HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	16446360, 21319273
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0006260 - DNA replication
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 904
+	Hs
		414822 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		625167 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		414780 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Sc
		565489 PHO85_YEAST (3-290): 6.29e-131: 375: 54.88		MCM2_YEAST (11-821): 0: 819: 46.70
+	Hs
		625116 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MCM3_HUMAN (186-897): 0: 725: 29.20
+	Hs
		625435 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Hs
		625168 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		MCM7_HUMAN (188-886): 0: 707: 27.35
+	Sc
		565493 PHO85_YEAST (3-290): 6.29e-131: 375: 54.88		MCM4_YEAST (7-889): 0: 764: 25.82
+	Sc
		565490 PHO85_YEAST (3-290): 6.29e-131: 375: 54.88		MCM5_YEAST (170-875): 0: 723: 28.23
+	Hs
		627215 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		MCM3_HUMAN (186-897): 0: 725: 29.20
+	Hs
		708843 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		MCM7_HUMAN (188-886): 0: 707: 27.35