HitPredict

Interactor 1: HELT (A6NFD8)
Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor)
Gene: HELT

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	32296183
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 197
+	Hs
		980671 HEY1_HUMAN (1-236): 3.93e-59: 190: 30.80		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980604 HES1_HUMAN (7-239): 3.37e-53: 174: 22.54		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		421 A0A087WSW0_HUMAN (6-242): 8.24e-69: 216: 83.81		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		980948 HES6_HUMAN (2-211): 3.54e-48: 160: 23.72		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		980638 HES6_HUMAN (2-211): 3.54e-48: 160: 23.72		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980840 HES6_HUMAN (2-211): 3.54e-48: 160: 23.72		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Mm
		1143960 HES6_MOUSE (2-211): 1.24e-48: 161: 25.12		TLE1_MOUSE (2-197): 2.15e-101: 310: 63.00
+	Hs
		980651 HES4_HUMAN (6-198): 1.17e-36: 130: 24.87		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		993550 HES6_HUMAN (2-211): 3.54e-48: 160: 23.72		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		146485 BHE40_HUMAN (2-193): 6.85e-38: 138: 21.64		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		980686 HES1_HUMAN (7-239): 3.37e-53: 174: 22.54		TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62
+	Dm
		558377 DPN_DROME (11-240): 3.54e-50: 171: 21.62		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558369 ESM3_DROME (3-211): 5.99e-51: 167: 19.09		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		525718 ESM7_DROME (3-178): 2.37e-48: 159: 22.11		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		525743 ESM8_DROME (1-178): 3.53e-47: 156: 19.13		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558371 ESMC_DROME (1-142): 1.12e-45: 153: 24.31		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558370 ESMB_DROME (3-178): 3.69e-45: 151: 21.35		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558372 ESMD_DROME (4-178): 1.7e-44: 148: 21.35		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		525705 ESM5_DROME (5-178): 2.71e-43: 146: 16.67		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		534341 HAIR_DROME (8-200): 8.13e-36: 131: 23.50		GROU_DROME (2-163): 3.54e-59: 198: 54.44