HitPredict

Interactor 1: S10A1 (P23297)
Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
Gene: S100A1

Interactor 2: S100Z (Q8WXG8)
Protein S100-Z (S100 calcium-binding protein Z)
Gene: S100Z

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EF-hand_1~S_100, S_100~S_100
Common GO terms	GO:0005509 - calcium ion binding GO:0042803 - protein homodimerization activity GO:0048306 - calcium-dependent protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 94 Hs			1 99
+	Hs
		1135040 Q5T7Y6_HUMAN (1-94): 8.82e-42: 135: 100.00		Q5T7Y6_HUMAN (1-94): 1.52e-41: 134: 57.45
+	Hs
		638981 Q5T7Y6_HUMAN (1-94): 8.82e-42: 135: 100.00		S100P_HUMAN (3-93): 1.58e-34: 115: 51.65
+	Hs
		615200 S10A1_HUMAN (1-94): 9.45e-38: 123: 100.00		S10A1_HUMAN (1-94): 6.61e-38: 124: 57.45
+	Hs
		685154 S10AB_HUMAN (2-92): 6.83e-36: 119: 41.76		S10AB_HUMAN (2-99): 8.78e-39: 126: 31.63
+	Mm
		881595 S10A1_MOUSE (1-94): 5.4e-37: 121: 92.55		S10A1_MOUSE (1-94): 3.95e-37: 121: 56.38
+	Hs
		380790 Q5T7Y6_HUMAN (1-94): 8.82e-42: 135: 100.00		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		615201 S10A1_HUMAN (1-94): 9.45e-38: 123: 100.00		S100P_HUMAN (3-93): 1.58e-34: 115: 51.65
+	Hs
		615203 S10A1_HUMAN (1-94): 9.45e-38: 123: 100.00		S10A4_HUMAN (1-90): 7.21e-33: 111: 46.67
+	Mm
		421246 S10A1_MOUSE (1-94): 5.4e-37: 121: 92.55		S10A4_MOUSE (1-90): 8.4e-33: 111: 45.56
+	Hs
		615204 S10A1_HUMAN (1-94): 9.45e-38: 123: 100.00		S10A2_HUMAN (1-92): 2.41e-32: 109: 42.39
+	Hs
		893783 S10AA_HUMAN (1-91): 5.26e-33: 111: 48.35		S10AA_HUMAN (1-99): 2.16e-36: 120: 44.44
+	Hs
		893821 S100Z_HUMAN (1-93): 4.63e-33: 111: 58.07		S10AA_HUMAN (1-99): 2.16e-36: 120: 44.44
+	Hs
		615206 S10A1_HUMAN (1-94): 9.45e-38: 123: 100.00		S10A3_HUMAN (1-90): 6.14e-31: 106: 37.78
+	Hs
		380736 S10A1_HUMAN (1-94): 9.45e-38: 123: 100.00		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		639031 S100Z_HUMAN (1-93): 4.63e-33: 111: 58.07		S100P_HUMAN (3-93): 1.58e-34: 115: 51.65
+	Hs
		1125327 HORN_HUMAN (1-88): 6.3e-32: 118: 35.23		FILA2_HUMAN (3-93): 5.07e-28: 107: 37.36
+	Hs
		380745 S10AB_HUMAN (2-92): 6.83e-36: 119: 41.76		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		707361 S10AA_HUMAN (1-91): 5.26e-33: 111: 48.35		S10A3_HUMAN (1-90): 6.14e-31: 106: 37.78
+	Hs
		707385 S100Z_HUMAN (1-93): 4.63e-33: 111: 58.07		S10A3_HUMAN (1-90): 6.14e-31: 106: 37.78
+	Hs
		380823 S100Z_HUMAN (1-93): 4.63e-33: 111: 58.07		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06