HitPredict

Interactor 1: MDM2 (P23804)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: UBC9 (P63280)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (mUBC9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)
Gene: Ube2i

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21183956
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0016604 - nuclear body
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 489 Mm			1 158
+	Mm
		620834 MDM2_MOUSE (1-489): 0: 673: 100.00		UB2D1_MOUSE (4-157): 7.96e-75: 221: 33.12
+	Mm
		620833 MDM2_MOUSE (1-489): 0: 673: 100.00		UB2D3_MOUSE (4-157): 6.67e-73: 216: 35.07
+	Hs
		963034 MDM2_HUMAN (1-488): 0: 636: 80.85		UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42
+	Hs
		849309 MDM2_HUMAN (1-488): 0: 636: 80.85		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		919708 MDM2_HUMAN (1-488): 0: 636: 80.85		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Hs
		895778 MDM2_HUMAN (1-488): 0: 636: 80.85		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		930146 MDM2_HUMAN (1-488): 0: 636: 80.85		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		962924 MDM2_HUMAN (1-488): 0: 636: 80.85		UB2E2_HUMAN (3-156): 7.29e-69: 208: 33.77
+	Hs
		962909 MDM2_HUMAN (1-488): 0: 636: 80.85		UB2E3_HUMAN (3-156): 2.14e-68: 207: 33.77
+	Hs
		851803 MDM2_HUMAN (1-488): 0: 636: 80.85		UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12
+	Hs
		828987 MDM2_HUMAN (1-488): 0: 636: 80.85		UBE2A_HUMAN (1-154): 3.37e-67: 202: 41.56
+	Hs
		927746 MDM2_HUMAN (1-488): 0: 636: 80.85		UBE2B_HUMAN (1-154): 1.37e-66: 201: 41.56
+	Hs
		169259 MDM4_HUMAN (4-488): 0: 560: 31.61		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		169270 MDM4_HUMAN (4-488): 0: 560: 31.61		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Hs
		169262 MDM4_HUMAN (4-488): 0: 560: 31.61		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07