HitPredict

Interactor 1: KPCL (P24723)
Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta)
Gene: PRKCH

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030154 - cell differentiation and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 683 Hs			1 196
+	Rn
		448411 KPCD_RAT (34-682): 0: 689: 42.84		RAC1_RAT (1-196): 2.37e-79: 236: 55.10
+	Hs
		900406 KPCD_HUMAN (34-682): 0: 690: 42.71		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915625 KPCD_HUMAN (34-682): 0: 690: 42.71		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		436269 KPCD_HUMAN (34-682): 0: 690: 42.71		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		925308 PKN2_HUMAN (3-678): 1.1e-180: 541: 29.54		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		900514 PKN2_HUMAN (3-678): 1.1e-180: 541: 29.54		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915706 PKN2_HUMAN (3-678): 1.1e-180: 541: 29.54		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		545401 PKN2_HUMAN (3-678): 1.1e-180: 541: 29.54		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436326 PKN2_HUMAN (3-678): 1.1e-180: 541: 29.54		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		951021 PKN2_HUMAN (3-678): 1.1e-180: 541: 29.54		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		894056 PKN2_HUMAN (3-678): 1.1e-180: 541: 29.54		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		925307 PKN1_HUMAN (4-678): 1.66e-169: 511: 27.39		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		120458 PKN2_HUMAN (3-678): 1.1e-180: 541: 29.54		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		900513 PKN1_HUMAN (4-678): 1.66e-169: 511: 27.39		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915705 PKN1_HUMAN (4-678): 1.66e-169: 511: 27.39		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Ce
		107919 G5EFX2_CAEEL (5-678): 1.2e-162: 495: 26.17		RAC1_CAEEL (1-196): 5.29e-80: 238: 53.57
+	Hs
		900594 PKN3_HUMAN (4-683): 1.69e-163: 494: 25.67		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		915766 PKN3_HUMAN (4-683): 1.69e-163: 494: 25.67		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Ce
		104463 G5EFX2_CAEEL (5-678): 1.2e-162: 495: 26.17		G5EBV3_CAEEL (2-196): 7.03e-76: 227: 48.72
+	Ce
		107920 G5EFX2_CAEEL (5-678): 1.2e-162: 495: 26.17		RHO1_CAEEL (1-196): 4.36e-75: 225: 78.57