HitPredict

Interactor 1: RAE1 (P24386)
Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein)
Gene: CHM

Interactor 2: RAB7A (P51149)
Ras-related protein Rab-7a (EC 3.6.5.2)
Gene: RAB7A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	12576024, 9563513, 35271311, 34432599
Identification Methods	x-ray crystallography, pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	GO:0005829 - cytosol GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 653 Hs			1 207
+	Hs
		622577 RAE1_HUMAN (1-653): 0: 996: 100.00		RAB1A_HUMAN (1-206): 7.27e-87: 256: 33.50
+	Hs
		622619 RAE1_HUMAN (1-653): 0: 996: 100.00		RAB1B_HUMAN (1-205): 2.14e-86: 255: 34.15
+	Hs
		622608 RAE1_HUMAN (1-653): 0: 996: 100.00		RAB8B_HUMAN (1-206): 1.29e-79: 238: 33.97
+	Hs
		622576 RAE1_HUMAN (1-653): 0: 996: 100.00		RB11A_HUMAN (2-205): 1.09e-78: 236: 30.99
+	Hs
		622570 RAE1_HUMAN (1-653): 0: 996: 100.00		RAB8A_HUMAN (1-205): 1.09e-78: 235: 31.73
+	Hs
		622621 RAE1_HUMAN (1-653): 0: 996: 100.00		RAB9B_HUMAN (3-181): 1.97e-69: 212: 55.87
+	Hs
		622567 RAE1_HUMAN (1-653): 0: 996: 100.00		RAB9A_HUMAN (5-177): 3.51e-68: 209: 56.65
+	Hs
		642723 RAE2_HUMAN (1-650): 0: 938: 71.98		RAB1A_HUMAN (1-206): 7.27e-87: 256: 33.50
+	Rn
		451805 RAE1_RAT (1-653): 0: 948: 82.93		RAB7A_RAT (1-207): 8.79e-80: 238: 99.52
+	Hs
		622610 RAE1_HUMAN (1-653): 0: 996: 100.00		RAB7B_HUMAN (1-192): 8.65e-61: 190: 50.00
+	Hs
		642711 RAE2_HUMAN (1-650): 0: 938: 71.98		RAB7A_HUMAN (1-207): 5.09e-80: 239: 100.00
+	Hs
		642738 RAE2_HUMAN (1-650): 0: 938: 71.98		RAB8B_HUMAN (1-206): 1.29e-79: 238: 33.97
+	Hs
		642722 RAE2_HUMAN (1-650): 0: 938: 71.98		RB11A_HUMAN (2-205): 1.09e-78: 236: 30.99
+	Hs
		642718 RAE2_HUMAN (1-650): 0: 938: 71.98		RAB8A_HUMAN (1-205): 1.09e-78: 235: 31.73
+	Hs
		642712 RAE2_HUMAN (1-650): 0: 938: 71.98		RAB9A_HUMAN (5-177): 3.51e-68: 209: 56.65
+	Hs
		622581 RAE1_HUMAN (1-653): 0: 996: 100.00		RAB31_HUMAN (9-171): 2.21e-38: 132: 44.51
+	Hs
		642740 RAE2_HUMAN (1-650): 0: 938: 71.98		RAB7B_HUMAN (1-192): 8.65e-61: 190: 50.00
+	Hs
		622565 RAE1_HUMAN (1-653): 0: 996: 100.00		RAB5C_HUMAN (9-179): 1.56e-37: 131: 42.44
+	Hs
		642725 RAE2_HUMAN (1-650): 0: 938: 71.98		RAB31_HUMAN (9-171): 2.21e-38: 132: 44.51
+	Hs
		642710 RAE2_HUMAN (1-650): 0: 938: 71.98		RAB5C_HUMAN (9-179): 1.56e-37: 131: 42.44