Protein: MED14
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)

Gene: MED14
Organism: Homo sapiens
Interactions: 144
UniProt ID: O60244

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

239549

CDK8
Cyclin-dependent kinase 8

16

17

Small-scale

0.986

High

48879

MED19
Mediator of RNA polymerase II transcription subunit 19

8

2

Small-scale

0.970

High

239614

CDK19
Cyclin-dependent kinase 19

7

17

High-throughput

0.966

High

239612

MED10
Mediator of RNA polymerase II transcription subunit 10

7

4

Small-scale

0.962

High

219460

MED7
Mediator of RNA polymerase II transcription subunit 7

6

5

Small-scale

0.950

High

239571

MED21
Mediator of RNA polymerase II transcription subunit 21

6

2

Small-scale

0.947

High

239620

MED4
Mediator of RNA polymerase II transcription subunit 4

5

2

High-throughput

0.927

High

239616

MED28
Mediator of RNA polymerase II transcription subunit 28

5

1

High-throughput

0.922

High

239621

MED17
Mediator of RNA polymerase II transcription subunit 17

5

3

Small-scale

0.919

High

239636

MED31
Mediator of RNA polymerase II transcription subunit 31

2

4

High-throughput

0.811

High

239580

MED1
Mediator of RNA polymerase II transcription subunit 1

8

14

Small-scale

0.751

High

239602

MED12
Mediator of RNA polymerase II transcription subunit 12

7

19

Small-scale

0.746

High

239538

CCNC
Cyclin-C

6

12

High-throughput

0.729

High

239613

MED18
Mediator of RNA polymerase II transcription subunit 18

5

2

High-throughput

0.722

High

239633

MED23
Mediator of RNA polymerase II transcription subunit 23

5

3

Small-scale

0.720

High

239514

MED26
Mediator of RNA polymerase II transcription subunit 26

5

2

Small-scale

0.718

High

239509

MED24
Mediator of RNA polymerase II transcription subunit 24

5

1

Small-scale

0.714

High

239622

MED9
Mediator of RNA polymerase II transcription subunit 9

5

1

Small-scale

0.712

High

239619

MED20
Mediator of RNA polymerase II transcription subunit 20

4

3

High-throughput

0.699

High

239624

MED29
Mediator of RNA polymerase II transcription subunit 29

4

2

High-throughput

0.699

High

239519

ESR1
Estrogen receptor

4

20

Small-scale

0.692

High

239552

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.691

High

239608

MED15
Mediator of RNA polymerase II transcription subunit 15

4

20

Small-scale

0.686

High

239592

MED25
Mediator of RNA polymerase II transcription subunit 25

4

5

Small-scale

0.683

High

239508

BRD4
Bromodomain-containing protein 4

4

15

Small-scale

0.676

High

239532

VDR
Vitamin D3 receptor

3

20

Small-scale

0.667

High

239560

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

5

High-throughput

0.667

High

239576

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

20

High-throughput

0.667

High

239579

MED22
Mediator of RNA polymerase II transcription subunit 22

3

1

High-throughput

0.667

High

239591

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

4

High-throughput

0.667

High

239631

MED13
Mediator of RNA polymerase II transcription subunit 13

3

4

High-throughput

0.662

High

239587

MED27
Mediator of RNA polymerase II transcription subunit 27

3

2

Small-scale

0.656

High

239635

MED16
Mediator of RNA polymerase II transcription subunit 16

3

1

Small-scale

0.656

High

239511

MED6
Mediator of RNA polymerase II transcription subunit 6

3

5

Small-scale

0.650

High

239554

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

3

High-throughput

0.650

High

239545

SRBP1
Sterol regulatory element-binding protein 1

3

16

Small-scale

0.641

High

239600

ESR2
Estrogen receptor beta

3

20

Small-scale

0.641

High

188624

BIRC5
Baculoviral IAP repeat-containing protein 5

2

3

High-throughput

0.628

High

192761

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

4

High-throughput

0.628

High

239537

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

5

High-throughput

0.628

High

239540

RBTN2
Rhombotin-2

2

7

High-throughput

0.628

High

239606

MED30
Mediator of RNA polymerase II transcription subunit 30

2

2

High-throughput

0.628

High

239638

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

2

3

Small-scale

0.619

High

239557

PLK1
Serine/threonine-protein kinase PLK1

1

7

High-throughput

0.618

High

239536

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

6

High-throughput

0.611

High

239539

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

7

High-throughput

0.611

High

239541

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

9

High-throughput

0.611

High

239558

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

3

High-throughput

0.611

High

239595

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

20

High-throughput

0.611

High

239605

MED8
Mediator of RNA polymerase II transcription subunit 8

2

2

High-throughput

0.611

High

239626

MED11
Mediator of RNA polymerase II transcription subunit 11

2

2

High-throughput

0.611

High

239547

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.595

High

239603

FBXW7
F-box/WD repeat-containing protein 7

2

13

Small-scale

0.584

High

239555

STAT2
Signal transducer and activator of transcription 2

1

6

Small-scale

0.578

High

239520

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.575

High

239527

PARP1
Poly [ADP-ribose] polymerase 1

1

15

Small-scale

0.561

High

239628

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.561

High

130314

SPT5H
Transcription elongation factor SPT5

1

9

High-throughput

0.536

High

138597

IMA4
Importin subunit alpha-4

1

3

High-throughput

0.536

High

239534

GATA1
Erythroid transcription factor

1

5

Small-scale

0.536

High

239556

KIF11
Kinesin-like protein KIF11

1

4

High-throughput

0.536

High

239565

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.536

High

239578

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

239582

HIF1A
Hypoxia-inducible factor 1-alpha

1

14

Small-scale

0.536

High

239586

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

8

High-throughput

0.536

High

239588

FXL19
F-box/LRR-repeat protein 19

1

