Protein: NF1
Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]

Gene: NF1
Organism: Homo sapiens
Interactions: 189
UniProt ID: P21359

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001525 - angiogenesis
GO:0001649 - osteoblast differentiation
GO:0001656 - metanephros development
GO:0001666 - response to hypoxia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

374397

RASH
GTPase HRas

4

20

Small-scale

0.887

High

375172

RASK
GTPase KRas

3

20

High-throughput

0.827

High

373770

RASN
GTPase NRas

2

20

Small-scale

0.768

High

637887

1433F
14-3-3 protein eta

4

20

Small-scale

0.694

High

637885

IRF8
Interferon regulatory factor 8

4

2

Small-scale

0.683

High

637853

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.678

High

637976

CAH14
Carbonic anhydrase 14

3

1

High-throughput

0.667

High

637841

EPHA1
Ephrin type-A receptor 1

3

12

High-throughput

0.662

High

637963

SCN3B
Sodium channel regulatory subunit beta-3

3

4

High-throughput

0.662

High

637918

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

2

11

Small-scale

0.653

High

637982

TN13B
Tumor necrosis factor ligand superfamily member 13B

3

0

High-throughput

0.638

High

637916

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

3

0

High-throughput

0.634

High

439947

LCK
Tyrosine-protein kinase Lck

3

19

High-throughput

0.633

High

637864

5HT6R
5-hydroxytryptamine receptor 6

2

2

Small-scale

0.624

High

601172

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

637873

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

637874

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

637875

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

637878

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

637879

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

637954

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

637970

NGAP
Ras GTPase-activating protein nGAP

1

14

High-throughput

0.618

High

637979

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.618

High

637857

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.602

High

637927

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.602

High

637930

F174A
Membrane protein FAM174A

2

0

High-throughput

0.602

High

637903

CD226
CD226 antigen

2

10

High-throughput

0.601

High

217825

TGON2
Trans-Golgi network integral membrane protein 2

2

6

High-throughput

0.584

High

362760

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.584

High

637938

FAF2
FAS-associated factor 2

2

1

Small-scale

0.579

High

637922

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

5

High-throughput

0.574

High

637869

LIMK2
LIM domain kinase 2

1

14

Small-scale

0.573

High

637868

EFNB2
Ephrin-B2

2

4

High-throughput

0.571

High

637983

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

5

High-throughput

0.571

High

637862

YAP1
Transcriptional coactivator YAP1

1

12

Small-scale

0.561

High

637870

TERA
Transitional endoplasmic reticulum ATPase

1

5

Small-scale

0.561

High

637876

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

637877

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.554

High

637880

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.554

High

211977

EFS
Embryonal Fyn-associated substrate

1

7

High-throughput

0.541

High

637846

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

637854

CD80
T-lymphocyte activation antigen CD80

1

4

High-throughput

0.536

High

637860

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

637867

EFNA4
Ephrin-A4

1

4

High-throughput

0.536

High

637882

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.536

High

637883

EFNB1
Ephrin-B1

1

4

High-throughput

0.536

High

637928

ARRD4
Arrestin domain-containing protein 4

1

3

High-throughput

0.536

High

637937

ARRD3
Arrestin domain-containing protein 3

1

3

High-throughput

0.536

High

637943

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

637947

CDHR2
Cadherin-related family member 2

1

5

High-throughput

0.536

High

637950

SEM4C
Semaphorin-4C

1

1

High-throughput

0.536

High

637972

KS6A6
Ribosomal protein S6 kinase alpha-6

1

4

High-throughput

0.536

High

637988

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

421492

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.529

High

637900

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

5

High-throughput

0.515

High

71193

HIDE1
Protein HIDE1

1

0

High-throughput

0.513

High

378608

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.513

High

388158

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

486541

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

570832

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

637842

EVI2A
Protein EVI2A

1

0

High-throughput

0.513

High

637872

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

High-throughput

0.513

High

637924

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

637940

OPALI
Opalin

1

0

High-throughput

0.513

High

637952

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

637955

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

637968

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

637971

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

637855

SDC2
Syndecan-2

1

3

Small-scale

0.508

High

400275

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.501

High

637849

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.501

High

637852

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

High-throughput

0.501

High

637861

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

13

High-throughput

0.501

High

637863

CLK1
Dual specificity protein kinase CLK1

1

6

High-throughput

0.501

High

637888

SOX4
Transcription factor SOX-4

1

4

High-throughput

0.501

High

176797

DCLK1
Serine/threonine-protein kinase DCLK1

1

17

High-throughput

0.479

High

208620

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

6

High-throughput

0.479

High

222716

PRC1
Protein regulator of cytokinesis 1

1

6

High-throughput

0.479

High

230501

KIF1C
Kinesin-like protein KIF1C

1

8

High-throughput

0.479

High

245198

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

8

High-throughput

0.479

High

252009

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

269509

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

6

High-throughput

0.479

High

281282

GGYF1
GRB10-interacting GYF protein 1

1

4

High-throughput

0.479

High

299063

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

339056

NADK
NAD kinase

1

1

High-throughput

0.479

High

371154

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

403819

GCR
Glucocorticoid receptor

1

9

High-throughput

0.479

High

446643

NPM
Nucleophosmin

1

2

High-throughput

0.479

High

459456

PROF1
Profilin-1

1

1

High-throughput

0.479

High

463328

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.479

High

571556

IRF2
Interferon regulatory factor 2

1

2

Small-scale

0.479

High

587907

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

609900

SPI1
Transcription factor PU.1

1

1

Small-scale

0.479

High

627501

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

2

High-throughput

0.479

High

637843

