HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: EPN4 (Q14677)
Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)
Gene: CLINT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 939 Hs			1 625
+	Hs
		321545 AP2A1_HUMAN (1-939): 0: 832: 78.47		EPN4_HUMAN (1-625): 2.12e-141: 426: 100.00
+	Rn
		291387 AP2A2_RAT (1-939): 0: 889: 97.02		EPN1_RAT (8-529): 1.01e-68: 235: 24.63
+	Rn
		291395 Q66HM2_RAT (1-939): 0: 886: 96.28		EPN1_RAT (8-529): 1.01e-68: 235: 24.63
+	Hs
		302230 AP2A2_HUMAN (1-939): 0: 884: 100.00		EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55
+	Rn
		88757 D3ZUY8_RAT (1-939): 0: 836: 81.17		EPN1_RAT (8-529): 1.01e-68: 235: 24.63
+	Hs
		321680 AP2A1_HUMAN (1-939): 0: 832: 78.47		EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55
+	Dm
		954828 AP2A_DROME (3-939): 0: 819: 69.50		Q7KU90_DROME (6-624): 1.54e-65: 232: 21.07
+	Hs
		212629 AP1G1_HUMAN (1-811): 0: 616: 25.12		EPN4_HUMAN (1-625): 2.12e-141: 426: 100.00
+	Hs
		925867 AP2B1_HUMAN (36-933): 0: 607: 16.62		EPN4_HUMAN (1-625): 2.12e-141: 426: 100.00
+	Hs
		203194 AP2A1_HUMAN (1-939): 0: 832: 78.47		SYNJ1_HUMAN (120-617): 7.92e-35: 143: 10.29
+	Rn
		1144064 Q66HM2_RAT (1-939): 0: 886: 96.28		SYNJ1_RAT (314-625): 4.54e-10: 65: 10.35
+	At
		1228257 AP2A1_ARATH (8-939): 0: 711: 37.23		EPN1_ARATH (7-421): 1.05e-66: 229: 21.81
+	At
		1147101 AP2A1_ARATH (8-939): 0: 711: 37.23		EPN2_ARATH (7-612): 4.91e-48: 182: 17.53
+	Rn
		923862 AP2B1_RAT (36-933): 0: 607: 16.62		EPN2_RAT (8-556): 7.08e-74: 249: 19.17
+	Rn
		291389 AP2B1_RAT (36-933): 0: 607: 16.62		EPN1_RAT (8-529): 1.01e-68: 235: 24.63
+	Hs
		926065 AP2B1_HUMAN (36-933): 0: 607: 16.62		EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55
+	Sc
		743416 AP2A_YEAST (10-937): 0: 606: 25.44		ENT1_YEAST (8-250): 7.46e-68: 229: 27.98
+	Hs
		307524 AP2B1_HUMAN (36-933): 0: 607: 16.62		EPN2_HUMAN (8-595): 6.55e-52: 191: 20.40
+	Hs
		203219 AP2B1_HUMAN (36-933): 0: 607: 16.62		SYNJ1_HUMAN (120-617): 7.92e-35: 143: 10.29
+	Hs
		203223 AP1B1_HUMAN (36-934): 0: 606: 17.35		SYNJ1_HUMAN (120-617): 7.92e-35: 143: 10.29