

10

High-throughput

0.691

High

1146419

CDC37
Hsp90 co-chaperone Cdc37

1

15

High-throughput

0.691

High

1146421

AMHR2
Anti-Muellerian hormone type-2 receptor

1

3

High-throughput

0.691

High

1146472

STRAB
STE20-related kinase adapter protein beta

1

17

High-throughput

0.691

High

1146486

ARP10
Actin-related protein 10

1

10

High-throughput

0.691

High

167273

KLF11
Krueppel-like factor 11

1

5

High-throughput

0.665

High

488224

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

3

High-throughput

0.628

High

1146451

TRI11
E3 ubiquitin-protein ligase TRIM11

2

3

High-throughput

0.628

High

161994

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

17

High-throughput

0.618

High

241748

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.618

High

331757

MTMR5
Myotubularin-related protein 5

1

2

High-throughput

0.618

High

354703

PAK4
Serine/threonine-protein kinase PAK 4

1

19

High-throughput

0.618

High

461502

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

463100

YES
Tyrosine-protein kinase Yes

1

20

High-throughput

0.618

High

468396

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

578486

BRAF
Serine/threonine-protein kinase B-raf

1

15

Small-scale

0.618

High

603275

KPCA
Protein kinase C alpha type

1

17

Small-scale

0.618

High

625399

CSK22
Casein kinase II subunit alpha'

