HitPredict

Interactor 1: CDK2 (P23573)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 cognate)
Gene: CDK2

Interactor 2: CKS1 (Q24152)
Cyclin-dependent kinases regulatory subunit
Gene: Cks30A

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	7809159
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0006468 - protein phosphorylation GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Dm			1 74
+	Hs
		625283 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CKS1_HUMAN (3-71): 2.44e-35: 115: 78.26
+	Hs
		625164 CDK2_HUMAN (5-293): 1.16e-155: 438: 64.73		CKS2_HUMAN (3-71): 2.12e-33: 111: 78.26
+	Hs
		895413 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CKS1_HUMAN (3-71): 2.44e-35: 115: 78.26
+	Dm
		618471 CDK2_DROME (1-314): 2.57e-144: 410: 100.00		Q9VHN1_DROME (2-72): 5.11e-38: 123: 64.79
+	Hs
		706796 CDK3_HUMAN (5-300): 3.85e-149: 422: 62.54		CKS2_HUMAN (3-71): 2.12e-33: 111: 78.26
+	At
		188136 CDKA1_ARATH (5-290): 7.77e-139: 395: 58.76		CKS1_ARATH (4-71): 1.59e-36: 119: 67.65
+	Hs
		414843 CDK1_HUMAN (5-292): 7.45e-140: 398: 57.19		CKS1_HUMAN (3-71): 2.44e-35: 115: 78.26
+	At
		621728 CDKA1_ARATH (5-290): 7.77e-139: 395: 58.76		CKS2_ARATH (4-71): 2.82e-36: 118: 69.12
+	Dm
		618387 CDK1_DROME (5-291): 5.25e-136: 388: 59.11		CKS1_DROME (1-74): 2.1e-38: 123: 100.00
+	Dm
		618415 CDK1_DROME (5-291): 5.25e-136: 388: 59.11		Q9VHN1_DROME (2-72): 5.11e-38: 123: 64.79
+	Hs
		414778 CDK1_HUMAN (5-292): 7.45e-140: 398: 57.19		CKS2_HUMAN (3-71): 2.12e-33: 111: 78.26
+	Hs
		895414 CDK5_HUMAN (5-293): 4.41e-138: 393: 49.32		CKS1_HUMAN (3-71): 2.44e-35: 115: 78.26
+	Ce
		712291 CDK1_CAEEL (5-299): 2.49e-132: 380: 55.88		CKS1_CAEEL (2-71): 7.05e-40: 127: 62.86
+	At
		1321299 CDKD1_ARATH (2-309): 1.28e-133: 386: 41.10		CKS2_ARATH (4-71): 2.82e-36: 118: 69.12
+	Hs
		706797 CDK5_HUMAN (5-293): 4.41e-138: 393: 49.32		CKS2_HUMAN (3-71): 2.12e-33: 111: 78.26
+	At
		188168 CDKD3_ARATH (2-312): 4.88e-130: 377: 40.71		CKS1_ARATH (4-71): 1.59e-36: 119: 67.65
+	At
		1338686 CDKD3_ARATH (2-312): 4.88e-130: 377: 40.71		CKS2_ARATH (4-71): 2.82e-36: 118: 69.12
+	At
		188163 CDKD2_ARATH (5-305): 1.69e-130: 376: 42.38		CKS1_ARATH (4-71): 1.59e-36: 119: 67.65
+	At
		1321252 CDKD2_ARATH (5-305): 1.69e-130: 376: 42.38		CKS2_ARATH (4-71): 2.82e-36: 118: 69.12
+	Sp
		383445 CDK1_SCHPO (5-291): 2.84e-132: 379: 56.23		CKS1_SCHPO (3-72): 8.75e-32: 108: 45.57