HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: LPAR6 (P43657)
Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) (RB intron encoded G-protein coupled receptor)
Gene: LPAR6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 344
+	Hs
		616743 JAK1_HUMAN (1-1154): 0: 1035: 100.00		AGTR1_HUMAN (5-340): 4.07e-72: 229: 25.22
+	Hs
		616748 JAK1_HUMAN (1-1154): 0: 1035: 100.00		APJ_HUMAN (5-334): 5.38e-69: 222: 23.60
+	Hs
		616777 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CXCR4_HUMAN (7-311): 7.44e-68: 218: 27.60
+	Hs
		126567 JAK1_HUMAN (1-1154): 0: 1035: 100.00		P2Y10_HUMAN (12-312): 2.35e-45: 159: 31.46
+	Hs
		238386 JAK2_HUMAN (33-1153): 0: 799: 42.14		CCR5_HUMAN (19-302): 3.57e-84: 260: 27.47
+	Hs
		238366 JAK2_HUMAN (33-1153): 0: 799: 42.14		AGTR1_HUMAN (5-340): 4.07e-72: 229: 25.22
+	Hs
		238391 JAK2_HUMAN (33-1153): 0: 799: 42.14		CXCR4_HUMAN (7-311): 7.44e-68: 218: 27.60
+	Rn
		626617 JAK2_RAT (33-1153): 0: 782: 41.54		AGTRA_RAT (5-344): 1.79e-72: 230: 25.22
+	Hs
		238359 JAK2_HUMAN (33-1153): 0: 799: 42.14		PTAFR_HUMAN (5-312): 8.64e-41: 147: 28.80
+	Hs
		522832 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		P2RY2_HUMAN (9-297): 1.06e-83: 259: 33.56
+	Rn
		706745 SRC_RAT (868-1151): 1.4e-97: 322: 30.88		OPRM_RAT (5-335): 7.81e-71: 227: 25.22
+	Hs
		428898 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		ADRB2_HUMAN (1-328): 9.21e-69: 222: 18.68
+	Hs
		433268 YES_HUMAN (868-1151): 1.52e-97: 322: 30.53		CCR1_HUMAN (7-335): 4.97e-71: 226: 25.00
+	Hs
		522834 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		CCR2_HUMAN (7-316): 9.26e-69: 221: 25.16
+	Hs
		846452 BLK_HUMAN (853-1152): 7.51e-90: 300: 28.15		CXCR4_HUMAN (7-311): 7.44e-68: 218: 27.60
+	Hs
		522872 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		PAR2_HUMAN (23-303): 8.99e-35: 132: 30.28
+	Hs
		433299 YES_HUMAN (868-1151): 1.52e-97: 322: 30.53		PAR2_HUMAN (23-303): 8.99e-35: 132: 30.28
+	Hs
		433665 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		PAR2_HUMAN (23-303): 8.99e-35: 132: 30.28
+	Hs
		669140 TYK2_HUMAN (867-1152): 1.57e-32: 139: 19.00		LPAR6_HUMAN (1-344): 1e-69: 222: 100.00
+	Hs
		626769 TYK2_HUMAN (867-1152): 1.57e-32: 139: 19.00		PTAFR_HUMAN (5-312): 8.64e-41: 147: 28.80