1

14

High-throughput

0.618

High

710254

EPHA2
Ephrin type-A receptor 2

1

13

High-throughput

0.618

High

849178

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

1004062

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.618

High

1034238

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

1034994

KPCE
Protein kinase C epsilon type

1

19

Small-scale

0.618

High

1047551

NOTC2
Neurogenic locus notch homolog protein 2

1

2

High-throughput

0.618

High

1146428

BCOR
BCL-6 corepressor

1

4

High-throughput

0.618

High

1146429

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1146431

LIPB1
Liprin-beta-1

1

9

High-throughput

0.618

High

1146446

FERM2
Fermitin family homolog 2

1

1

High-throughput

0.618

High

1146480

PKHA5
Pleckstrin homology domain-containing family A member 5

1

16

High-throughput

0.618

High

1146487

IBTK
Inhibitor of Bruton tyrosine kinase

1

5

High-throughput

0.618

High

1146488

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

18

High-throughput

0.618

High

1146494

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

5

High-throughput

0.618

High

1146500

MRCKB
Serine/threonine-protein kinase MRCK beta

1

13

High-throughput

0.618

High

334779

IPO7
Importin-7

2

10

High-throughput

0.611

High

1146490

ZMYM5
Zinc finger MYM-type protein 5

2

1

High-throughput

0.611

High

1118865

BYST
Bystin

1

0

High-throughput

0.586

High

1146426

IIGP5
Interferon-inducible GTPase 5

2

2

High-throughput

0.574

High

1146433

MISP
Mitotic interactor and substrate of PLK1

2

2

High-throughput

0.574

High

982449

RS15
Small ribosomal subunit protein uS19

2

1

High-throughput

0.571

High

845648

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.553

High

1146442

NECT2
Nectin-2

1

2

High-throughput

0.553

High

1146455

KIRR1
Kin of IRRE-like protein 1

1

2

High-throughput

0.553

High

1146468

EFHD1
EF-hand domain-containing protein D1

1

2

High-throughput

0.553

High

880310

RL34
Large ribosomal subunit protein eL34

2

0

High-throughput

0.547

High

298172

DCTN3
Dynactin subunit 3

1

1

High-throughput

0.536

High

916265

TXTP
Tricarboxylate transport protein, mitochondrial

1

3

High-throughput

0.536

High

1127560

FAT1
Protocadherin Fat 1

1

1

High-throughput

0.536

High

1143998

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1146430

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

7

High-throughput

0.536

High

1146441

PDC6I
Programmed cell death 6-interacting protein

1

12

High-throughput

0.536

High

1146445

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

High-throughput

0.536

High

1146447

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

1146461

NEB2
Neurabin-2

1

20

High-throughput

0.536

High

1146467

DCTN5
Dynactin subunit 5

1

1

High-throughput

0.536

High

1146474

KLH25
Kelch-like protein 25

1

5

High-throughput

0.536

High

422137

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.515

High

133355

DCTN6
Dynactin subunit 6

1

0

High-throughput

0.513

High

593668

BGAL
Beta-galactosidase

1

0

High-throughput

0.513

High

370676

FOS
Protein c-Fos

1

6

Small-scale

0.501

High

429930

JUN
Transcription factor Jun

1

12

Small-scale

0.501

High

1091500

DLG1
Disks large homolog 1

1

9

High-throughput

0.501

High

1022390

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.489

High

1146425

RL7L
Ribosomal protein uL30-like

1

2

High-throughput

0.489

High

1146439

SHRM3
Protein Shroom3

1

5

High-throughput

0.489

High

1146452

I17RA
Interleukin-17 receptor A

1

3

High-throughput

0.489

High

1146470

CDHR2
Cadherin-related family member 2

1

3

High-throughput

0.489

High

1146496

ADA18
Disintegrin and metalloproteinase domain-containing protein 18

1

1

High-throughput

0.489

High

413881

P53
Cellular tumor antigen p53

1

5

Small-scale

0.481

High

1125340

FLNC
Filamin-C

1

3

High-throughput

0.481

High

124053

SNP23
Synaptosomal-associated protein 23

1

1

High-throughput

0.479

High

125742

STXB3
Syntaxin-binding protein 3

1

2

High-throughput

0.479

High

136390

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.479

High

138692

IMA4
Importin subunit alpha-4

1

5

High-throughput

0.479

High

159351

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

13

High-throughput

0.479

High

160508

IRS4
Insulin receptor substrate 4

1

4

High-throughput

0.479

High

187721

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

1

High-throughput

0.479

High

189167

IPO8
Importin-8

1

8

High-throughput

0.479

High

230028

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

2

High-throughput

0.479

High

251214

RNBP6
Ran-binding protein 6

1

5

High-throughput

0.479

High

254144

CTND1
Catenin delta-1

1

9

High-throughput

0.479

High

273668

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

6

High-throughput

0.479

High

317845

LTN1
E3 ubiquitin-protein ligase listerin

1

4

High-throughput

0.479

High

431818

ITB1
Integrin beta-1

1

3

High-throughput

0.479

High

467495

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.479

High

648165

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.479

High

699759

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

High-throughput

0.479

High

715595

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

730602

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

878316

MRP
MARCKS-related protein

1

1

High-throughput

0.479

High

896242

PEX5
Peroxisomal targeting signal 1 receptor

1

3

High-throughput

0.479

High

936756

NP1L1
Nucleosome assembly protein 1-like 1

1

3

High-throughput

0.479

High

970543

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

971553

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.479

High

1023936

EM55
55 kDa erythrocyte membrane protein

1

8

