Protein: LEUC
3-isopropylmalate dehydratase (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase)

Gene: LEUC, LEU1
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: P07264

Gene Ontology (top 5):
GO:0003861 - 3-isopropylmalate dehydratase activity
GO:0005829 - cytosol
GO:0009098 - L-leucine biosynthetic process
GO:0009316 - 3-isopropylmalate dehydratase complex
GO:0010494 - cytoplasmic stress granule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

454225

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

1

High-throughput

0.640

High

392018

HSP82
ATP-dependent molecular chaperone HSP82

3

5

High-throughput

0.633

High

454192

HSC82
ATP-dependent molecular chaperone HSC82

3

5

High-throughput

0.633

High

454199

SIS1
Protein SIS1

2

3

High-throughput

0.584

High

454189

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

454218

SSB2
Ribosome-associated molecular chaperone SSB2

2

11

High-throughput

0.552

High

358085

ADH1
Alcohol dehydrogenase 1

2

2

High-throughput

0.537

High

454229

ULP1
Ubiquitin-like-specific protease 1

2

2

High-throughput

0.535

High

454223

ERG10
Acetyl-CoA acetyltransferase

1

1

High-throughput

0.515

High

454228

YG5B
Uncharacterized RNA-binding protein YGR250C

1

3

High-throughput

0.515

High

454213

YHS2
MIP18 family protein YHR122W

1

2

Small-scale

0.501

High

454210

ANM1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.494

High

364235

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

439189

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.479

High

454195

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

1

High-throughput

0.479

High

454200

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

454216

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

454217

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

454237

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

454197

SYMM
Methionine--tRNA ligase, mitochondrial

1

1

High-throughput

0.470

High

454224

ETFB
Probable electron transfer flavoprotein subunit beta

1

2

High-throughput

0.470

High

454187

PBS2
MAP kinase kinase PBS2

1

0

High-throughput

0.458

High

454211

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

454219

MET18
DNA repair/transcription protein MET18/MMS19

1

0

Small-scale

0.458

High

454248

TFB5
General transcription and DNA repair factor IIH subunit TFB5

1

0

Small-scale

0.458

High

454188

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.445

High

454190

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

454203

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

454215

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

454241

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.445

High

454191

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

454201

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

454206

IXR1
Intrastrand cross-link recognition protein

1

1

Small-scale

0.437

High

454208

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

454209

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.437

High

454214

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

1

Small-scale

0.437

High

454220

ULP2
Ubiquitin-like-specific protease 2

1

2

Small-scale

0.437

High

454222

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

454230

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

454235

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.437

High

454238

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

High-throughput

0.437

High

454239

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

454240

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

3

Small-scale

0.437

High

454243

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

454244

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

High-throughput

0.437

High

454245

SMT3
Ubiquitin-like protein SMT3

1

3

High-throughput

0.437

High

454246

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

454247

RUVB2
RuvB-like protein 2

1

4

High-throughput

0.437

High

454205

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.407

High

454202

HOG1
Mitogen-activated protein kinase HOG1

2

0

High-throughput

0.305

High

454232

TDA1
Serine/threonine-protein kinase TDA1

1

0

High-throughput

0.279

Low

454198

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.269

Low

454193

SPO16
Sporulation-specific protein 16

1

0

Small-scale

0.249

Low

454194

PGTB1
Geranylgeranyl transferase type-1 subunit beta

1

0

High-throughput

0.249

Low

454196

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

454204

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.249

Low

454207

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

454212

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

454221

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

454226

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

454227

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

454231

VPS60
Vacuolar protein-sorting-associated protein 60

1

0

Small-scale

0.249

Low

454233

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

454234

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

454236

RAV2
Regulator of V-ATPase in vacuolar membrane protein 2

1

0

Small-scale

0.249

Low

454242

SGO1
Shugoshin

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025