HitPredict

Interactor 1: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Interactor 2: NCBP2 (P52298)
Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)
Gene: NCBP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	32960270
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	NOPS~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0000380 - alternative mRNA splicing, via spliceosome GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 2 others more... GO:0005829 - cytosol GO:0008380 - RNA splicing
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 707 Hs			1 156
+	Hs
		853881 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		NCBP2_HUMAN (1-156): 2.27e-48: 154: 100.00
+	Hs
		516425 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		NCBP2_HUMAN (1-156): 2.27e-48: 154: 100.00
+	Hs
		853899 NONO_HUMAN (265-707): 1.49e-70: 239: 56.98		NCBP2_HUMAN (1-156): 2.27e-48: 154: 100.00
+	Ce
		71809 B3GWA1_CAEEL (289-558): 6.93e-77: 259: 48.52		O45577_CAEEL (27-148): 4.43e-36: 128: 28.23
+	Hs
		516495 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		PABP1_HUMAN (4-156): 7.45e-28: 109: 18.41
+	Hs
		1020249 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		ELAV2_HUMAN (33-122): 1.29e-25: 101: 21.11
+	Hs
		1031344 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		ELAV1_HUMAN (7-123): 1.27e-24: 98.4: 18.49
+	Sc
		376958 PABP_YEAST (293-687): 2.32e-69: 239: 15.84		NCBP2_YEAST (10-150): 3.97e-39: 132: 52.48
+	Hs
		1031490 PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38		PUF60_HUMAN (30-113): 1.88e-17: 80.1: 30.95
+	Hs
		613470 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		ELAV1_HUMAN (7-123): 1.27e-24: 98.4: 18.49
+	Hs
		516339 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PABP1_HUMAN (4-156): 7.45e-28: 109: 18.41
+	Hs
		516689 PABP3_HUMAN (287-700): 9.1e-69: 239: 16.88		PABP1_HUMAN (4-156): 7.45e-28: 109: 18.41
+	Hs
		516484 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		ELAV2_HUMAN (33-122): 1.29e-25: 101: 21.11
+	Hs
		1069687 NONO_HUMAN (265-707): 1.49e-70: 239: 56.98		ELAV1_HUMAN (7-123): 1.27e-24: 98.4: 18.49
+	Mm
		665745 PABP1_MOUSE (287-700): 2.49e-70: 243: 16.67		TIA1_MOUSE (1-140): 7e-21: 89.1: 19.58
+	Hs
		516471 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		TIAR_HUMAN (1-155): 1e-19: 85.7: 16.46
+	Hs
		516730 PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46		PUF60_HUMAN (30-113): 1.88e-17: 80.1: 30.95
+	Sc
		376645 PABP_YEAST (293-687): 2.32e-69: 239: 15.84		RNA15_YEAST (38-112): 6.54e-19: 82.8: 29.33
+	Hs
		613467 SFPQ_HUMAN (1-707): 4.51e-74: 255: 100.00		SF3B4_HUMAN (30-116): 8.18e-11: 60.8: 23.86