HitPredict

Interactor 1: CCND1 (P24385)
G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Gene: CCND1

Interactor 2: CDN1C (P49918)
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
Gene: CDKN1C

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	10713702, 10764802, 28514442, 33961781, 34591642
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CDI~Cyclin_N
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 295 Hs			1 316
+	Hs
		538496 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		303838 CCNB2_HUMAN (7-287): 1.34e-85: 263: 18.09		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		758186 CCNA1_HUMAN (7-281): 7.64e-89: 274: 23.91		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		538489 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Mm
		624384 CCNB1_MOUSE (5-286): 9.4e-87: 267: 20.50		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Mm
		763418 CCNA1_MOUSE (15-281): 6.39e-86: 265: 24.63		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Hs
		303835 CCNB2_HUMAN (7-287): 1.34e-85: 263: 18.09		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Mm
		673120 CCND2_MOUSE (3-295): 1.23e-83: 254: 62.80		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Hs
		804103 CCNA1_HUMAN (7-281): 7.64e-89: 274: 23.91		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		538492 CCNB1_HUMAN (5-282): 3.94e-89: 273: 20.64		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Mm
		629204 CCND1_MOUSE (1-295): 1.76e-82: 252: 93.90		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Mm
		673180 CCND3_MOUSE (4-295): 5.1e-86: 261: 50.51		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Hs
		590139 CCNA2_HUMAN (3-286): 6.9e-81: 252: 24.48		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Mm
		673121 CCND2_MOUSE (3-295): 1.23e-83: 254: 62.80		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Hs
		303836 CCNB2_HUMAN (7-287): 1.34e-85: 263: 18.09		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Mm
		629206 CCND1_MOUSE (1-295): 1.76e-82: 252: 93.90		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Mm
		803837 CCNA2_MOUSE (1-286): 3.39e-81: 252: 25.35		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Hs
		590142 CCNA2_HUMAN (3-286): 6.9e-81: 252: 24.48		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Xl
		1146034 Q66J45_XENLA (2-281): 2.63e-82: 256: 24.56		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Xl
		1151481 Q6GME9_XENLA (7-286): 4.02e-82: 255: 25.18		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46