HitPredict - High confidence protein-protein interactions

Interactor 1: EMRE (P23895)
Multidrug transporter EmrE (Efflux-multidrug resistance protein EmrE) (Ethidium resistance protein) (Methyl viologen resistance protein C)
Gene: EMRE

Interactor 2: EMRE (P23895)
Multidrug transporter EmrE (Efflux-multidrug resistance protein EmrE) (Ethidium resistance protein) (Methyl viologen resistance protein C)
Gene: EMRE

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.90	0.738

Property	Details
Experiments	18024586, 20541505
Identification Methods	x-ray crystallography, blue native page
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Multi_Drug_Res~Multi_Drug_Res
Common GO terms	GO:0005886 - plasma membrane GO:0006805 - xenobiotic metabolic process GO:0006970 - response to osmotic stress GO:0006974 - DNA damage response GO:0009410 - response to xenobiotic stimulus and 13 others more... GO:0015199 - amino-acid betaine transmembrane transporter activity GO:0015220 - choline transmembrane transporter activity GO:0015297 - antiporter activity GO:0015871 - choline transport GO:0016020 - membrane GO:0022857 - transmembrane transporter activity GO:0031460 - glycine betaine transport GO:0042908 - xenobiotic transport GO:0042910 - xenobiotic transmembrane transporter activity GO:0055085 - transmembrane transport GO:0071466 - cellular response to xenobiotic stimulus GO:1990207 - EmrE multidrug transporter complex GO:1990961 - xenobiotic detoxification by transmembrane export across the plasma membrane
Homologous interactions	0

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Last updated: 15 Jul 2024