Protein: MTHR
Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53)

Gene: MTHR, MTHFR
Organism: Homo sapiens
Interactions: 66
UniProt ID: P42898

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001843 - neural tube closure
GO:0004489 - methylenetetrahydrofolate reductase [NAD(P)H] activity
GO:0005829 - cytosol
GO:0006555 - methionine metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

844249

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

3

1

High-throughput

0.667

High

844243

MTHR
Methylenetetrahydrofolate reductase

1

2

Small-scale

0.647

High

219610

B2L11
Bcl-2-like protein 11

3

0

High-throughput

0.638

High

844256

BOREA
Borealin

3

0

High-throughput

0.638

High

618437

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

3

1

High-throughput

0.609

High

844271

NOX5
NADPH oxidase 5

2

0

High-throughput

0.602

High

640115

EPHA1
Ephrin type-A receptor 1

2

1

High-throughput

0.574

High

844264

KCNV2
Potassium voltage-gated channel subfamily V member 2

2

1

High-throughput

0.574

High

522057

BCL2
Apoptosis regulator Bcl-2

1

0

High-throughput

0.513

High

844248

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.513

High

844273

TLR10
Toll-like receptor 10

1

1

High-throughput

0.489

High

844274

KCNF1
Voltage-gated potassium channel regulatory subunit KCNF1

1

1

High-throughput

0.489

High

844277

TLR9
Toll-like receptor 9

1

1

High-throughput

0.489

High

253592

IMA7
Importin subunit alpha-7

1

0

High-throughput

0.458

High

279296

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

844268

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

High-throughput

0.458

High

258795

DNJA2
DnaJ homolog subfamily A member 2

1

2

Small-scale

0.445

High

727715

DNJA1
DnaJ homolog subfamily A member 1

1

2

Small-scale

0.445

High

844252

CKAP5
Cytoskeleton-associated protein 5

1

1

Small-scale

0.445

High

844266

GCN1
Stalled ribosome sensor GCN1

1

1

Small-scale

0.445

High

710678

EPHA8
Ephrin type-A receptor 8

1

1

High-throughput

0.437

High

402547

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.426

High

429468

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

547565

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

Small-scale

0.426

High

731049

STIP1
Stress-induced-phosphoprotein 1

1

0

Small-scale

0.426

High

834388

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.426

High

844245

ACLY
ATP-citrate synthase

1

0

Small-scale

0.426

High

844246

COPA
Coatomer subunit alpha

1

0

Small-scale

0.426

High

844250

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

Small-scale

0.426

High

844253

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.426

High

844260

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

Small-scale

0.426

High

844282

RUVB2
RuvB-like 2

1

0

Small-scale

0.426

High

844244

SL9A3
Sodium/hydrogen exchanger 3

1

3

High-throughput

0.407

High

844254

SL9A5
Sodium/hydrogen exchanger 5

1

3

High-throughput

0.407

High

844258

SL9A4
Sodium/hydrogen exchanger 4

1

3

High-throughput

0.407

High

844281

SL9A2
Sodium/hydrogen exchanger 2

1

3

High-throughput

0.407

High

844280

RASF1
Ras association domain-containing protein 1

3

0

High-throughput

0.347

High

261118

NSMA
Sphingomyelin phosphodiesterase 2

3

0

High-throughput

0.345

High

49441

TM223
Transmembrane protein 223

2

0

High-throughput

0.328

High

686681

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

2

0

High-throughput

0.328

High

844255

TIGD6
Tigger transposable element-derived protein 6

2

0

High-throughput

0.328

High

844261

SPT19
Spermatogenesis-associated protein 19, mitochondrial

2

0

High-throughput

0.328

High

844265

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.328

High

844278

PCDBG
Protocadherin beta-16

2

0

High-throughput

0.328

High

844276

SP110
Sp110 nuclear body protein

2

0

High-throughput

0.318

High

137500

BT3A1
Butyrophilin subfamily 3 member A1

1

0

High-throughput

0.279

Low

171844

ZN263
Zinc finger protein 263

1

0

High-throughput

0.279

Low

230942

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.279

Low

505086

BNIP5
Protein BNIP5

1

0

High-throughput

0.279

Low

692467

G0S2
G0/G1 switch protein 2

1

0

High-throughput

0.279

Low

844247

GDF10
Growth/differentiation factor 10

1

0

High-throughput

0.279

Low

844257

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

844262

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.279

Low

844263

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

844269

COX42
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

1

0

High-throughput

0.279

Low

844272

DCR1C
Protein artemis

1

0

High-throughput

0.279

Low

844275

ZN556
Zinc finger protein 556

1

0

High-throughput

0.279

Low

344519

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.265

Low

315238

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

844251

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

844259

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

844267

ARK2N
Protein ARK2N

1

0

High-throughput

0.249

Low

844279

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.249

Low

844270

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

844283

S12A7
Solute carrier family 12 member 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025