Protein: SDC1
Syndecan-1 (SYND1) (CD antigen CD138)

Gene: SDC1
Organism: Homo sapiens
Interactions: 157
UniProt ID: P18827

Gene Ontology (top 5):
GO:0005796 - Golgi lumen
GO:0005886 - plasma membrane
GO:0006898 - receptor-mediated endocytosis
GO:0009897 - external side of plasma membrane
GO:0009986 - cell surface

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

616724

SDC2
Syndecan-2

2

15

Small-scale

0.799

High

478443

FGF2
Fibroblast growth factor 2

5

9

Small-scale

0.709

High

616713

SDC1
Syndecan-1

1

15

Small-scale

0.680

High

193497

PDPK1
3-phosphoinositide-dependent protein kinase 1

4

2

High-throughput

0.678

High

616756

OCLN
Occludin

3

1

High-throughput

0.662

High

616778

CAMKV
CaM kinase-like vesicle-associated protein

3

2

High-throughput

0.662

High

616781

VANG1
Vang-like protein 1

3

5

High-throughput

0.662

High

269902

SDC3
Syndecan-3

1

15

Small-scale

0.647

High

616720

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

2

3

High-throughput

0.628

High

616721

EPHA2
Ephrin type-A receptor 2

2

4

High-throughput

0.628

High

616738

KC1G2
Casein kinase I isoform gamma-2

2

1

High-throughput

0.628

High

616827

KC1G3
Casein kinase I isoform gamma-3

2

1

High-throughput

0.628

High

421466

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.611

High

374389

RASH
GTPase HRas

2

2

High-throughput

0.611

High

616741

AMPD2
AMP deaminase 2

3

2

High-throughput

0.604

High

616751

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

3

4

High-throughput

0.604

High

616821

GMEB2
Glucocorticoid modulatory element-binding protein 2

3

5

High-throughput

0.604

High

616825

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

3

5

High-throughput

0.604

High

616826

GMEB1
Glucocorticoid modulatory element-binding protein 1

3

5

High-throughput

0.604

High

125875

ARVC
Splicing regulator ARVCF

2

0

High-throughput

0.602

High

616752

EFR3A
Protein EFR3 homolog A

2

0

High-throughput

0.602

High

616766

EEPD1
Endonuclease/exonuclease/phosphatase family domain-containing protein 1

2

0

High-throughput

0.602

High

616779

CCNY
Cyclin-Y

2

0

High-throughput

0.602

High

616809

GBB4
Guanine nucleotide-binding protein subunit beta-4

2

0

High-throughput

0.602

High

616810

PRD10
PR domain zinc finger protein 10

2

4

High-throughput

0.574

High

616819

PARP2
Poly [ADP-ribose] polymerase 2

2

2

High-throughput

0.574

High

395460

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

616750

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

4

Small-scale

0.566

High

616761

IFIX
Pyrin and HIN domain-containing protein 1

2

3

High-throughput

0.558

High

592615

ITB4
Integrin beta-4

1

7

Small-scale

0.552

High

426934

FGF1
Fibroblast growth factor 1

2

9

High-throughput

0.549

High

616726

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

6

High-throughput

0.549

High

616818

DAXX
Death domain-associated protein 6

2

1

High-throughput

0.549

High

518579

RAP2A
Ras-related protein Rap-2a

1

1

High-throughput

0.536

High

520672

RRAS
Ras-related protein R-Ras

1

3

High-throughput

0.536

High

616727

MNDA
Myeloid cell nuclear differentiation antigen

1

3

High-throughput

0.536

High

616747

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.536

High

564795

NCAM1
Neural cell adhesion molecule 1

1

0

High-throughput

0.513

High

616714

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

0

High-throughput

0.513

High

616723

CGL
Cystathionine gamma-lyase

1

0

High-throughput

0.513

High

616753

RFTN1
Raftlin

1

0

High-throughput

0.513

High

616793

ERMAP
Erythroid membrane-associated protein

1

0

High-throughput

0.513

High

616811

XPP1
Xaa-Pro aminopeptidase 1

1

0

High-throughput

0.513

High

616812

PICK1
PRKCA-binding protein

1

0

High-throughput

0.513

High

518760

IL8
Interleukin-8

1

1

Small-scale

0.512

High

168633

CSKP
Peripheral plasma membrane protein CASK

