Protein: TF2B
Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II)

Gene: TF2B, GTF2B
Organism: Homo sapiens
Interactions: 175
UniProt ID: Q00403

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0000993 - RNA polymerase II complex binding
GO:0001174 - transcriptional start site selection at RNA polymerase II promoter
GO:0004402 - histone acetyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

628747

TBP
TATA-box-binding protein

8

13

Small-scale

0.964

High

667271

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

5

Small-scale

0.866

High

976085

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

4

High-throughput

0.811

High

708890

T2EA
General transcription factor IIE subunit 1

2

1

Small-scale

0.806

High

569094

T2FB
General transcription factor IIF subunit 2

2

1

Small-scale

0.778

High

1025102

TNIP1
TNFAIP3-interacting protein 1

4

3

High-throughput

0.698

High

770378

T2FA
General transcription factor IIF subunit 1

4

2

Small-scale

0.696

High

722940

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

5

High-throughput

0.691

High

923493

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

3

High-throughput

0.691

High

621859

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

2

Small-scale

0.681

High

1025100

NC2A
Dr1-associated corepressor

3

2

High-throughput

0.675

High

912171

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

5

Small-scale

0.656

High

1025133

CBP
CREB-binding protein

3

8

Small-scale

0.651

High

975578

TBPL1
TATA box-binding protein-like 1

1

13

Small-scale

0.647

High

621625

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

7

Small-scale

0.628

High

958932

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

3

High-throughput

0.628

High

1025109

TAF9
Transcription initiation factor TFIID subunit 9

2

2

Small-scale

0.618

High

165036

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

5

Small-scale

0.618

High

522815

COT1
COUP transcription factor 1

2

2

Small-scale

0.613

High

912050

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

3

High-throughput

0.611

High

370066

CYTS
Cystatin-S

3

2

High-throughput

0.609

High

370184

CYTN
Cystatin-SN

3

2

High-throughput

0.609

High

479922

CYTT
Cystatin-SA

3

2

High-throughput

0.609

High

1025124

MUC7
Mucin-7

3

2

High-throughput

0.609

High

1025081

TF65
Transcription factor p65

2

1

Small-scale

0.602

High

1025149

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.602

High

407911

PRP1
Basic salivary proline-rich protein 1

3

2

High-throughput

0.599

High

708949

T2EB
Transcription initiation factor IIE subunit beta

2

1

Small-scale

0.595

High

1025094

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

Small-scale

0.585

High

654633

TCEA1
Transcription elongation factor A protein 1

2

3

Small-scale

0.585

High

631169

RAB5A
Ras-related protein Rab-5A

2

2

High-throughput

0.571

High

1025152

OXSM
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

2

2

High-throughput

0.558

High

65032

GG6L9
Golgin subfamily A member 6-like protein 9

2

1

High-throughput

0.553

High

1025105

TAF11
Transcription initiation factor TFIID subunit 11

1

1

Small-scale

0.550

High

1025132

TF2H4
General transcription factor IIH subunit 4

1

1

Small-scale

0.550

High

192810

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

High-throughput

0.536

High

239565

MED14
Mediator of RNA polymerase II transcription subunit 14

1

5

High-throughput

0.536

High

693695

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

787745

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

6

High-throughput

0.536

High

1025084

EP300
Histone acetyltransferase p300

1

8

Small-scale

0.527

High

458377

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.518

High

188476

NVL
Nuclear valosin-containing protein-like

1

4

High-throughput

0.515

High

288390

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

3

High-throughput

0.515

High

371774

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.515

High

877088

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.515

High

946015

VSX2
Visual system homeobox 2

1

1

High-throughput

0.515

High

977199

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.515

High

1025089

CBLB
E3 ubiquitin-protein ligase CBL-B

1

1

High-throughput

0.515

High

1025098

LPIN1
Phosphatidate phosphatase LPIN1

1

1

High-throughput

0.515

High

1025099

CBX2
Chromobox protein homolog 2

1

1

High-throughput

0.515

High

1025116

DCAF8
DDB1- and CUL4-associated factor 8

1

2

