HitPredict

Interactor 1: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Interactor 2: Q1KLZ0 (Q1KLZ0)
Actin, cytoplasmic 1 (Beta-actin)
Gene: PS1TP5BP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Hs			1 375
+	Hs
		618104 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Mm
		578583 COF1_MOUSE (1-166): 1.35e-72: 217: 98.80		ACTB_MOUSE (1-375): 0: 603: 100.00
+	Rn
		799735 COF1_RAT (1-166): 3.11e-72: 216: 99.40		ACTB_RAT (1-375): 0: 603: 100.00
+	Hs
		618038 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		1092828 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		Q1KLZ0_HUMAN (1-375): 0: 603: 100.00
+	Hs
		891817 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		892124 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		618049 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		929891 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		930059 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		891649 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		894665 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		Q1KLZ0_HUMAN (1-375): 0: 603: 100.00
+	Hs
		894652 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		618052 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		618053 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		618046 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		932464 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		618050 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTH_HUMAN (2-375): 0: 589: 93.58
+	Hs
		894651 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Sp
		501582 COFI_SCHPO (3-151): 4.28e-46: 149: 33.56		ACT_SCHPO (1-375): 0: 592: 90.40