HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25192599
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 406
+	Hs
		1271148 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		571537 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		1051938 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		571333 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		726967 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		726627 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		571409 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		967316 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		1271695 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		571634 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		571648 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		757802 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		757814 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		892947 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Dm
		1360018 RBM8A_DROME (221-366): 1.61e-20: 90.4: 21.62		IF4A3_DROME (9-406): 2.49e-132: 387: 68.09
+	Hs
		892791 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		640342 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		640666 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		640681 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		640464 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71