1

4

Small-scale

0.501

High

469774

CATG
Cathepsin G

1

1

Small-scale

0.501

High

477400

CD63
CD63 antigen

1

3

Small-scale

0.501

High

507508

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

616734

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.501

High

472379

FGF4
Fibroblast growth factor 4

1

9

High-throughput

0.489

High

616791

PRRC1
Protein PRRC1

1

1

High-throughput

0.489

High

616816

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.489

High

140140

SDCB1
Syntenin-1

1

5

Small-scale

0.479

High

400252

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

410605

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

6

Small-scale

0.479

High

440352

FYN
Tyrosine-protein kinase Fyn

1

3

Small-scale

0.479

High

616717

CD9
CD9 antigen

1

3

Small-scale

0.479

High

616755

PCOC1
Procollagen C-endopeptidase enhancer 1

1

1

Small-scale

0.479

High

616757

LAMA3
Laminin subunit alpha-3

1

1

Small-scale

0.479

High

616739

VIGLN
Vigilin

1

0

High-throughput

0.458

High

571175

HGF
Hepatocyte growth factor

1

1

Small-scale

0.457

High

136476

GOLI4
Golgi integral membrane protein 4

1

1

High-throughput

0.445

High

346729

CAVN2
Caveolae-associated protein 2

1

2

High-throughput

0.445

High

616718

FGFR4
Fibroblast growth factor receptor 4

1

5

High-throughput

0.445

High

616719

KALM
Anosmin-1

1

3

High-throughput

0.445

High

616722

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

5

High-throughput

0.445

High

616725

MERL
Merlin

1

8

High-throughput

0.445

High

616728

P2RY1
P2Y purinoceptor 1

1

4

High-throughput

0.445

High

616730

NUMB
Protein numb homolog

1

1

High-throughput

0.445

High

616731

EFNB2
Ephrin-B2

1

3

High-throughput

0.445

High

616733

CD81
CD81 antigen

1

3

High-throughput

0.445

High

616736

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.445

High

616762

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.445

High

616770

C2CD5
C2 domain-containing protein 5

1

5

High-throughput

0.445

High

616772

KLHL7
Kelch-like protein 7

1

2

High-throughput

0.445

High

616775

LAT4
Large neutral amino acids transporter small subunit 4

1

1

High-throughput

0.445

High

616776

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

1

High-throughput

0.445

High

616782

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.445

High

616783

TRPM4
Transient receptor potential cation channel subfamily M member 4

1

2

High-throughput

0.445

High

616785

SNX33
Sorting nexin-33

1

3

High-throughput

0.445

High

616787

GSLG1
Golgi apparatus protein 1

1

1

High-throughput

0.445

High

616789

EXOC2
Exocyst complex component 2

1

1

High-throughput

0.445

High

616796

SNX18
Sorting nexin-18

1

3

High-throughput

0.445

High

616799

SEM3C
Semaphorin-3C

1

1

High-throughput

0.445

High

616800

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.445

High

616814

EXOC1
Exocyst complex component 1

1

1

High-throughput

0.445

High

616822

VANG2
Vang-like protein 2

1

5

High-throughput

0.445

High

371121

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

562865

CCL5
C-C motif chemokine 5

1

1

Small-scale

0.437

High

616746

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.437

High

616786

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

65331

TCAF2
TRPM8 channel-associated factor 2

1

0

High-throughput

0.426

High

154558

PLPP3
Phospholipid phosphatase 3

1

0

High-throughput

0.426

High

220564

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.426

High

250922

TPST1
Protein-tyrosine sulfotransferase 1

1

0

High-throughput

0.426

High

279277

TULP3
Tubby-related protein 3

1

0

High-throughput

0.426

High

291051

UTP20
Small subunit processome component 20 homolog

1

0

High-throughput

0.426

High

296903

DGAT1
Diacylglycerol O-acyltransferase 1

1

0

High-throughput

0.426

High

616716

AOC1
Diamine oxidase [copper-containing]