High-throughput

0.479

High

1041077

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

1108545

TBB3
Tubulin beta-3 chain

1

17

High-throughput

0.479

High

1112360

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

1

3

High-throughput

0.479

High

1120725

DSG2
Desmoglein-2

1

5

High-throughput

0.479

High

1131661

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

3

High-throughput

0.479

High

1146420

OCLN
Occludin

1

2

High-throughput

0.479

High

1146423

MPP7
MAGUK p55 subfamily member 7

1

8

High-throughput

0.479

High

1146424

STEA3
Metalloreductase STEAP3

1

2

High-throughput

0.479

High

1146427

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.479

High

1146432

CNDG2
Condensin-2 complex subunit G2

1

1

High-throughput

0.479

High

1146434

ABI1
Abl interactor 1

1

13

High-throughput

0.479

High

1146435

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

High-throughput

0.479

High

1146436

DOCK4
Dedicator of cytokinesis protein 4

1

6

High-throughput

0.479

High

1146440

FRS2
Fibroblast growth factor receptor substrate 2

1

2

High-throughput

0.479

High

1146443

CBP
CREB-binding protein

1

14

Small-scale

0.479

High

1146444

RENT1
Regulator of nonsense transcripts 1

1

2

High-throughput

0.479

High

1146450

AP2M1
AP-2 complex subunit mu

1

7

High-throughput

0.479

High

1146453

LTV1
Protein LTV1 homolog

1

1

High-throughput

0.479

High

1146454

SAHH3
Adenosylhomocysteinase 3

1

2

High-throughput

0.479

High

1146458

IPO9
Importin-9

1

8

High-throughput

0.479

High

1146459

S38A2
Sodium-coupled neutral amino acid symporter 2

1

1

High-throughput

0.479

High

1146462

PKP4
Plakophilin-4

1

8

High-throughput

0.479

High

1146463

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

7

High-throughput

0.479

High

1146464

CDCA3
Cell division cycle-associated protein 3

1

1

High-throughput

0.479

High

1146465

NP1L4
Nucleosome assembly protein 1-like 4

1

4

High-throughput

0.479

High

1146471

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.479

High

1146477

E41LB
Band 4.1-like protein 4B

1

8

High-throughput

0.479

High

1146479

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

3

High-throughput

0.479

High

1146481

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

1146482

WDR6
tRNA

1

12

High-throughput

0.479

High

1146484

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.479

High

1146485

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.479

High

1146489

ADDG
Gamma-adducin

1

2

High-throughput

0.479

High

1146491

DDX41
Probable ATP-dependent RNA helicase DDX41

1

8

High-throughput

0.479

High

1146495

NISCH
Nischarin

1

5

High-throughput

0.479

High

1146498

TELO2
Telomere length regulation protein TEL2 homolog

1

1

High-throughput

0.479

High

192252

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

351109

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.458

High

571147

CD99
CD99 antigen

1

0

High-throughput

0.458

High

1031789

LAT1
Large neutral amino acids transporter small subunit 1

1

0

High-throughput

0.458

High

1122006

EFR3A
Protein EFR3 homolog A

1

0

High-throughput

0.458

High

1146418

VAMP3
Vesicle-associated membrane protein 3

1

0

High-throughput

0.458

High

1146422

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.458

High

1146437

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.458

High

1146449

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.458

High

1146456

ELMO2
Engulfment and cell motility protein 2

1

0

High-throughput

0.458

High

1146469

THUM3
tRNA

1

0

High-throughput

0.458

High

1146473

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

1146478

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

0

High-throughput

0.458

High

1146483

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

0

High-throughput

0.458

High

1146497

WAC2C
WASH complex subunit 2C

1

0

High-throughput

0.458

High

978953

RS6
Small ribosomal subunit protein eS6

1

10

Small-scale

0.445

High

1130264

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.445

High

81713

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

7

High-throughput

0.437

High

105973

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

469085

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.437

High

869594

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

2

High-throughput

0.437

High

933407

S12A2
Solute carrier family 12 member 2

1

1

High-throughput

0.437

High

1124812

FLOT2
Flotillin-2

1

6

High-throughput

0.437

High

1146438

VANG1
Vang-like protein 1

1

3

High-throughput

0.437

High

1146460

PANX1
Pannexin-1

1

1

High-throughput

0.437

High

1146466

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.437

High

1146475

S38A1
Sodium-coupled neutral amino acid symporter 1

1

1

High-throughput

0.437

High

1146476

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

2

High-throughput

0.437

High

1146493

VANG2
Vang-like protein 2

1

3

High-throughput

0.437

High

1146501

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

2

High-throughput

0.437

High

1146502

S4A7
Sodium bicarbonate cotransporter 3

1

2

High-throughput

0.437

High

516898

ECE2
Endothelin-converting enzyme 2

1

3

High-throughput

0.407

High

299983

CBPD
Carboxypeptidase D

1

0

High-throughput

0.249

Low

338619

AGRL2
Adhesion G protein-coupled receptor L2

1

0

High-throughput

0.249

Low

931368

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.249

Low

1146417

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.249

Low

1146448

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.249

Low

1146457

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.249

Low

1146492

S39AA
Zinc transporter ZIP10

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025