HitPredict

Interactor 1: PSA2 (P23639)
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)
Gene: PRE8

Interactor 2: PSB6 (P23724)
Proteasome subunit beta type-6 (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5)
Gene: PRE7

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.916

Property	Details
Experiments	16554755, 32868373, 37968396, 22940862, 14759368
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0010499 - proteasomal ubiquitin-independent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 250 Sc			1 241
+	Dm
		771303 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSA5_DROME (6-241): 1.55e-71: 220: 18.62
+	Dm
		574014 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSA4_DROME (6-240): 3.11e-70: 217: 16.81
+	Dm
		771329 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSA6_DROME (6-240): 1.89e-70: 217: 15.97
+	Dm
		771294 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		Q7K148_DROME (6-231): 2.9e-65: 205: 18.58
+	Dm
		771285 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSB1_DROME (21-241): 8.9e-64: 200: 39.37
+	Dm
		47598 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		A0AQH0_DROME (28-236): 4.5e-59: 187: 24.88
+	Dm
		771328 PSA2_DROME (2-250): 2.44e-105: 306: 53.41		PSB3_DROME (26-241): 4.17e-59: 187: 19.64
+	Dm
		1278657 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSA6_DROME (6-240): 1.89e-70: 217: 15.97
+	Dm
		574027 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSA4_DROME (6-240): 3.11e-70: 217: 16.81
+	Sc
		619408 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PSB3_YEAST (22-241): 4.13e-67: 207: 22.87
+	Dm
		1178944 PSA5_DROME (3-250): 5e-93: 275: 30.59		Q7K148_DROME (6-231): 2.9e-65: 205: 18.58
+	Ph
		223381 PSA_PYRHO (3-248): 1.81e-98: 289: 39.02		PSB1_PYRHO (28-238): 1.34e-60: 191: 21.23
+	Sc
		619422 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PSB5_YEAST (27-231): 1.32e-62: 198: 19.02
+	Dm
		771408 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSB1_DROME (21-241): 8.9e-64: 200: 39.37
+	Mt
		191406 PSA_METTH (2-250): 3.69e-97: 285: 34.94		PSB_METTH (28-230): 4.92e-59: 187: 26.11
+	Mm
		1154361 PSA_METMP (2-250): 4.61e-94: 278: 32.93		PSB_METMP (26-232): 1.64e-59: 188: 22.60
+	Af
		191426 PSA_ARCFU (4-248): 9.59e-95: 279: 36.33		PSB_ARCFU (26-230): 3.24e-59: 187: 24.76
+	Dm
		1278656 PSA5_DROME (3-250): 5e-93: 275: 30.59		PSB3_DROME (26-241): 4.17e-59: 187: 19.64
+	Dm
		47610 PSA5_DROME (3-250): 5e-93: 275: 30.59		A0AQH0_DROME (28-236): 4.5e-59: 187: 24.88
+	Sc
		619459 PSA2_YEAST (1-250): 4.68e-95: 280: 100.00		PSB1_YEAST (28-236): 2e-51: 167: 22.01