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.479

High

637845

PTBP1
Polypyrimidine tract-binding protein 1

1

5

High-throughput

0.479

High

637847

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

637850

MPIP2
M-phase inducer phosphatase 2

1

3

High-throughput

0.479

High

637851

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.479

High

637856

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

637858

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

637859

MUC18
Cell surface glycoprotein MUC18

1

7

High-throughput

0.479

High

637865

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

6

Small-scale

0.479

High

637866

DHB4
Peroxisomal multifunctional enzyme type 2

1

1

High-throughput

0.479

High

637871

HDAC4
Histone deacetylase 4

1

6

High-throughput

0.479

High

637881

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.479

High

637884

CDK16
Cyclin-dependent kinase 16

1

4

High-throughput

0.479

High

637886

CAV1
Caveolin-1

1

6

Small-scale

0.479

High

637889

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

11

High-throughput

0.479

High

637890

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

9

High-throughput

0.479

High

637891

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

8

High-throughput

0.479

High

637892

SLAF1
Signaling lymphocytic activation molecule

1

7

High-throughput

0.479

High

637893

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

637894

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

11

High-throughput

0.479

High

637895

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

12

High-throughput

0.479

High

637896

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

11

High-throughput

0.479

High

637897

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.479

High

637898

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.479

High

637899

ZN638
Zinc finger protein 638

1

3

High-throughput

0.479

High

637901

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

637902

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

10

High-throughput

0.479

High

637904

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

637906

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

4

High-throughput

0.479

High

637907

SPD2A
SH3 and PX domain-containing protein 2A

1

8

High-throughput

0.479

High

637909

DEN4C
DENN domain-containing protein 4C

1

5

High-throughput

0.479

High

637912

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.479

High

637913

GGYF2
GRB10-interacting GYF protein 2

1

12

High-throughput

0.479

High

637914

SYDE1
Rho GTPase-activating protein SYDE1

1

9

High-throughput

0.479

High

637915

MYCPP
C-myc promoter-binding protein

1

5

High-throughput

0.479

High

637919

PHLB2
Pleckstrin homology-like domain family B member 2

1

11

High-throughput

0.479

High

637921

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

2

High-throughput

0.479

High

637923

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.479

High

637925

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

3

High-throughput

0.479

High

637926

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

637929

NAV1
Neuron navigator 1

1

9

High-throughput

0.479

High

637931

F110B
Protein FAM110B

1

2

High-throughput

0.479

High

637932

DEN1A
DENN domain-containing protein 1A

1

8

High-throughput

0.479

High

637934

SRS12
Serine/arginine-rich splicing factor 12

1

8

High-throughput

0.479

High

637935

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

637941

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.479

High

637942

TESK2
Dual specificity testis-specific protein kinase 2

1

3

High-throughput

0.479

High

637944

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

637945

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.479

High

637946

RTKN
Rhotekin

1

1

High-throughput

0.479

High

637951

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

637953

UN45A
Protein unc-45 homolog A

1

4

High-throughput

0.479

High

637956

TANC2
Protein TANC2

1

7

High-throughput

0.479

High

637958

KI13B
Kinesin-like protein KIF13B

1

8

High-throughput

0.479

High

637959

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.479

High

637960

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

5

High-throughput

0.479

High

637964

FA53C
Protein FAM53C

1

1

High-throughput

0.479

High

637965

PD1L1
Programmed cell death 1 ligand 1

1

9

High-throughput

0.479

High

637966

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.479

High

637967

CING
Cingulin

1

8

High-throughput

0.479

High

637969

LIMA1
LIM domain and actin-binding protein 1

1

9

High-throughput

0.479

High

637973

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

High-throughput

0.479

High

637974

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

637975

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

637977

ALK
ALK tyrosine kinase receptor

1

19

High-throughput

0.479

High

637981

GAB2
GRB2-associated-binding protein 2

1

14

High-throughput

0.479

High

637984

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

637985

STA13
StAR-related lipid transfer protein 13

1

7

High-throughput

0.479

High

637986

TRAF6
TNF receptor-associated factor 6

1

12

Small-scale

0.479

High

637987

KCTD3
BTB/POZ domain-containing protein KCTD3

1

8

High-throughput

0.479

High

366395

FA12
Coagulation factor XII

1

0

Small-scale

0.458

High

637936

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

637939

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

637949

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

637978

NSF1C
NSFL1 cofactor p47

1

0

Small-scale

0.458

High

166255

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

3

High-throughput

0.445

High

262207

SCN2B
Sodium channel regulatory subunit beta-2

1

4

High-throughput

0.445

High

637840

FPR1
fMet-Leu-Phe receptor

1

4

High-throughput

0.445

High

637844

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

High-throughput

0.445

High

637848

5HT1E
5-hydroxytryptamine receptor 1E

1

2

High-throughput

0.445

High

637910

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.445

High

637962

S39A9
Zinc transporter ZIP9

1

4

High-throughput

0.445

High

637989

NPTN
Neuroplastin

1

2

High-throughput

0.445

High

637911

AN34A
Ankyrin repeat domain-containing protein 34A

1

14

High-throughput

0.437

High

637933

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

13

High-throughput

0.437

High

171398

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.426

High

637905

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

637908

FAXC
Failed axon connections homolog

1

0

High-throughput

0.426

High

637920

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.426

High

637961

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

637980

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.426

High

637957

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.407

High

253811

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

637917

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

637948

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025