High-throughput

0.515

High

1025118

TRM1L
tRNA

1

1

High-throughput

0.515

High

1025122

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

1

High-throughput

0.515

High

1025130

JADE3
Protein Jade-3

1

1

High-throughput

0.515

High

1025156

KLF15
Krueppel-like factor 15

1

4

High-throughput

0.515

High

48941

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.513

High

608249

EGLN
Endoglin

1

0

High-throughput

0.513

High

1025142

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.513

High

1025151

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.513

High

1025153

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.513

High

379634

IGHA1
Immunoglobulin heavy constant alpha 1

2

3

High-throughput

0.504

High

278306

NCOR1
Nuclear receptor corepressor 1

1

3

Small-scale

0.501

High

395918

ESR1
Estrogen receptor

1

2

Small-scale

0.501

High

533268

THA
Thyroid hormone receptor alpha

1

3

Small-scale

0.501

High

634917

BCL3
B-cell lymphoma 3 protein

1

1

Small-scale

0.501

High

833917

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

Small-scale

0.501

High

1025080

HSF1
Heat shock factor protein 1

1

3

Small-scale

0.501

High

1025082

REL
Proto-oncogene c-Rel

1

1

Small-scale

0.501

High

1025088

REST
RE1-silencing transcription factor

1

1

Small-scale

0.501

High

1025091

STF1
Steroidogenic factor 1

1

3

Small-scale

0.501

High

1025092

CTBP1
C-terminal-binding protein 1

1

2

Small-scale

0.501

High

1025096

KLF5
Krueppel-like factor 5

1

3

Small-scale

0.501

High

1025101

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

3

Small-scale

0.501

High

183921

S22A2
Solute carrier family 22 member 2

1

3

High-throughput

0.494

High

777604

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

6

High-throughput

0.494

High

911913

JAK3
Tyrosine-protein kinase JAK3

1

1

High-throughput

0.494

High

250553

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.493

High

282234

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.493

High

517578

ZSC22
Zinc finger and SCAN domain-containing protein 22

1

0

High-throughput

0.493

High

954675

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.493

High

1025087

RED
Protein Red

1

0

High-throughput

0.493

High

1025112

ZN829
Zinc finger protein 829

1

0

High-throughput

0.493

High

1025115

PHF19
PHD finger protein 19

1

0

High-throughput

0.493

High

1025117

ASCL4
Achaete-scute homolog 4

1

0

High-throughput

0.493

High

1025121

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.493

High

1025123

SPT22
Spermatogenesis-associated protein 22

1

0

High-throughput

0.493

High

1025125

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

0

High-throughput

0.493

High

1025127

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.493

High

1025134

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.493

High

1025136

ZN488
Zinc finger protein 488

1

0

High-throughput

0.493

High

1025139

RPP25
Ribonuclease P protein subunit p25

1

0

High-throughput

0.493

High

1025140

RUSC1
AP-4 complex accessory subunit RUSC1

1

0

High-throughput

0.493

High

1025141

PBX4
Pre-B-cell leukemia transcription factor 4

1

0

High-throughput

0.493

High

1025145

HES4
Transcription factor HES-4

1

0

High-throughput

0.493

High

429738

JUN
Transcription factor Jun

1

0

Small-scale

0.480

High

617212

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.480

High

629510

PO3F2
POU domain, class 3, transcription factor 2

1

0

Small-scale

0.480

High

749468

C2TA
MHC class II transactivator

1

0

Small-scale

0.480

High

904604

MECP2
Methyl-CpG-binding protein 2

1

0

Small-scale

0.480

High

1025086

FOXF2
Forkhead box protein F2

1

0

Small-scale

0.480

High

1025093

IKZF1
DNA-binding protein Ikaros

1

0

Small-scale

0.480

High

1025095

NCOA4
Nuclear receptor coactivator 4

1

0

Small-scale

0.480

High

1025107

NCOA1
Nuclear receptor coactivator 1

1

0

Small-scale

0.480

High

1025126

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

1025147

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

131960

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

142939

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

259800

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

317826

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.479

High

408809

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

Small-scale

0.479

High

473918

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.479

High

478001

SNRPA
U1 small nuclear ribonucleoprotein A

1

6

