Protein: GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)

Gene: GNAI1
Organism: Homo sapiens
Interactions: 152
UniProt ID: P63096

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001664 - G protein-coupled receptor binding
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

220444

RGS14
Regulator of G-protein signaling 14

7

20

Small-scale

0.966

High

989893

GPSM3
G-protein-signaling modulator 3

6

3

Small-scale

0.955

High

989882

RIC8A
Chaperone Ric-8A

5

13

Small-scale

0.927

High

168040

RGS12
Regulator of G-protein signaling 12

4

20

Small-scale

0.902

High

989851

GPSM1
G-protein-signaling modulator 1

4

15

Small-scale

0.899

High

475941

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

4

11

High-throughput

0.895

High

70937

GNAT3
Guanine nucleotide-binding protein G(t) subunit alpha-3

3

11

High-throughput

0.861

High

482601

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

3

14

High-throughput

0.861

High

869722

MTR1A
Melatonin receptor type 1A

2

20

Small-scale

0.819

High

880902

MTR1B
Melatonin receptor type 1B

2

19

Small-scale

0.819

High

890698

RGS4
Regulator of G-protein signaling 4

2

20

Small-scale

0.778

High

418645

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

11

High-throughput

0.754

High

890627

RGS19
Regulator of G-protein signaling 19

2

20

Small-scale

0.754

High

303125

RGS20
Regulator of G-protein signaling 20

1

20

Small-scale

0.740

High

638179

S1PR1
Sphingosine 1-phosphate receptor 1

1

20

Small-scale

0.740

High

989889

RGS17
Regulator of G-protein signaling 17

1

20

High-throughput

0.740

High

989852

PCP2
Purkinje cell protein 2 homolog

2

11

High-throughput

0.700

High

989876

GBB4
Guanine nucleotide-binding protein subunit beta-4

4

20

Small-scale

0.696

High

983444

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

4

20

Small-scale

0.689

High

243468

GBG7

3

20

High-throughput

0.667

High

844249

MTHR
Methylenetetrahydrofolate reductase

3

1

High-throughput

0.667

High

893553

GBG4

3

20

High-throughput

0.667

High

989827

GBG5

3

20

High-throughput

0.667

High

989839

MTR1L
Melatonin-related receptor

1

20

Small-scale

0.665

High

893567

GBG10

3

20

High-throughput

0.650

High

192036

RGS16
Regulator of G-protein signaling 16

1

20

Small-scale

0.647

High

223468

RGS10
Regulator of G-protein signaling 10

1

20

Small-scale

0.647

High

458371

ADRB2
Beta-2 adrenergic receptor

1

10

Small-scale

0.647

High

641887

DRD4
D(4) dopamine receptor

1

11

Small-scale

0.647

High

989885

RGS18
Regulator of G-protein signaling 18

1

20

Small-scale

0.647

High

989828

GPSM2
G-protein-signaling modulator 2

1

14

Small-scale

0.646

High

989826

GBG3

2

20

High-throughput

0.628

High

948054

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

2

20

Small-scale

0.619

High

193887

RGS5
Regulator of G-protein signaling 5

1

20

Small-scale

0.618

High

239451

AGRB2
Adhesion G protein-coupled receptor B2

1

3

Small-scale

0.618

High

638884

CNR1
Cannabinoid receptor 1

1

18

Small-scale

0.618

High

762198

CRFR1
Corticotropin-releasing factor receptor 1

1

9

Small-scale

0.618

High

989833

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

9

Small-scale

0.618

High

989842

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

12

High-throughput

0.618

High

989875

ECT2
Protein ECT2

1

11

High-throughput

0.618

High

948769

CD81
CD81 antigen

2

8

Small-scale

0.601

High

989890

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

20

High-throughput

0.601

High

830525

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

989883

ANLN
Anillin

2

8

High-throughput

0.584

High

989887

GBG12

2

20

High-throughput

0.584

High

340445

ADCY5
Adenylate cyclase type 5

1

1

Small-scale

0.575

High

989868

SMO
Protein smoothened

1

2

Small-scale

0.575

High

989846

KPCD1
Serine/threonine-protein kinase D1

2

8

High-throughput

0.571

High

908071

GP143
G-protein coupled receptor 143

1

0

Small-scale

0.537

High

529571

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.536

High

637442

FLNA
Filamin-A

1

1

High-throughput

0.536

High

772727

MYH9
Myosin-9

1

3

High-throughput

0.536

High

989836

STK3
Serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

989840

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.536

High

989843

NUMA1
Nuclear mitotic apparatus protein 1

1

4

Small-scale

0.536

High

989850

COX15
Heme A synthase COX15

1

1

High-throughput

0.536

High

989858

HASP
Serine/threonine-protein kinase haspin

1

4

High-throughput

0.536

High

989862

MYO19
Unconventional myosin-XIX

1

5

High-throughput

0.536

High

989865

SCN2A
Sodium channel protein type 2 subunit alpha

1

11

High-throughput

0.536

High

989886

PAK5
Serine/threonine-protein kinase PAK 5

1

12

High-throughput

0.536

High

326825

SPN1
Snurportin-1

1

0

High-throughput

0.513

High

989844

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

951595

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.501

High

984060

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

20

Small-scale

0.501

High

989881

NGB
Neuroglobin

1

1

Small-scale

0.501

High

989891

RASD1
Dexamethasone-induced Ras-related protein 1

1

3

Small-scale

0.501

High

166641

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

3

High-throughput

0.489

High

791271

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

854627

RAGP1
Ran GTPase-activating protein 1

1

1

High-throughput

0.481

High

989832

NUCB1
Nucleobindin-1

1

7

High-throughput

0.481

High

619215

EPOR
Erythropoietin receptor

1

0

Small-scale

0.480

High

164311

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

222924

