HitPredict

Interactor 1: CDK1 (P00546)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (Cell division control protein 28) (Cell division protein kinase 1)
Gene: CDC28

Interactor 2: PCL7 (P40186)
PHO85 cyclin-7 (PHO85-associated protein 1)
Gene: PCL7

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	14574415, 10688190, 17634282, 14690591
Identification Methods	protein kinase assay, two hybrid, enzymatic study, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cyclin~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Sc			1 285
+	Sc
		565624 PHO85_YEAST (6-297): 2.21e-126: 364: 52.67		PCL7_YEAST (1-285): 4.69e-117: 339: 100.00
+	Sc
		339662 CDK1_YEAST (1-298): 1.93e-142: 404: 100.00		PCL6_YEAST (50-284): 8.48e-65: 210: 43.43
+	At
		621726 CDKA1_ARATH (5-297): 3.44e-139: 396: 61.22		CCU21_ARATH (89-280): 1.18e-61: 196: 27.60
+	At
		621696 CDKA1_ARATH (5-297): 3.44e-139: 396: 61.22		CCU43_ARATH (84-280): 1.6e-61: 195: 28.43
+	At
		621719 CDKA1_ARATH (5-297): 3.44e-139: 396: 61.22		CCU22_ARATH (89-280): 1.33e-59: 191: 28.65
+	At
		621714 CDKA1_ARATH (5-297): 3.44e-139: 396: 61.22		CCU42_ARATH (101-280): 1.49e-58: 188: 30.56
+	At
		285423 CDKA1_ARATH (5-297): 3.44e-139: 396: 61.22		CCU41_ARATH (107-280): 1.64e-58: 187: 36.21
+	At
		621706 CDKA1_ARATH (5-297): 3.44e-139: 396: 61.22		CCU11_ARATH (89-280): 1.55e-55: 180: 29.17
+	Sc
		565612 PHO85_YEAST (6-297): 2.21e-126: 364: 52.67		PCL6_YEAST (50-284): 8.48e-65: 210: 43.43
+	Sc
		565812 PHO85_YEAST (6-297): 2.21e-126: 364: 52.67		PCL8_YEAST (30-273): 1.75e-61: 203: 22.18
+	At
		621675 CDKA1_ARATH (5-297): 3.44e-139: 396: 61.22		CCU31_ARATH (144-280): 1.95e-51: 170: 31.39
+	At
		1227956 CKB21_ARATH (3-297): 6.02e-127: 365: 51.33		CCU11_ARATH (89-280): 1.55e-55: 180: 29.17
+	At
		1228089 CKB22_ARATH (3-297): 7.97e-126: 363: 52.32		CCU11_ARATH (89-280): 1.55e-55: 180: 29.17
+	Sc
		565703 PHO85_YEAST (6-297): 2.21e-126: 364: 52.67		PCL10_YEAST (57-281): 1.81e-49: 170: 22.17
+	Sp
		195004 PEF1_SCHPO (7-295): 2.56e-121: 350: 52.60		PSL1_SCHPO (86-282): 6.93e-55: 179: 42.42
+	At
		639348 CKB11_ARATH (5-296): 5.62e-122: 353: 55.23		CCU31_ARATH (144-280): 1.95e-51: 170: 31.39
+	Hs
		960443 CDK17_HUMAN (3-296): 5.24e-97: 296: 51.53		CCYL1_HUMAN (30-284): 2.06e-69: 220: 18.28
+	Hs
		960388 CDK16_HUMAN (3-295): 5.98e-96: 293: 51.36		CCYL1_HUMAN (30-284): 2.06e-69: 220: 18.28
+	Hs
		960390 CDK16_HUMAN (3-295): 5.98e-96: 293: 51.36		CCNY_HUMAN (36-283): 5.57e-67: 213: 17.11
+	Sc
		565447 PHO85_YEAST (6-297): 2.21e-126: 364: 52.67		PHO80_YEAST (92-264): 8.38e-35: 128: 27.27