Small-scale

0.479

High

533915

IRF1
Interferon regulatory factor 1

1

2

Small-scale

0.479

High

558046

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.479

High

571587

IRF2
Interferon regulatory factor 2

1

2

Small-scale

0.479

High

588476

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

681338

PSA3
Proteasome subunit alpha type-3

1

3

Small-scale

0.479

High

695225

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

714034

PML
Protein PML

1

1

High-throughput

0.479

High

778657

PRS7
26S proteasome regulatory subunit 7

1

3

Small-scale

0.479

High

970341

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

971408

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

980698

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

1025083

DHX9
ATP-dependent RNA helicase A

1

4

Small-scale

0.479

High

1025085

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1025090

TIF1B
Transcription intermediary factor 1-beta

1

1

Small-scale

0.479

High

1025097

IRF3
Interferon regulatory factor 3

1

2

Small-scale

0.479

High

1025103

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

1025106

MED1
Mediator of RNA polymerase II transcription subunit 1

1

6

Small-scale

0.479

High

1025138

PKP2
Plakophilin-2

1

1

Small-scale

0.479

High

1025146

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

High-throughput

0.479

High

1025148

MLXPL
Carbohydrate-responsive element-binding protein

1

1

Small-scale

0.479

High

1025154

NXF1
Nuclear RNA export factor 1

1

1

Small-scale

0.479

High

1025157

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.479

High

221561

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.470

High

421931

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.470

High

767968

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

1025110

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.458

High

1025119

MKX
Homeobox protein Mohawk

1

0

Small-scale

0.458

High

1025129

SAP25
Histone deacetylase complex subunit SAP25

1

0

Small-scale

0.458

High

1025155

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

248208

NDK8
Putative nucleoside diphosphate kinase

1

1

High-throughput

0.445

High

330117

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.445

High

871775

RFX3
Transcription factor RFX3

1

1

High-throughput

0.445

High

1025150

DDX28
Probable ATP-dependent RNA helicase DDX28

1

6

High-throughput

0.445

High

293568

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

469280

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

4

Small-scale

0.437

High

1025143

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

158428

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.426

High

529636

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1025113

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1025114

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

169081

ML12B
Myosin regulatory light chain 12B

1

1

Small-scale

0.407

High

391782

PRB2
Basic salivary proline-rich protein 2

1

1

High-throughput

0.407

High

776803

MYH11
Myosin-11

1

1

Small-scale

0.407

High

1025131

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

464908

SP1
Transcription factor Sp1

1

1

Small-scale

0.381

High

675461

TYY1
Transcriptional repressor protein YY1

1

2

Small-scale

0.381

High

378976

PIGR
Polymeric immunoglobulin receptor

3

0

High-throughput

0.347

High

721504

ILEU
Leukocyte elastase inhibitor

3

0

High-throughput

0.347

High

1025135

PAUF
Pancreatic adenocarcinoma up-regulated factor

3

0

High-throughput

0.347

High

378679

IGJ
Immunoglobulin J chain

2

0

High-throughput

0.328

High

517216

AMY1B
Alpha-amylase 1B

2

0

High-throughput

0.288

High

1025137

DEPD7
DEP domain-containing protein 7

1

0

High-throughput

0.282

High

568957

ANXA8
Annexin A8

1

0

High-throughput

0.268

Low

1025104

MLC1
Membrane protein MLC1

1

0

High-throughput

0.268

Low

1025111

FA98C
Protein FAM98C

1

0

High-throughput

0.268

Low

1025120

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

1025144

CN093
Uncharacterized protein C14orf93

1

0

High-throughput

0.268

Low

378370

IFNB
Interferon beta

1

0

Small-scale

0.249

Low

1025108

B2LA1
Bcl-2-related protein A1

1

0

Small-scale

0.249

Low

379091

IGKC
Immunoglobulin kappa constant

1

0

High-throughput

0.232

Low

467007

DAF
Complement decay-accelerating factor

1

0

High-throughput

0.232

Low

619743

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low

1025128

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025