7

High-throughput

0.536

High

239594

TAD2B
Transcriptional adapter 2-beta

1

5

High-throughput

0.536

High

239604

REPS1
RalBP1-associated Eps domain-containing protein 1

1

3

High-throughput

0.536

High

239634

HECD1
E3 ubiquitin-protein ligase HECTD1

2

18

High-throughput

0.533

High

239521

GCR
Glucocorticoid receptor

1

20

Small-scale

0.527

High

76418

B4DUB1
cyclin-dependent kinase

1

16

High-throughput

0.514

High

239572

LAMB3
Laminin subunit beta-3

1

1

High-throughput

0.489

High

239577

EMC2
ER membrane protein complex subunit 2

1

9

High-throughput

0.489

High

239599

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

239632

GPN3
GPN-loop GTPase 3

1

2

High-throughput

0.489

High

239533

ACTN1
Alpha-actinin-1

1

1

High-throughput

0.481

High

239543

ACTN2
Alpha-actinin-2

1

1

High-throughput

0.481

High

239574

DCTN1
Dynactin subunit 1

1

3

High-throughput

0.481

High

239615

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

5

High-throughput

0.481

High

63913

CNOT1
CCR4-NOT transcription complex subunit 1

1

2

Small-scale

0.479

High

128646

MEN1
Menin

1

8

High-throughput

0.479

High

142737

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

239510

TAD2A
Transcriptional adapter 2-alpha

1

10

High-throughput

0.479

High

239512

UBR5
E3 ubiquitin-protein ligase UBR5

1

19

High-throughput

0.479

High

239513

SCAF4
SR-related and CTD-associated factor 4

1

16

High-throughput

0.479

High

239515

HERC2
E3 ubiquitin-protein ligase HERC2

1

15

High-throughput

0.479

High

239517

ABL1
Tyrosine-protein kinase ABL1

1

15

High-throughput

0.479

High

239523

ISG15
Ubiquitin-like protein ISG15

1

5

Small-scale

0.479

High

239524

FYN
Tyrosine-protein kinase Fyn

1

14

High-throughput

0.479

High

239525

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

239530

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

239535

NCK1
SH2/SH3 adapter protein NCK1

1

18

High-throughput

0.479

High

239542

KINH
Kinesin-1 heavy chain

1

4

High-throughput

0.479

High

239544

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

6

High-throughput

0.479

High

239546

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

239548

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

239551

MECP2
Methyl-CpG-binding protein 2

1

13

High-throughput

0.479

High

239553

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

4

High-throughput

0.479

High

239559

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

4

High-throughput

0.479

High

239561

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

3

High-throughput

0.479

High

239562

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

239563

H31
Histone H3.1

1

20

High-throughput

0.479

High

239564

H33
Histone H3.3

1

20

High-throughput

0.479

High

239566

HSF1
Heat shock factor protein 1

1

5

High-throughput

0.479

High

239567

IRF8
Interferon regulatory factor 8

1

9

Small-scale

0.479

High

239568

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

239569

TP53B
TP53-binding protein 1

1

9

High-throughput

0.479

High

239570

TIF1B
Transcription intermediary factor 1-beta

1

17

High-throughput

0.479

High

239573

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

8

Small-scale

0.479

High

239575

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

239581

SMAD1
Mothers against decapentaplegic homolog 1

1

6

Small-scale

0.479

High

239583

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

11

High-throughput

0.479

High

239584

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

12

High-throughput

0.479

High

239596

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

239597

SIR6
NAD-dependent protein deacylase sirtuin-6

1

10

High-throughput

0.479

High

239598

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

19

Small-scale

0.479

High

239607

QKI
KH domain-containing RNA-binding protein QKI

1

4

High-throughput

0.479

High

239610

T22D3
TSC22 domain family protein 3

1

1

Small-scale

0.479

High

239611

EPAS1
Endothelial PAS domain-containing protein 1

1

14

Small-scale

0.479

High

239618

STN1
CST complex subunit STN1

1

1

High-throughput

0.479

High

239625

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

239629

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

10

Small-scale

0.479

High

239630

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.460

High

239590

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

95740

E5RFK5
Cyclin-C

1

12

High-throughput

0.445

High

239507

LPXN
Leupaxin

1

6

High-throughput

0.445

High

239531

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.445

High

239601

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.445

High

239609

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

239637

TRRAP
Transformation/transcription domain-associated protein

1

4

Small-scale

0.445

High

239518

APOA2
Apolipoprotein A-II

1

1

High-throughput

0.437

High

239522

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.437

High

239526

IBP1
Insulin-like growth factor-binding protein 1

1

1

Small-scale

0.437

High

239528

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

9

Small-scale

0.437

High

239585

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

1

High-throughput

0.437

High

239589

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.437

High

239617

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.437

High

239627

HECW2
E3 ubiquitin-protein ligase HECW2

1

16

High-throughput

0.437

High

239550

CEBPA
CCAAT/enhancer-binding protein alpha

1

17

High-throughput

0.408

High

239529

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

2

High-throughput

0.407

High

239516

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

239593

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.251

Low

239623

ASND1
Asparagine synthetase domain-containing protein 1

1

0

High-throughput

0.249

Low

117723

ASURF
ASNSD1 upstream open reading frame protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025