HitPredict

Interactor 1: CCNC (P24863)
Cyclin-C (SRB11 homolog) (hSRB11)
Gene: CCNC

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	26186194, 28514442, 33961781, 24981860, 20133760, 30099503
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1990508 - CKM complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 283 Hs			1 2177
+	Mm
		57103 CCNC_MOUSE (1-283): 9.53e-80: 244: 99.29		MED12_MOUSE (1-2049): 0: 2476: 97.13
+	Hs
		91304 E5RFK5_HUMAN (1-257): 8.34e-74: 229: 100.00		MED12_HUMAN (1-2177): 0: 2488: 100.00
+	Hs
		624463 CCNC_HUMAN (1-283): 1.05e-79: 244: 100.00		MD12L_HUMAN (1-2175): 0: 2159: 56.63
+	Hs
		91302 E5RFK5_HUMAN (1-257): 8.34e-74: 229: 100.00		MD12L_HUMAN (1-2175): 0: 2159: 56.63
+	Dm
		625730 CCNC_DROME (1-256): 2e-75: 232: 71.60		MED12_DROME (10-206): 7.4e-71: 267: 52.53
+	Hs
		590210 CCNA2_HUMAN (2-268): 3.32e-71: 227: 15.07		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45