HitPredict

Interactor 1: MYF6 (P23409)
Myogenic factor 6 (Myf-6) (Class C basic helix-loop-helix protein 4) (bHLHc4) (Muscle-specific regulatory factor 4)
Gene: MYF6

Interactor 2: ID4 (P47928)
DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4)
Gene: ID4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046983 - protein dimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 161
+	Hs
		546072 MYOG_HUMAN (3-240): 4.89e-48: 159: 42.98		ID4_HUMAN (1-161): 1.67e-63: 194: 100.00
+	Hs
		526742 MYF5_HUMAN (2-237): 1.07e-55: 180: 38.66		ID1_HUMAN (12-161): 1.12e-51: 163: 37.42
+	Hs
		546071 MYOG_HUMAN (3-240): 4.89e-48: 159: 42.98		ID1_HUMAN (12-161): 1.12e-51: 163: 37.42
+	Hs
		526743 MYF5_HUMAN (2-237): 1.07e-55: 180: 38.66		ID2_HUMAN (1-148): 2.51e-41: 136: 43.24
+	Mm
		485951 MYOD1_MOUSE (5-230): 4.18e-40: 142: 36.48		Q6GTZ3_MOUSE (35-161): 2e-51: 162: 39.39
+	Hs
		545945 MYOD1_HUMAN (5-236): 8.2e-39: 138: 35.60		ID1_HUMAN (12-161): 1.12e-51: 163: 37.42
+	Hs
		526744 MYF5_HUMAN (2-237): 1.07e-55: 180: 38.66		ID3_HUMAN (1-135): 2.13e-33: 116: 44.44
+	Hs
		568188 TAL1_HUMAN (45-219): 7.56e-25: 101: 18.13		ID4_HUMAN (1-161): 1.67e-63: 194: 100.00
+	Hs
		814909 FIGLA_HUMAN (39-223): 1.18e-25: 101: 18.65		ID4_HUMAN (1-161): 1.67e-63: 194: 100.00
+	Hs
		524549 LYL1_HUMAN (22-210): 8.44e-25: 100: 18.97		ID4_HUMAN (1-161): 1.67e-63: 194: 100.00
+	Hs
		814916 NGN3_HUMAN (32-219): 3.59e-25: 100: 19.58		ID4_HUMAN (1-161): 1.67e-63: 194: 100.00
+	Mm
		485939 MYOD1_MOUSE (5-230): 4.18e-40: 142: 36.48		ID2_MOUSE (1-148): 1.17e-41: 137: 42.57
+	Hs
		545958 MYOD1_HUMAN (5-236): 8.2e-39: 138: 35.60		ID2_HUMAN (1-148): 2.51e-41: 136: 43.24
+	Hs
		524547 LYL1_HUMAN (22-210): 8.44e-25: 100: 18.97		ID1_HUMAN (12-161): 1.12e-51: 163: 37.42
+	Mm
		485938 MYOD1_MOUSE (5-230): 4.18e-40: 142: 36.48		ID3_MOUSE (1-135): 2.97e-32: 113: 42.96
+	Hs
		545959 MYOD1_HUMAN (5-236): 8.2e-39: 138: 35.60		ID3_HUMAN (1-135): 2.13e-33: 116: 44.44
+	Mm
		589139 TAL1_MOUSE (45-219): 3.69e-25: 102: 18.89		ID1_MOUSE (35-149): 7.26e-47: 152: 40.00
+	Hs
		524557 LYL1_HUMAN (22-210): 8.44e-25: 100: 18.97		ID3_HUMAN (1-135): 2.13e-33: 116: 44.44
+	Dm
		509355 DA_DROME (21-225): 2.07e-30: 120: 15.35		EMC_DROME (67-115): 6.12e-18: 78.5: 55.10
+	Dm
		485922 AST4_DROME (2-156): 1.04e-24: 101: 19.16		EMC_DROME (67-115): 6.12e-18: 78.5: 55.10