1

0

High-throughput

0.426

High

616740

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.426

High

616744

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.426

High

616760

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

0

High-throughput

0.426

High

616771

FMNL3
Formin-like protein 3

1

0

High-throughput

0.426

High

616777

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.426

High

616798

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

0

High-throughput

0.426

High

616823

HPSE
Heparanase

1

0

High-throughput

0.426

High

215976

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

2

High-throughput

0.407

High

252823

EXOC3
Exocyst complex component 3

1

1

High-throughput

0.407

High

269989

XYLK
Glycosaminoglycan xylosylkinase

1

1

Small-scale

0.407

High

337679

SGPL1
Sphingosine-1-phosphate lyase 1

1

2

High-throughput

0.407

High

616715

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.407

High

616732

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

3

High-throughput

0.407

High

616735

MAX
Protein max

1

2

High-throughput

0.407

High

616737

GTF2I
General transcription factor II-I

1

1

High-throughput

0.407

High

616745

ECHP
Peroxisomal bifunctional enzyme

1

6

High-throughput

0.407

High

616748

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

1

High-throughput

0.407

High

616749

TF3C1
General transcription factor 3C polypeptide 1

1

2

High-throughput

0.407

High

616754

KIF22
Kinesin-like protein KIF22

1

1

High-throughput

0.407

High

616758

KLH12
Kelch-like protein 12

1

2

High-throughput

0.407

High

616764

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

2

High-throughput

0.407

High

616767

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

7

High-throughput

0.407

High

616768

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

6

High-throughput

0.407

High

616773

SLN12
Ribonuclease SLFN12

1

1

High-throughput

0.407

High

616784

EOLA1
Protein EOLA1

1

2

High-throughput

0.407

High

616792

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

1

1

High-throughput

0.407

High

616794

TREF1
Transcriptional-regulating factor 1

1

2

High-throughput

0.407

High

616795

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.407

High

616802

DHRS4
Dehydrogenase/reductase SDR family member 4

1

4

High-throughput

0.407

High

616803

OSBL8
Oxysterol-binding protein-related protein 8

1

3

High-throughput

0.407

High

616807

OSBL5
Oxysterol-binding protein-related protein 5

1

3

High-throughput

0.407

High

616817

KANL3
KAT8 regulatory NSL complex subunit 3

1

1

High-throughput

0.407

High

616824

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

4

High-throughput

0.407

High

616742

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

2

0

High-throughput

0.328

High

616804

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.328

High

616806

LACRT
Extracellular glycoprotein lacritin

2

0

Small-scale

0.298

High

517283

ZTRF1
Zinc finger TRAF-type-containing protein 1

2

0

High-throughput

0.288

High

215252

TXNL1
Thioredoxin-like protein 1

1

0

High-throughput

0.279

Low

616729

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.279

Low

616763

FBX46
F-box only protein 46

1

0

High-throughput

0.279

Low

616797

CDCA3
Cell division cycle-associated protein 3

1

0

High-throughput

0.279

Low

616820

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.279

Low

347519

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.249

Low

616765

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

616743

ERCC6
DNA excision repair protein ERCC-6

1

0

High-throughput

0.232

Low

616759

M17L2
Mpv17-like protein 2

1

0

High-throughput

0.232

Low

616769

FBX11
F-box only protein 11

1

0

High-throughput

0.232

Low

616774

ASPM
Abnormal spindle-like microcephaly-associated protein

1

0

High-throughput

0.232

Low

616780

DIK2A
Divergent protein kinase domain 2A

1

0

High-throughput

0.232

Low

616788

TM101
Transmembrane protein 101

1

0

High-throughput

0.232

Low

616790

B3GT6
Beta-1,3-galactosyltransferase 6

1

0

High-throughput

0.232

Low

616801

CABL2
CDK5 and ABL1 enzyme substrate 2

1

0

High-throughput

0.232

Low

616805

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.232

Low

616808

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.232

Low

616813

DCA13
DDB1- and CUL4-associated factor 13

1

0

High-throughput

0.232

Low

616815

TM160
Transmembrane protein 160

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025