HitPredict

Interactor 1: H2B1O (P23527)
Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n)
Gene: H2BC17

Interactor 2: PARP4 (Q9UKK3)
Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP)
Gene: PARP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 1724
+	Hs
		1274474 H2B1H_HUMAN (1-126): 3.39e-55: 169: 99.21		PARP4_HUMAN (1-1724): 0: 2201: 100.00
+	Hs
		241659 H2B1K_HUMAN (1-126): 1.05e-54: 168: 97.62		PARP4_HUMAN (1-1724): 0: 2201: 100.00
+	Hs
		455094 H2B1O_HUMAN (1-126): 1.76e-55: 170: 100.00		PARP1_HUMAN (21-570): 0: 640: 21.52
+	Hs
		455301 H2B1C_HUMAN (1-126): 7.88e-55: 169: 98.41		PARP1_HUMAN (21-570): 0: 640: 21.52
+	Hs
		455500 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		PARP1_HUMAN (21-570): 0: 640: 21.52
+	Hs
		455733 H2B1H_HUMAN (1-126): 3.39e-55: 169: 99.21		PARP1_HUMAN (21-570): 0: 640: 21.52
+	Hs
		455136 H2B1B_HUMAN (1-126): 1.21e-54: 168: 97.62		PARP1_HUMAN (21-570): 0: 640: 21.52
+	Hs
		455276 H2B1D_HUMAN (1-126): 2.25e-54: 168: 97.62		PARP1_HUMAN (21-570): 0: 640: 21.52
+	Hs
		455645 H2B3B_HUMAN (1-126): 1.1e-52: 163: 96.83		PARP1_HUMAN (21-570): 0: 640: 21.52
+	Hs
		455738 H2B1A_HUMAN (1-126): 8.17e-48: 151: 85.04		PARP1_HUMAN (21-570): 0: 640: 21.52
+	Dm
		355257 H2B_DROME (36-126): 5.91e-47: 149: 95.60		PARP_DROME (20-566): 0: 579: 18.71
+	Hs
		1087460 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		PARP2_HUMAN (100-571): 2.07e-177: 548: 21.07
+	Hs
		918755 H2B1C_HUMAN (1-126): 7.88e-55: 169: 98.41		PARP2_HUMAN (100-571): 2.07e-177: 548: 21.07
+	Hs
		707781 H2B1B_HUMAN (1-126): 1.21e-54: 168: 97.62		PARP2_HUMAN (100-571): 2.07e-177: 548: 21.07
+	Hs
		1231259 H2B3B_HUMAN (1-126): 1.1e-52: 163: 96.83		PARP2_HUMAN (100-571): 2.07e-177: 548: 21.07
+	Hs
		1282979 H2B1A_HUMAN (1-126): 8.17e-48: 151: 85.04		PARP2_HUMAN (100-571): 2.07e-177: 548: 21.07
+	Hs
		1087180 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		VW5B1_HUMAN (617-1343): 6.64e-139: 465: 17.72
+	Hs
		1087515 H2B2E_HUMAN (1-126): 4.92e-55: 169: 99.21		PARP3_HUMAN (102-566): 6.23e-124: 401: 18.35