HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27362806, 24413661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding and 1 others more... GO:0046677 - response to antibiotic
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1154 Hs			1 491
+	Hs
		337432 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		789057 ABL2_HUMAN (833-1153): 1.44e-93: 327: 28.88		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		522916 SRC_HUMAN (868-1151): 7e-99: 326: 31.23		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		442809 HCK_HUMAN (853-1152): 4.44e-92: 307: 31.56		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		169224 ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72		MDM4_HUMAN (4-489): 0: 531: 32.08
+	Hs
		962790 ERBB4_HUMAN (577-848): 1.87e-14: 80.5: 26.64		MDM2_HUMAN (1-491): 0: 710: 100.00
+	Hs
		169239 FGFR4_HUMAN (566-848): 2.44e-13: 76.6: 25.65		MDM4_HUMAN (4-489): 0: 531: 32.08