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

330854

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

341550

EYA4
Protein phosphatase EYA4

1

5

High-throughput

0.479

High

363107

EGFR
Epidermal growth factor receptor

1

9

Small-scale

0.479

High

400621

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

442913

PRGR
Progesterone receptor

1

10

Small-scale

0.479

High

465478

IGF1R
Insulin-like growth factor 1 receptor

1

12

Small-scale

0.479

High

466652

GLI1
Zinc finger protein GLI1

1

1

Small-scale

0.479

High

488766

FURIN
Furin

1

2

High-throughput

0.479

High

507803

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

519923

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

541428

FGFR1
Fibroblast growth factor receptor 1

1

9

Small-scale

0.479

High

572801

NCF1
Neutrophil cytosol factor 1

1

1

Small-scale

0.479

High

588430

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

593332

PGFRA
Platelet-derived growth factor receptor alpha

1

5

Small-scale

0.479

High

626455

NCF2
Neutrophil cytosol factor 2

1

2

Small-scale

0.479

High

629756

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

633907

ATP4A
Potassium-transporting ATPase alpha chain 1

1

6

Small-scale

0.479

High

651265

CBL
E3 ubiquitin-protein ligase CBL

1

3

High-throughput

0.479

High

692919

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

693287

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.479

High

695167

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

767923

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

772378

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

774276

BASI
Basigin

1

3

High-throughput

0.479

High

862012

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

911825

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

2

High-throughput

0.479

High

916642

PPP5
Serine/threonine-protein phosphatase 5

1

2

Small-scale

0.479

High

989829

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.479

High

989831

KIF23
Kinesin-like protein KIF23

1

14

High-throughput

0.479

High

989834

B2CL1
Bcl-2-like protein 1

1

1

High-throughput

0.479

High

989835

TFCP2
Alpha-globin transcription factor CP2

1

8

High-throughput

0.479

High

989845

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

989848

DUS6
Dual specificity protein phosphatase 6

1

16

High-throughput

0.479

High

989854

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

989857

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

989861

CLC4D
C-type lectin domain family 4 member D

1

4

High-throughput

0.479

High

989867

ABCA3
Phospholipid-transporting ATPase ABCA3

1

5

High-throughput

0.479

High

989871

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

989874

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

989877

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

989878

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

8

High-throughput

0.479

High

989884

DUS22
Dual specificity protein phosphatase 22

1

15

High-throughput

0.479

High

989888

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.479

High

989892

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.479

High

989870

THAP7
THAP domain-containing protein 7

1

0

High-throughput

0.460

High

336396

SVIL
Supervillin

1

0

Small-scale

0.458

High

337941

CNEP1
CTD nuclear envelope phosphatase 1

1

0

High-throughput

0.458

High

415118

MT1A
Metallothionein-1A

1

0

Small-scale

0.458

High

473903

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.458

High

576637

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.458

High

606594

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

847981

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.458

High

989837

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.458

High

989847

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

989863

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

211128

CTR4
Cationic amino acid transporter 4

1

2

High-throughput

0.445

High

254944

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

337083

NPT2B
Sodium-dependent phosphate transport protein 2B

1

3

High-throughput

0.445

High

429690

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

989830

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

989838

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.445

High

989841

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

989849

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.445

High

989856

MFSD8
Major facilitator superfamily domain-containing protein 8

1

6

High-throughput

0.445

High

989860

CTL1
Choline transporter-like protein 1

1

6

High-throughput

0.445

High

989864

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

14

High-throughput

0.445

High

989866

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.445

High

989872

S19A3
Thiamine transporter 2

1

5

High-throughput

0.445

High

989873

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

989879

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

3

High-throughput

0.445

High

989880

SO1B3
Solute carrier organic anion transporter family member 1B3

1

4

High-throughput

0.445

High

105722

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

352390

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.437

High

989855

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

989859

RN138
E3 ubiquitin-protein ligase RNF138

1

4

High-throughput

0.437

High

127046

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

989853

S22A9
Organic anion transporter 7

1

6

High-throughput

0.407

High

399273

MMP1
Interstitial collagenase

1

0

Small-scale

0.249

Low

989869

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025